基因-脑-行为视角下的自伤行为产生机制
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摘要
自伤是遗传与环境共同作用的结果。目前对于自伤行为的探讨已深入到基因及神经系统层面,基因-脑-行为的综合视角为客观揭示自伤产生机制提供了一条有效途径。本文将在已有研究的基础上,结合分子遗传学和神经生物学的最新成果,对自伤候选基因多态性及其可能的脑机制进行系统阐述,并提出今后应在基因多态性的交互作用及其脑机制、积极环境下自伤行为研究、自伤青少年的追踪研究以及自伤行为的系统性探讨等方面进一步深化。
Non-suicidal self-injury( NSSI) refers to the behavior that intentionally and repeatedly harms his or her own body tissues without suicide intention. Its universality and serious consequences have aroused researchers' great attention. NSSI is the result of genetic and environmental interaction. The discussion of individual genetic traits has reached the genetic and neurological level now; the gene-brain-behavioral research paradigm provides an effective way to explore the mechanism of NSSI. In this paper,based on the existing NSSI studies and relevant research results,the polymorphism of candidate genes of NSSZ and its possible brain mechanism were comprehensively elaborated. Future research could focus on the issues of polygene-environment interaction,gene-brain-NSSZ in positive environment,the longitudinal study paradigm among adolescents,and further systematic research.
Non-suicidal self-injury( NSSI) refers to the behavior that intentionally and repeatedly harms his or her own body tissues without suicide intention. Its universality and serious consequences have aroused researchers' great attention. NSSI is the result of genetic and environmental interaction. The discussion of individual genetic traits has reached the genetic and neurological level now; the gene-brain-behavioral research paradigm provides an effective way to explore the mechanism of NSSI. In this paper,based on the existing NSSI studies and relevant research results,the polymorphism of candidate genes of NSSZ and its possible brain mechanism were comprehensively elaborated. Future research could focus on the issues of polygene-environment interaction,gene-brain-NSSZ in positive environment,the longitudinal study paradigm among adolescents,and further systematic research.
引文
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Bogdan,R.,Santesso,D.L.,Fagerness,J.,Perlis,R.H.,&Pizzagalli,D.A.(2011).Corticotropin-releasing hormone receptor type 1(CRHR1)genetic variation and stress interact to influence reward learning.The Journal of Neuroscience,31(37),13246-13254.
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Bresin,K.,Finy,M.S.,&Verona,E.(2013).Childhood emotional environment and self-injurious behaviors:The moderating role of the BDNF Val66Met polymorphism.Journal of Affective Disorders,150(2),594-600.
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Comasco,E.,slund,C.,Oreland,L.,&Nilsson,K.W.(2013).Three-way interaction effect of 5-HTTLPR,BDNF Val66Met,and childhood adversity on depression:A replication study.European Neuropsychopharmacology,23(10),1300-1306.
Crowell,S.E.,Beauchaine,T.P.,&Linehan,M.M.(2009).Abiosocial developmental model of borderline personality:Elaborating and extending linehan’s theory.Psychological Bulletin,135(3),495-510.
Dannlowski,U.,Ohrmann,P.,Konrad,C.,Domschke,K.,Bauer,J.,Kugel,H.,et al.(2009).Reduced amygdala-prefrontal coupling in major depression:Association with MAOA genotype and illness severity.The International Journal of Neuropsychopharmacology,12(1),11-22.
Drabant,E.M.,Hariri,A.R.,Meyer-Lindenberg,A.,Munoz,K.E.,Mattay,V.S.,Kolachana,B.S.,et al.(2006).Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation.Archives of General Psychiatry,63,1396-1406.
Drabant,E.M.,Ramel,W.,Edge,M.D.,Hyde,L.W.,Kuo,J.R.,Goldin,P.R.,et al.(2012).Neural mechanisms underlying 5-HTTLPR-related sensitivity to acute stress.The American Journal of Psychiatry,169(4),397-405.
Ellis,B.J.,Boyce,W.T.,Belsky,J.,Bakermans-Kranenburg,M.J.,&Van IJzendoorn,M.H.(2011).Differential susceptibility to the environment:An evolutionary-neurodevelopmental theory.Development and Psychopathology,23(1),7-28.
Fani,N.,Gutman,D.A.,Tone,E.B.,Almli,L.M.,Mercer,K.B.,Davis,J.S.,et al.(2013).FKBP5 and attention bias for threat:Associations with hippocampal function and shape.JAMA Psychiatry,70(4),392-400.
Fikke,L.T.,Melinder,A.,&Landro,N.I.(2011).Executive functions are impaired in adolescents engaging in non-suicidal self-injury.Psychological Medicine,41(3),601-610.
Forrester,R.L.,Slater,H.,Jomar,K.,Mitzman,S.&,Taylor,P.J.(2017).Self-esteem and non-suicidal self-injury in adulthood:Asystematic review.Journal of Affective Disorders,221,172-183.
Frodl,T.,&O'Keane,V.(2013).How does the brain deal with cumulative stress?A review with focus on developmental stress,HPA axis function and hippocampal structure in humans.Neurobiology of Disease,52,24-37.
Frodl,T.,Schule,C.,Schmitt,G.,Born,C.,Baghai,T.,Zill,P.,et al.(2007).Association of brain-derived neurotrophic factor val66met polymorphism with reduced hippocampal volumes in major depression.Arch Gen Psychiatry,64,410-416.
Gatt,J.M.,Nemeroff,C.B.,Dobson-stone,C.,Paul,R.H.,Bryant,R.A.,Schofield,P.R.,et al.(2009).Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety.Molecular Psychiatry,14(7),681-95.
Gibb,B.E.,Uhrlass,D.J.,Grassia,M.,Benas,J.S.,&Mc Geary,J.(2009).Children’s inferential styles,5-HTTLPR genotype,and maternal expressed emotion-criticism:An integrated model for the intergenerational transmission of depression.Journal of Abnormal Psychology,118,734-745.
Glenn,C.R.,&Klonsky,E.D.(2013).Nonsuicidal self-injury disorder:An empirical investigation in adolescent psychiatric patients.Journal of Clinical Child&Adolescent Psychology,42(4),496-507.
Gratz,K.L.(2006).Risk factors for deliberate self-harm among female college students:The role and interaction of childhood maltreatment,emotional inexpressivity,and affect intensity/reactivity.The American Journal of Orthopsychiatry,76(2),238-250.
Guan,K.,Fox,K.R.,&Prinstein,M.J.(2012).Nonsuicidal selfinjury as a time-invariant predictor of adolescent suicide ideation and attempts in a diverse community sample.Journal of Consulting and Clinical Psychology,80(5),842-849.
Guerry,J.D.,&Prinstein,M.J.(2010).Longitudinal prediction of adolescent nonsuicidal self-Injury:Examination of a cognitive vulnerability-stress model.Journal of Clinical of Child and Adolescent Psychology,39(1),77-89.
Hankin,B.L.,Barrocas,A.L.,Young,J.F.,Haberstick,B.,&Smolen,A.(2015).5-HTTLPR×interpersonal stress interaction and nonsuicidal self-injury in general community sample of youth.Psychiatry Research,225(3),609-612.
Hariri,A.R.,&Holmes,A.(2006).Genetics of emotional regulation:The role of the serotonin transporter in neural function.Trends in Cognitive Sciences,10(4),182-191.
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