薏苡化学成分及药理活性研究进展
|
摘要
薏苡(Coix lacryma-jobi L.)为禾本科(Gramineae)科植物薏苡属(Coix L.)草本植物。结合近年来的研究,对中药薏苡的化学成分、药理活性及其质量评价等方面进行了系统的综述,以期为薏苡的进一步研究和开发利用提供参考。
Adlay is a family of Gramineae. The present paper summarises the recent advances in the chemical composition,pharmacological effects and quality evaluation of adlay. The references for research and development of adlay was provided.
Adlay is a family of Gramineae. The present paper summarises the recent advances in the chemical composition,pharmacological effects and quality evaluation of adlay. The references for research and development of adlay was provided.
引文
[1]惠秋沙.薏苡仁的有效成分提取与含量测定方法[J].中外健康文摘,2011,8(28):95-96.
[2]吕峰.我国薏苡仁资源主要品质及薏苡仁活性多糖的研究[D].福州:福建农林大学,2008.
[3]高微微,赵杨景,何春年.我国薏苡属植物种质资源研究概况[J].中草药,2006,37(2):293-295.
[4]赵晓明.薏苡[M].北京:中国林业出版社,2000:60-61.
[5]李国华,彭建明,马洁.良种薏苡在西双版纳引种栽培技术[J].热带农业科技,2004,27(2):34-35.
[6]吴映梅.薏苡仁饮料及面膜的研究与开发[D].贵阳:贵州大学,2015.
[7]Corke H,Huang Y,Li J S.Coix:Overview[J].Encyclopedia of Food Grains,2016:184-189.
[8]Zhu F.Coix:Chemical composition and health effects[J].Trends in Food Science&Technology,2017,61:160-175.
[9]张永辉.裴李岗文化植物类食物加工工具表面淀粉粒研究[D].合肥:中国科学技术大学,2011.
[10]吴雪辉,何淑华,谢炜琴.薏米淀粉的颗粒结构与性质研究[J].中国粮油学报,2004,19(3):35-37.
[11]雷正杰,张忠义,王鹏,等.薏苡仁油脂肪酸组成分析[J].中药材,1999(8):405-405.
[12]Apirattananusorn S,Tongta S,Cui S W,et al.Chemical,molecular,and structural characterization of alkali extractable nonstarch polysaccharides from Job's tears[J].Journal of Agricultural&Food Chemistry,2008,56(18):8549-8557.
[13]YAO Y,ZHU Y,GAO Y,et al.Effect of ultrasonic treatment on immunological activities of polysaccharides from adlay[J].International Journal of Biological Macromolecules,2015,80:246-252.
[14]LIU X,RONG Y Z,ZHANG X,et al.Rapid Determination of total dietary fiber and minerals in Coix seed by near-infrared spectroscopy technology based on variable selection methods[J].Food Analytical Methods,2015,8(7):1607-1617.
[15]LIU X,ZHANG X,RONG Y Z,et al.Rapid determination of fat,protein and amino acid content in Coix seed using nearinfrared spectroscopy technique[J].Food Analytical Methods,2015,8(2):334-342.
[16]刘春兰,周宜君,周恒彦,等.薏苡的开发和利用[J].中央民族大学学报(自然科学版),2001,10(2):182-185.
[17]何晓阳,蔡一林.苡仁营养成分分析[J].中草药,1996(2):88-88.
[18]Numata M,Yamamoto A,Moribayashi A,et al.Antitumor components isolated from the Chinese herbal medicine Coix lachryma-jobi[J].Planta Medica,1994,60(2):356-359.
[19]Fujitani K,Takasaki M,Konoshima T,et al.Inhibitory effect on Epstein-Barr virus activation of benzylifoquinolines[J].Planta Medica,1990,56(6):654-655.
[20]雷正杰,张忠义,王鹏,等.薏苡仁油脂肪酸组成分析[J].中药材,1999(8):405.
[21]乐巍,邱蓉丽,吴德康,等.不同居群薏苡种仁脂肪酸成分的GC-MS分析[J].中药材,2008,31(11):1613-1614.
[22]XI X J,ZHU Y G,TONG Y P,et al.Assessment of the genetic diversity of different Job's tears(Coix lacryma-jobi L.)accessions and the active composition and anticancer effect of its seed oil[J].Plos One,2016,11(4):e0153269.
[23]WANG L,CHEN J,XIE H,et al.Phytochemical profiles and antioxidant activity of adlay varieties[J].Journal of Agricultural&Food Chemistry,2013,61(21):5103-5113.
[24]Zhao M,Zhu D,Sun-Waterhouse D,et al.In vitro and in vivo studies on adlay-derived seed extracts:phenolic profiles,antioxidant activities,serum uric acid suppression,and xanthine oxidase inhibitory effects[J].Journal of Agricultural&Food Chemistry,2014,62(31):7771-7778.
[25]Yukio I,Kenji O,Hiroshi R,et al.A novel antimicrobial substance in etiolated seedlings of lay[J].Biosci Biotechnol Biochem,1993,57(5):866.
