新型半导体制冷肾脏灌注保存箱的实验研究
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摘要
低温灌注保存箱可保证移植肾在摘离人体后的质量,而目前存在的保存箱内温度不均、设备运行时间短等不足会影响移植肾的保存质量。针对这些不足,通过加装一套小型半导体制冷系统,该保存箱可在两小时内将箱内仿离体肾脏降至4℃,并稳定运行时长达35小时。实验结果表明,新型保存箱提升了使用性能,离体肾脏保存温度得到保障,病人术后生存质量和存活率也得以提高。
The low-temperature perfusion preservation box can guarantee the quality of the kidney off-body,but the current low-temperature perfusion preservation box has the disadvantages of uneven temperature in the box and short operation time of the equipment.To address these deficiencies,installing a small semiconductor refrigeration system,the temperature of simulated kidney off-body could be reduced to 4°C within 2 hours and the box could be operated for as long as 35 hours in this study.The experimental results show that the performance of new storage box is improved,and the temperature of kidney off-body is guaranteed.The patient's postoperative quality of life and survival rate are improved.
The low-temperature perfusion preservation box can guarantee the quality of the kidney off-body,but the current low-temperature perfusion preservation box has the disadvantages of uneven temperature in the box and short operation time of the equipment.To address these deficiencies,installing a small semiconductor refrigeration system,the temperature of simulated kidney off-body could be reduced to 4°C within 2 hours and the box could be operated for as long as 35 hours in this study.The experimental results show that the performance of new storage box is improved,and the temperature of kidney off-body is guaranteed.The patient's postoperative quality of life and survival rate are improved.
引文
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[2]张丽,丰贵文,尚文俊,等.接受逝世器官捐献肾移植与亲属活体肾移植受者围移植期输血的差异[J].中国组织工程研究,2015,19(2):257-261.
[3]HUANG J F,ZHENG S S,LIU Y F,et al.China organ donation and transplantation update:the Hangzhou Resolution.[J].Hepatobiliary&Pancreatic Diseases International,2014,13(2):122-124.
[4]HUANG J F,WANG H B,ZHENG S S,et al.Advances in China's Organ Transplantation Achieved with the Guidance of Law[J].中华医学杂志(英文版),2015,128(2):143-146.
[5]晏强,韦晓莲,李飞,杨明,陈怀周,谢申平,郭骏军,刘平,史锋,眭维国.机械灌注应用在肾移植中的效果评价(附36例报道)[J].器官移植,2014,5(03):182-185.
[6]St PETER S D,IMBER C J,FRIEND P J.Liver and kidney preservation by perfusion[J].Lancet,2002,359(9306):604-613.
[7]董建辉,廖吉祥,孙煦勇,等.Life Port保存心脏死亡器官捐献供肾的临床研究[J].临床泌尿外科杂志,2014(8):697-700.
[8]郑宇薇,刘晓华,涂壤.半导体制冷与固体除湿结合装置的性能探究[J].制冷学报,2013,34(5):59-64.
[9]赵福云,常菁菁,刘娣,等.半导体制冷箱实验研究与性能分析[J].武汉大学学报(工学版),2016,49(3):476-480.
[10]廖吉祥,低温机器灌注对DCD供肾的保存效果的临床研究[D].桂林:桂林医学院,2014.
[11]张欢,谢晋良,陈志.改良手术后腹腔镜活体取肾及自体肾移植治疗严重医源性输尿管缺损(附7例报告并文献复习)[J].中国医学工程,2017(3):55-57.