银杏叶黄酮化合物提取和纯化研究进展
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摘要
系统归纳总结了银杏叶黄酮化合物提取和纯化方法,从提取率、提取纯度、工业化适用性和环保性等角度,详细分析了溶剂提取法、酶辅助提取法、微波提取法、超声波提取法和超临界CO_2萃取提取法的优缺点;并根据银杏叶黄酮化合物的结构差异性,对其纯化方法-膜分离、大孔树脂和聚酰胺分离等研究现状系统地总结对比;最后,对银杏叶黄酮化合物的提取开发技术提出建议和展望。
Extraction and purification methods of flavonoids from Ginkgo biloba leaves were introduced, including organic solvent method, enzyme-assisted method, microwave-assisted method, ultrasonic method, supercritical CO_2 extraction method and so on. Their advantages and disadvantages were discussed from the aspects of extraction yield,extraction purity, industrial applicability and environmental protection effect. Furthermore, the research progress of membrane separation, microporous resin and polyamide resin purification methods were systematically reviewed. In the end, the development trend of extraction and purification technologies of Ginkgo biloba leaf flavonoids was prospected.
Extraction and purification methods of flavonoids from Ginkgo biloba leaves were introduced, including organic solvent method, enzyme-assisted method, microwave-assisted method, ultrasonic method, supercritical CO_2 extraction method and so on. Their advantages and disadvantages were discussed from the aspects of extraction yield,extraction purity, industrial applicability and environmental protection effect. Furthermore, the research progress of membrane separation, microporous resin and polyamide resin purification methods were systematically reviewed. In the end, the development trend of extraction and purification technologies of Ginkgo biloba leaf flavonoids was prospected.
引文
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[27]孙胜斌,丁艳谱,冯玉康,等.基于黄酮类特征图谱和总黄酮醇苷含量优化AB-8大孔树脂制备银杏叶提取物工艺[J].中华中医药学刊,2017,5:1134-1138.
[28]王永刚.银杏总酮酯有效部位的制备工艺及质量研究[D].山东大学,2010.
[29]ZHANG Jing,KHIZAR Hayat,ZHANG Xiaoming,et al.Separation and purification of flavonoid from ginkgo extract by polyamide resin[J].Separation Science and Technology,2010,45(16):2413-2419.
[30]李保同,徐永霞,李娟,等.纤维素酶-微波辅助提取银杏叶总黄酮及抗氧化性能研究[J].现代化工,2016(3):67-70.
[31]金华,钟方丽,李秀萍,等.杏叶黄酮活性炭脱色工艺的研究[J].食品研究与开发,2017,38(8):85-88.
[32]张光辉,孟庆华,龙旭,等.响应面法优化超声辅助银杏叶中黄酮的提取及其抗自由基活性研究[J].当代化工,2018(1):17-19.
[33]徐友,王欢利,汪贵斌,等.温度和光照强度对银杏叶黄酮合成的影响[J].中南林业科技大学学报,2016,36(4):30-34.
[34]姚鑫,薛平,郁丹红,等.UPLC-MS/MS测定银杏叶提取物中5种微量银杏酸[J].中国实验方剂学杂志,2017,18:174-179.
[2]陈西娟,王成章,叶建中.银杏叶化学成分及其应用研究进展[J].生物质化学工程,2008,42(4):57-62.
[3]陶锋,李向荣,占洁.黄酮醇类化合物提取分离方法的研究进展[J].中药材,2008,31(10):1586-1589.
[4]闫高颖,张必荣,张敏,等.水浸法提取银杏叶总黄酮工艺的研究[J].西北药学杂志,2016,31(6):560-562.
[5]薛志彬,承伟.银杏叶黄酮提取工艺的优化[J].安徽农业科学,2011,39(10):5751-5752.
[6]贾长英,唐丽华,张晓娟,等.银杏叶黄酮的乙醇提取工艺优化及动力学研究[J].农业机械,2012,12(36):90-90.
[7]王旭,王志,蔡梦宇,等.纤维素酶Umcel9y-1在银杏叶总黄酮提取中的增效作用[J].安徽农业大学学报,2017,44(1):22-26.
[8]PURI M.,SHARMA D.,BARROW C.J.Enzyme-assisted extraction of bioactives from plants[J].Trends in biotechnology,2012,30(1):37-44.
[9]吴梅林,周春山,陈龙胜,等.酶法提取银杏黄酮类化合物研究[J].天然产物研究与开发,2004,16(6):557-560.
