静息态功能磁共振成像对36小时睡眠剥夺健康成年男性情绪功能网络影响的研究
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摘要
目的运用静息态功能磁共振成像(rs-fMRI)技术,探讨睡眠剥夺(SD)对健康成年男性情绪功能网络的影响及其可能的神经机制。方法采用自身前后对照设计,30名健康成年男性分别于正常睡眠后及36 h SD后进行rs-fMRI扫描。选取双侧杏仁核为种子区域,采用功能连接的分析方法,比较SD前后双侧杏仁核种子点与全脑功能连接的变化情况。结果 SD导致内侧前额叶、楔前叶与杏仁核功能连接增强(P<0.05);而与丘脑、岛叶之间的功能连接减弱。与36 h SD前相比,SD后POMS得分明显升高,两者差异有统计学意义(t=9.436;P=0.007);双侧杏仁核与内侧前额叶皮质、丘脑间的功能连接与心境状态量表(POMS)得分呈正相关(r=0.614,0.492;P=0.013,0.027;r=0.537,0.453;P=0.021,0.033)。结论 36 h SD后大脑负责情绪调控的双侧杏仁核区功能连接显著改变,主要表现为与内侧前额叶皮质功能连接增强,而与双侧丘脑功能连接减弱;这可能是SD后负性情绪增加,正性情绪下降的重要神经机制。
Objective Functional connectivity analysis was used to analyze the effects of sleep deprivation on the emotional functioning network in healthy adult men under resting state fMRI. Methods Amygdala were selected as seed points. Using resting state fMRI and functional connectivity analysis to compare the whole brain functional connectivity patterns of 30 young healthy male volunteers in the rested wakefulness state and sleep deprivation state. Results Sleep deprivation resulted in a significant increase between the medial prefrontal cortex,anterior wedge and amygdala(P<0.05). The functional connectivity was significantly decreased between amygdala,thalamus and insular.Compared with rested wakefulness state the total score of profile of mood states(POMS) was significantly higher in the sleep deprivation state.The connection between amygdala and the medial prefrontal cortex,thalamus showed positive correlation with the total score of POMS(r=0.614,0.492; P=0.013,0.027; r=0.537,P=0.021; r=0.453,P=0.033). Conclusion SD has a significant effect on amygdala functional connectivity.The functional connectivity between amygdala and the medial prefrontal cortex is significantly increased while that between amygdala and thalamus is decreased after 36 hours SD.This findings may be the essential neural mechanism of negative emotion raised,positive emotion decline induced by sleep deprivation.
Objective Functional connectivity analysis was used to analyze the effects of sleep deprivation on the emotional functioning network in healthy adult men under resting state fMRI. Methods Amygdala were selected as seed points. Using resting state fMRI and functional connectivity analysis to compare the whole brain functional connectivity patterns of 30 young healthy male volunteers in the rested wakefulness state and sleep deprivation state. Results Sleep deprivation resulted in a significant increase between the medial prefrontal cortex,anterior wedge and amygdala(P<0.05). The functional connectivity was significantly decreased between amygdala,thalamus and insular.Compared with rested wakefulness state the total score of profile of mood states(POMS) was significantly higher in the sleep deprivation state.The connection between amygdala and the medial prefrontal cortex,thalamus showed positive correlation with the total score of POMS(r=0.614,0.492; P=0.013,0.027; r=0.537,P=0.021; r=0.453,P=0.033). Conclusion SD has a significant effect on amygdala functional connectivity.The functional connectivity between amygdala and the medial prefrontal cortex is significantly increased while that between amygdala and thalamus is decreased after 36 hours SD.This findings may be the essential neural mechanism of negative emotion raised,positive emotion decline induced by sleep deprivation.
引文
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14 Picó-Pérez M,Alonso P,Contreras-Rodríguez O,et al.Dispositional use of emotion regulation strategies and resting-state cortico-limbic functional connectivity[J].Brain Imaging and Behavior,201812:1022-1031.
15 Chang C,Leopold DA,Sch?lvinck ML,et al.Tracking brain arousal fluctuations with fMRI[J].Proceedings of the National Academy of Sciences of the United States of America,2016,113:4518-4523.
16 Zhu X,Helpman L,Papini S,et al.Altered resting state functional connectivity of fear and reward circuitry in comorbid PTSD and major depression[J].Depression & Anxiety,2016,34:641-650.
17 Guo X,Duan X,Long Z,et al.Decreased amygdala functional connectivity in adolescents with autism:A resting-state fMRI study[J].Psychiatry Research,2016,257:47-56.
2 Janna K,Joel V,Avijit B,et al.The influence of sleep deprivation and oscillating motion on sleepiness,motion sickness,and cognitive and motor performance[J].Auton Neurosci,2017,202:86-96.
3 Oya H,Howarda MA,Magnottab VA,et al.Mapping effective connectivity in the human brain with concurrent intracranial electrical stimulation and BOLD-fMRI [J].Journal of Neuroscience Methods,2016,277:101-112.
4 任继亮,魏新华,刘文华,等.fMRI分析非临床抑郁大学生杏仁核及海马静息态功能连接的改变[J].中国医学影像技术,2015,31:14-18.
5 Ma Y.Neuropsychological mechanism underlying antidepressant effect:a system meta-analysis[J].Mol Psychiatry,2015,20:311-319.
6 张旭,钱若兵,傅先明,等.脑震荡综合征患者情绪网络的静息态fMRI观察[J].中华医学杂志,2017,97:1951-1955.
7 Simon EB,Lahav N,Shamir R,et al.Tired and Misconnected:A Breakdown of Brain Modularity following Sleep Deprivation[J].Human Brain Mapping,2017,81:3300-3314.
8 李自强,秦晔,苏彤,等.睡眠剥夺对个体情绪的影响及其机制[J].第二军医大学学报,2016,37:1397-1401.
9 Short MA,Louca M.Sleep deprivation leads to mood deficits in healthy adolescents[J].Sleep Med,2015,16:987-993.
10 Motomura Y,Kitamura S,Oba K,et al.Correction:Sleep Debt Elicits Negative Emotional Reaction through Diminished Amygdala-Anterior Cingulate Functional Connectivity[J].Plos One,2013,8:e56578.
11 Killgore WD.Self-reported sleep correlates with prefrontal-amygdala functional connectivity and emotional functioning[J].Sleep,2013,36:1597-1608.
12 Motomura Y,Kitamura S,Nakazaki K,et al.Recovery from Unrecognized Sleep Loss Accumulated in Daily Life Improved Mood Regulation via Prefrontal Suppression of Amygdala Activity[J].Frontiers in Neurology,2017,8.306.
13 Reidy BL,Hamann S,Inman C,et al.Decreased sleep duration is associated with increased fMRI responses to emotional faces in children[J].Neuropsychologia,2016,84:54-62.
14 Picó-Pérez M,Alonso P,Contreras-Rodríguez O,et al.Dispositional use of emotion regulation strategies and resting-state cortico-limbic functional connectivity[J].Brain Imaging and Behavior,201812:1022-1031.
15 Chang C,Leopold DA,Sch?lvinck ML,et al.Tracking brain arousal fluctuations with fMRI[J].Proceedings of the National Academy of Sciences of the United States of America,2016,113:4518-4523.
16 Zhu X,Helpman L,Papini S,et al.Altered resting state functional connectivity of fear and reward circuitry in comorbid PTSD and major depression[J].Depression & Anxiety,2016,34:641-650.
17 Guo X,Duan X,Long Z,et al.Decreased amygdala functional connectivity in adolescents with autism:A resting-state fMRI study[J].Psychiatry Research,2016,257:47-56.
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