不同剂量他汀治疗急性心肌梗死的疗效比较

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英文篇名：Efficacy of different doses of statins in the treatment of acute myocardial infarction:a comparative study 作者：付永勇 ; 胡竹君 英文作者：FU Yong-yong;HU Zhu-jun;Internal Medicine-Cardiovascular Department,Sanmen Hospital of TCM;Internal Medicine-Cardiovascular Department,The People's Hospital of Sanmen; 关键词：急性心肌梗死 ; 他汀类药物 ; 不同剂量 ; 临床疗效 ; 血管再通 英文关键词：acute myocardial infarction;;statins;;different doses;;clinical efficacy;;vascular recanalization 中文刊名：HZYG 英文刊名：Health Research 机构：三门县中医院心内科;三门县人民医院心内科; 出版日期：2019-06-26 14:55 出版单位：健康研究 年：2019 期：v.39;No.186 语种：中文; 页：HZYG201903015 页数：4 CN：03 ISSN：33-1359/R 分类号：63-66

摘要

目的探讨不同剂量他汀药物治疗急性心肌梗死(acute myocardial infarction,AMI)患者的疗效。方法选取70例AMI患者分为小剂量组和大剂量组各35例。AMI患者入院确诊并接受常规内科治疗基础上,小剂量组口服阿托伐他汀20 mg/d,大剂量组口服阿托伐他汀40 mg/d,均持续治疗4 w。观察2组血脂、心功能以及血管再通情况,比较2组心血管不良事件(MACE)发生情况。结果大剂量组治疗后TG、TC、LDL-C、血BNP较小剂量组有明显下降,HDL-C、LVEF显著上升,差异均有统计学意义(均P<0. 05);大剂量组血管再通率(80. 00%)高于小剂量组(57. 14%),差异有统计学意义(P<0. 05);小/大剂量组MACE发生率分别为14. 29%(5/35)、8. 57%(3/35),二者差异无统计学意义(P>0. 05)。结论大剂量他汀类药物能有效改善AMI患者血脂水平和心功能,提高血管再通率,且不增加MACE发生风险。
        Objective To evaluatae the efficacy of different doses of statins in the treatment of acute myocardial infarction( AMI). Methods Firstly,70 AMI patients were randomly divided into two groups,namely,group A( given small dose of statins; n = 35) and group B( given large dose of statins; n = 35). In addition to routine medical treatment,group A( the AMI patients as subjects to treatment with small dose) were given atorvastatin 20 mg/d while group B( those as subjects to treatment with large dose) were given atorvastatin 40 mg/d,for a course of 4 w continuously. Next,the blood lipid,cardiac function and vascular recanalization of the two groups were observed. Lastly,the incidence of cardiovascular adverse events( MACE) in the 2 groups was compared. Results After treatment,the TG,TC,LDL-C and blood BNP of group B was lowered as compared with those of group A. The HDL-C and LVEF of group B were heightened. The differences were statistically significant( P<0.05). The rate of vascular recanalization of group B was 80%,which was higher than that of group A( 57.14%). The difference was statistically significant( P<0.05). The rates of incidence of MACE of group A and group B were 14.29%( 5/35) and 8.57%( 3/35) respectively. The difference was no statistically significant( P> 0.05).Conclusions Large dose of statins can effectively improve the blood lipid level and cardiac function of AMI patients,increase the recanalization rate,and does not increase the risk of MACE.

引文

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