基于中医传承辅助系统治疗儿童肥胖症组方规律分析
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摘要
目的:基于中医传承辅助系统软件,分析中医药治疗儿童肥胖症的组方用药规律。方法:通过中国知识资源总库(CNKI)收集近10年来中医药治疗儿童肥胖症的方剂,应用中医传承辅助系统(V2.5),逐一录入方剂信息,建立方剂数据库,利用软件数据挖掘方法,分析治疗儿童肥胖症方剂的组方规律。结果:共纳入137首相关方剂,涉及155味中药,使用频次前10位的药味为茯苓、白术、泽泻、陈皮、半夏、山楂、炙甘草、大黄、决明子、厚朴,常用药对为白术与茯苓、半夏与陈皮、陈皮与茯苓、茯苓与泽泻等,发现核心药物组合8对,挖掘出新处方共8个。结论:近年来治疗儿童肥胖症组方以健脾祛湿化痰为主;基于熵层次聚类算法的新方以补虚与泻实为主,新方的药物大多为药食同源之品,如茯苓、陈皮、山楂、荷叶、山药等。因儿童治病依从性差,今后食疗将成为治疗儿童肥胖症的一大趋势。
Objective:To summarize and analyze the prescription rules for treating childhood obesity with Chinese medicine according to the traditional Chinese medicine(TCM) inheritance support system. Methods:Chinese prescriptions for treating childhood obesity during the recent 10 years in CNKI were recorded and established the prescription database by TCM inheritance support system(v2.5) to analyze the prescription rules for treating childhood obesity. Results:Total 137 formulas were selected involving 155 herbs. The top10 frequently used herbs including :Fuling(Poriacocos),Baizhu(Rhizoma atractylodismacrocephalae),Zexie(Rhizoma alismatis),Chenpi(Pericarpium citri reticulatae),Banxia(Rhizoma pinelliae),Shanzha(Crataegus pinnatifida),Zhigancao(Radix glycyrrhizae),Dahuang(Rheum officinalebaill),Juemingzi(Cassiaobtusifolia L),Houpu(Cortex magnoliae officinai1 s),the common herbal pairs including:Baizhu(Rhizoma atractylodismacro cephalae) and Fuling(Poriacocos),Banxia(Rhizoma pinelliae) and Chenpi(Pericarpium citri reticulatae),Chenpi(Pericarpium citri reticulatae) and Fuling(Poriacocos),Fuling(Poriacocos) and Zexie(Rhizoma alismatis). Total 8 core herbal pairs and 8 new formulas are evolved. Conclusions:The prescriptions for treating childhood obesity in recent years mainly focused on invigorating the spleen,eliminating the dampness and resolving the phlegm while the new formula with reinforcing the deficiency and reducing the excess based on entropy hierarchical clustering algorithm. Herbs in this new formula mostly could be used as food,such as Fuling(Poriacocos),Chenpi(Pericarpium citri reticulatae),Shanzha(Crataegus pinnatifida),Heye(Nelumbonucifera Gaertn), Shanyao(Dioscoreaoposita Thunb). Due to the poor compliance in child-patients,diet therapy will be a major trend in treating childhood obesity in the future.
Objective:To summarize and analyze the prescription rules for treating childhood obesity with Chinese medicine according to the traditional Chinese medicine(TCM) inheritance support system. Methods:Chinese prescriptions for treating childhood obesity during the recent 10 years in CNKI were recorded and established the prescription database by TCM inheritance support system(v2.5) to analyze the prescription rules for treating childhood obesity. Results:Total 137 formulas were selected involving 155 herbs. The top10 frequently used herbs including :Fuling(Poriacocos),Baizhu(Rhizoma atractylodismacrocephalae),Zexie(Rhizoma alismatis),Chenpi(Pericarpium citri reticulatae),Banxia(Rhizoma pinelliae),Shanzha(Crataegus pinnatifida),Zhigancao(Radix glycyrrhizae),Dahuang(Rheum officinalebaill),Juemingzi(Cassiaobtusifolia L),Houpu(Cortex magnoliae officinai1 s),the common herbal pairs including:Baizhu(Rhizoma atractylodismacro cephalae) and Fuling(Poriacocos),Banxia(Rhizoma pinelliae) and Chenpi(Pericarpium citri reticulatae),Chenpi(Pericarpium citri reticulatae) and Fuling(Poriacocos),Fuling(Poriacocos) and Zexie(Rhizoma alismatis). Total 8 core herbal pairs and 8 new formulas are evolved. Conclusions:The prescriptions for treating childhood obesity in recent years mainly focused on invigorating the spleen,eliminating the dampness and resolving the phlegm while the new formula with reinforcing the deficiency and reducing the excess based on entropy hierarchical clustering algorithm. Herbs in this new formula mostly could be used as food,such as Fuling(Poriacocos),Chenpi(Pericarpium citri reticulatae),Shanzha(Crataegus pinnatifida),Heye(Nelumbonucifera Gaertn), Shanyao(Dioscoreaoposita Thunb). Due to the poor compliance in child-patients,diet therapy will be a major trend in treating childhood obesity in the future.