[10]CHEN Shuo,XING Xinhui,HUANG Jianjun,et al.Enzyme-assisted extraction of flavonoids from Ginkgo biloba leaves:Improvement effect of flavonol transglycosylation catalyzed by Penicillium decumbens cellulase[J].Enzyme and microbial technology,2011,48(1):100-105.
[11]吴昊,宗志敏,李秀秀.超声-微波协同萃取银杏叶黄酮与内酯B的工艺研究,中国酿造,2016,35(10):153-156.
[12]盛玮,滕井通,薛建平,等.响应面优化超声-微波协同提取黄秋花中总黄酮工艺的研究[J].食品工业科技,2015,36(8):290-293.
[13]徐春明,王英英,李婷,等.银杏叶总黄酮的微波提取及生物利用度研究[J].林产化学与工业,2014,34(4):131-136.
[14]豁银强,尹杰,陈雪.银杏叶黄酮的超声波提取及其抗菌研究[J].食品工业,2012(5):47-49.
[15]GAO Han,LIU Benguo,NAN Haijuan,et al.Optimization of ultrasonic-assisted extraction of flavonoids with ethanol from ginkgo leaves by response surface methodology[C].ITIME'09.IEEEInternational Symposium on.IEEE,2009,1:1154-1157.
[16]房磊.超声波辅助提取银杏叶黄酮及体外抗运动氧化作用研究[J].食品研究与开发,2016,37(17):153-157.
[17]黄莉莉,汪良峰,崔政伟.介尺度下微波和超声波辅助提取银杏黄酮的比较研究[J].食品科技,2017,5:188-193.
[18]何扩.超临界CO2萃取银杏黄酮类物质工艺的研究[D].西华大学,2006.
[19]韩玉谦,隋晓.银杏叶活性成分萃取工艺的研究[J].精细化工,2000,(9):505-506.
[20]刘雯,李素娟,马丹凤.超临界CO2萃取银杏叶中总黄酮醇苷的夹带剂工艺条件[J].中国现代医学杂志,2017,27(3):41-44.
[21]XU Zhihong,LI Lei,Wu Fawen,et al.The application of the modified PVDF ultrafiltration membranes in further purification of Ginkgo biloba extraction[J].Journal of membrane science,2005,255(1):125-131.
[22]ZHU Minghang,YUN Yanbin,XIANG Wenyi.Purification of Ginkgo biloba flavonoids by UF membrane technology[J].Desalination and Water Treatment,2013,51(19-21):3847-3853.
[23]贠延滨.利用膜分离提纯银杏黄酮的方法:中国,102302522A(P).2012-01-04.
[24]吴梅林,周春山,钟世安,等.大孔吸附树脂纯化银杏活性化合物的工艺研究[J].中南药学,2005,3(2):75-77.
[25]吴昊,宗志敏,石金龙.S-8大孔吸附树脂分离纯化银杏黄酮的工艺研究[J].食品科技,2013(4):224-227.
[26]倪力军,颜玮韬,张立国.银杏叶黄酮含量对银杏叶提取物大孔树脂纯化工艺条件的影响研究[J].天然产物研究与开发,2017,12:2097-2103.
[27]孙胜斌,丁艳谱,冯玉康,等.基于黄酮类特征图谱和总黄酮醇苷含量优化AB-8大孔树脂制备银杏叶提取物工艺[J].中华中医药学刊,2017,5:1134-1138.
[28]王永刚.银杏总酮酯有效部位的制备工艺及质量研究[D].山东大学,2010.
[29]ZHANG Jing,KHIZAR Hayat,ZHANG Xiaoming,et al.Separation and purification of flavonoid from ginkgo extract by polyamide resin[J].Separation Science and Technology,2010,45(16):2413-2419.
[30]李保同,徐永霞,李娟,等.纤维素酶-微波辅助提取银杏叶总黄酮及抗氧化性能研究[J].现代化工,2016(3):67-70.
[31]金华,钟方丽,李秀萍,等.杏叶黄酮活性炭脱色工艺的研究[J].食品研究与开发,2017,38(8):85-88.
[32]张光辉,孟庆华,龙旭,等.响应面法优化超声辅助银杏叶中黄酮的提取及其抗自由基活性研究[J].当代化工,2018(1):17-19.
[33]徐友,王欢利,汪贵斌,等.温度和光照强度对银杏叶黄酮合成的影响[J].中南林业科技大学学报,2016,36(4):30-34.
[34]姚鑫,薛平,郁丹红,等.UPLC-MS/MS测定银杏叶提取物中5种微量银杏酸[J].中国实验方剂学杂志,2017,18:174-179.