树突状细胞与化学品过敏原筛选的研究进展
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摘要
皮肤致敏性检测(皮肤变态反应试验)是一项非常重要的化学品、新材料、新产品安全检测的指标之一,鉴于过敏性反应的危害严重性而备受重视。随着人们对动物福利的关注,各种替代方法的研究方兴未艾。其重点是探讨该过程中主要的关键作用机理和基因调控机制,方可为建立新型的体外过敏测试方法提供直接的科学依据。体外方法从in chemico(DPRA)到in silico(QSAR相关方法)、RHE(体外重组表皮),都取得了一定的进展。树突状细胞(DCs)在变态反应的调控中起到重要的启动和抗原呈递作用而得到日益关注。
Skin sensitization tests are pivotal assessments of safety for final industry products or the related raw materials. The animal studies were most frequently used and believed methods for this purpose as usual, but with extremely considering and pressures of animal's welfares. There are many kinds of replacements for animals' studies. For the skin sensitization test are deep and considerable directions for these concerns. The authorized methods include DPRA as in chemico, QSAR as in silico, RHE(reconstructed human epidermis) models as in vitro. At the same time, DCs are key APC cells for immunological initiation and antigen presenting, so its related methods are booming now.
Skin sensitization tests are pivotal assessments of safety for final industry products or the related raw materials. The animal studies were most frequently used and believed methods for this purpose as usual, but with extremely considering and pressures of animal's welfares. There are many kinds of replacements for animals' studies. For the skin sensitization test are deep and considerable directions for these concerns. The authorized methods include DPRA as in chemico, QSAR as in silico, RHE(reconstructed human epidermis) models as in vitro. At the same time, DCs are key APC cells for immunological initiation and antigen presenting, so its related methods are booming now.
引文
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[25]Kowalewski C,Kurpios-Pieca D,Rahden-Staron I,et al.The potential role of NK-k B activation and synthesis of pro-inflammatory mediators in the pathogenesis of allergic contact dermatitis induced by thiuram[J].Clin Translational Allergy,2015,5.
[2]Taylor K,Stengel W,Casalegno C,et al.Experiences of the REACH testing proposals system to reduce animal testing[J].ALTEX,2014,31(2):107-28.
[3]Tollefsen KE,Scholz S,Cronin MT,et al.Applying adverse outcome pathways(AOPs)to support integrated approaches to testing and assessment(IATA)[J].Regulat Toxicol Pharmacol,2014,70:629-40.
[4]Wong CL,Ghassabian S,Smith MT et al.In vitro methods for hazard assessment of industrial chemicals-opportunities and challenges[J].Frontier Pharmacol,2015,6.
[5]Adler S,Basketter D,Creton S,et al.Alternative(non-animal)methods for cosmetics testing:current status and future prospects[J].Arch Toxicol,2011,85:367-485.
[6]Goebel C,Aeby P,Ade N,et al.Guiding principles for the implementation of non-animal safety assessment approaches for cosmetics:skin sensitization[J].Regulat Toxicol Pharmacol,2012,93:40-52.
[7]Lee S,Dong DX,Jindal R,et al.Predicting full thickness skin sensitization using a support vector machine.Toxicol in Vitro,2014,28(8):1413-23.
[8]Fukunaga A,Khaskhely NM,Sreevidya CS,et al.Dermal dendritic cells,and non Langerhans cells,play an essential role in inducing and immune response[J].J Immunol,2008,180(5):3057-64.
[9]Maxwell G,Aeby P,Ashikaga T,et al.Skin sensitization:the Colipa strategy for developing and evaluating non-animal test methods for risk assessment[J].ALTEX,2011,28(1):50-5.
[10]Piroird C,Ovigne JM,Rousset F,et al.The myeloid U937 skin sensitization test(U-SENS)addresses the activation of dendritic cell events in the adverse outcome pathway for skin sensitization[J].Toxicol In Vitro,2015,29(5):901-16.
[11]Python F,Goebel C Aeby P.Comparative DNA microarray analysis of human monocyte derived dendritic cells and MUTZ-3 cells exposed to the moderate skin sensitizer cinnamaldehyde[J].Tocol Appl Pharmacol,2009,239(3):273-83.
[12]Chapman VL,Terranova R,Moggs JG,et al.Evaluation of5-methylcytosine and 5-hydroxyl-methylcytosine as potential biomarkers for characterization of chemical allergens[J].Toxicol,2016,340:17-26.
[13]Novak N,Valenta R,Bohle B,et al.FcεRI engagement of Langerhans cell-like dendritic cells and inflammatory dendritic epidermal cell-like cells induces chemotactic signals and different T-cell phenotypes in vitro[J].JAllergy Clin Immunol,2004,113(5):949-57.
[14]Nayak A,Hettick JM,Siegel PD,et al.Toluene diisocyanate(TDI)disposition and co-localization of immune cells in hair follicles[J].Toxicol Sci,2014,140(2):327-37.
[15]吴玉霞,符移才.多化学物质过敏症及其所致变应性皮肤敏感[J].环境与职业医学,2016,33(4):408-12.
[16]Karlsson I,Samuelsson K,Ponting DJ,et al.Peptide Reactivity of Isothiocyanates-Implications for Skin Allergy[J].Sci Rep,2016,6.
[17]Kandarova H,Letasiova S.Alternative methods in toxicology:pre-validated and validated methods[J].Interdiscip Toxicol,2011,4(3):107-13.
[18]Dalod M,Chelbi R,Malissen B,et al.Dendritic cell maturation:functional specialization through signaling specificity and transcriptional programming[J].EMBO J,2014,33(10):1104-16.
[19]Novak N,Gros E,Bieber T,et al.Human skin and oral mucosal dendritic cells as‘good guys’and‘bad guys’in allergic immune responses[J].Clin Exp Immunol,2010,161:28-33.
[20]Clausen BE,Stoitzner B.Functional specialization of skin dendritic cell subsets in regulating T cell responses[J].Front Immunol,2015,6:534.
[21]Luo YC,Cai XN,Liu SC,et al.Suppression of antigen-specific adaptive immunity by IL-37 via induction of tolerogenic dendritic cells[J].PNAS,2014,111(42):15178-83.
[22]Liu WH,Liu JJ,Wu J,et al.Novel mechanism of inhibition of dendritic cells maturation by mesenchymal stem cells via interleukin-10 and the JAK1/STAT3 signaling pathway[J].PLOS one,2013,8(1).
[23]Fu YC,Jin XP,Wei SM,et al.Ultraviolet radiation and reactive oxygen generation as inducers of keratinocyte apoptosis:protective role of tea polyphenols[J].J Toxicol Environ Health A,2000,61(3):177-88.
[24]Hameed I,Masoodi SR,Mir SA,et al.Type 2 diabetes mellitus:From a metabolic disorder to an inflammatory condition[J].World J Diabetes 2015,6(4):598-612.
[25]Kowalewski C,Kurpios-Pieca D,Rahden-Staron I,et al.The potential role of NK-k B activation and synthesis of pro-inflammatory mediators in the pathogenesis of allergic contact dermatitis induced by thiuram[J].Clin Translational Allergy,2015,5.