引文
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[2]方思佳,周时高,何颂华,等.单纯性肥胖中医药治疗进展[J].辽宁中医药大学学报,2016(5):105.
[3]卢朋,李健,唐仕欢,等.中医传承辅助系统软件开发与应用[J].中国实验方剂学杂志,2012,18(9):1-4.
[4]杨洪军,赵亚丽,唐仕欢,等.基于熵方法分析中风病方剂中药物之间的关联度[J].中国中医基础医学杂志,2005,11(9):706-709.
[5]唐仕欢,陈建新,杨洪军,等.基于复杂系统熵聚类方法的中药新药处方发现研究思路[J].世界科学技术-中医药现代化,2009,11(2):225.
[6]陈建新.中医证候的复杂系统建模及其与疾病的相关性研究[D].北京:中国科学院研究生院,2008:114-117.
[7]YANG H J,SHEN D,XU H Y,et al.A new strategy in drug desige of Chinese medicine:theory,method and techniques[J].Chinese Journal of Integrative Medicine,2012,18(11):803-806.
[8]杨洪军,赵亚丽,唐仕欢,等.基于熵方法分析中风病方剂中药物之间的关联度[J].中国中医基础医学杂志,2005,11(9):706-708.
[9]职冬丽,胡洋成.儿童单纯性肥胖症的中医药治疗概况[J].湖南中医杂志,2016,32(7):209.
[10]郭霭春.黄帝内经素问白话解(上)[M].北京:中国中医药出版社,2014:81.
[11]肖培根,李连达,刘勇.中药保健食品安全性评估系统的初步研究[J].中国中药杂志,2005,30(1):10-12.
[12]曹颖.茯苓多糖药理作用的研究[J].中国现代药物应用,2013,7(13):217-218.
[13]阳柳平.研究白术的化学成分及药理作用概况[J].中国医药指南,2012,7(21):607-609.
[14]田婷,陈华,冯亚龙,等.泽泻药理与毒理作用的研究进展[J].中药材,2014,11(11):2103-2107.
[15]吴惠君,欧金龙,池晓玲,等.陈皮药理作用研究概述[J].实用中医内科杂志,2013(17):91-92.
[16]王英荣.半夏在方剂配伍中的作用及现代药理研究[J].中国冶金工业医学杂志,2009,26(5):605.
[17]詹琤琤,段时振,李杰.中药山楂的化学成分与药理作用研究概况[J].湖北中医杂志,2012(12):77-79.
[18]李德芳,王振华,罗峰,等.异甘草素的药理作用研究[J].时珍国医国药,2010,21(2):362-364.
[19]肖渊.甘草的抗抑郁作用及其机理研究[D].北京:北京中医药大学,2009:78.
[20]张翠玲.甘草酸药理作用及临床应用[J].社区医学杂志,2008,20(6):13-14.
[21]邬博,刘彦晶,连丽.大黄的药理作用研究进展[J].中国中医药现代远程教育,2015(20):152-154.
[22]和殿峰.决明子现代药理分析与临床应用[J].中医学报,2012,27(2):199-200.
[23]李国章.和厚朴酚的药理作用[J].亚太传统医药,2012,8(1):162-163.