[26]李凤云,陈浩然,冯晓东,等.中药薏苡仁抗肿瘤作用的研究[J].实用肿瘤学杂志,1994(3):59.
[27]刘春兰,杨若明,周宜君,等.贵州薏苡无机元素的分析[J].微量元素与健康研究,2004,21(6):40-41.
[28]Choi Y,Jeong H S,Lee J.Antioxidant activity of methanolic extracts from some grains consumed in Korea[J].Food Chemistry,2007,103(1):130-138.
[29]田端华.薏苡仁化学成分[J].国外医学·中医中药分册,1993(15):556.
[30]Haruki Y,Shuichi Y,Hiroaki K,et al.Water-solble gluieans from theseeds of Coix lachryma-jobi[J].Phytochemistry,1986,25(1):129.
[31]Wu T T,Charles A L,Huang T C.Determination of the contents of the main biochemical compounds of Adlay(Coxi lachrymaljobi)[J].Food Chemistry,2007,104(4):1509-1515.
[32]Din-Wen H,Chi-Hao W,Chun-Kuang S,et al.Application of the solvent extraction technique to investigation of the antiinflammatory activity of adlay bran[J].Food Chemistry,2014,145(7):445.
[33]Chung C P,Hsu C Y,Lin J H,et al.Antiproliferative lactams and spiroenone from adlay bran in human breast cancer cell lines[J].Journal of Agricultural&Food Chemistry,2011,59(4):1185-1194.
[34]Lee M Y,Lin H Y,Cheng F,et al.Isolation and characterization of new lactam compounds that inhibit lung and colon cancer cells from adlay(Coix lachryma-jobi L.var.mayuen Stapf)bran[J].Food&Chemical Toxicology,2008,46(6):1933-1939.
[35]Kuo CC,Chiang W,Liu GP,et al.2,2'-Diphenyl-1-picrylhydrazyl radical-scavenging active components from adlay(Coix lachryma-jobi L.var.ma-yuen Stapf)hulls[J].J Agric Food Chem,2002,50(21):5850-5855.
[36]Otsuka H,Takeuchi M,Inoshiri S,et al.Phenolic compounds from Coix lachryma-jobi,var.Ma-yuen[J].Phytochemistry,1989,28(3):883-886.
[37]Hong S S,Choi C W,Choi Y H,et al.Coixlachryside A:A new lignan glycoside from the roots of Coix lachryma-jobi,L.var.ma-yuen,Stapf[J].Phytochemistry Letters,2016,17:152-157.
[38]八木晟,周德文.薏苡仁的抗癌、消炎活性[J].现代药物与临床,1989(2):75-77.
[39]Mitsuhiro N,Atsuko M.Antitumor components isolated from the Chinese herbal medicine Coix lachryma jobi[J].Plant Med,1994,60:356.
[40]李毓,胡笑克.薏苡仁酯对人鼻咽癌细胞裸鼠移植瘤的放射增敏作用[J].华夏医学,2005,18(2):147-148.
[41]LU X,LIU W,WU J,et al.A polysaccharide fraction of adlay seed(Coix lachryma-jobi,L.)induces apoptosis in human non-small cell lung cancer A549 cells[J].Biochemical&Biophysical Research Communications,2013,430(2):846-851.
[42]杨爽,王李梅,王姝麒,等.薏苡化学成分及其活性综述[J].中药材,2011(8):1306-1312.
[43]Li D.The anticancer drug Kang-Lai-Te emulsion for infusion[J].Vestn Ross Akad Med Nauk,2005(9):32-37.
[44]韩苏夏,朱青,杜蓓茹,等.薏苡仁酯诱导人宫颈癌He La细胞凋亡的实验研究[J].肿瘤,2002,22(6):481-482.
[45]尹蓓珮,严萍萍,刘畅,等.薏苡仁油注射液对人体肝癌SMMC-7721细胞株体外抗肿瘤作用及机制研究[J].现代肿瘤医学,2012,20(4):693-698.
[46]LU Y,ZHANG B Y,JIA Z X,et al.Hepatocellular carcinoma Hep G2 cell apoptosis and caspase-8 and Bcl-2 expression induced by injectable seed extract of Coix lacryma-jobi[J].Hepatobiliary&Pancreatic Diseases International,2011,10(3):303-307.
[47]TAN H,LI Y,YU L.Analgesic action of Kanglaite injection and its effects on levels of TNF-αand IL-Iβin inflamed skin in a rat model of persistent inflammatory pain[J].Chinese Journal of Surgery of Integrated Traditional&Western Medicine,2007,2:29.
[48]杨念婉.两种薏苡产量和药食用品质的形成及其调控研究[D].北京:中国协和医科大学,2010.
[49]张明发,沈雅琴.薏苡仁镇痛抗炎抗血栓形成作用的研究[J].现代中药研究与实践,1998(2):36-38.
[50]Sz-jie Wu,Jong-Yi Fang,Chang-Chai Ng,et al.Antiinflammatory activity of Lactobacillu-fermented adlaysoymilk in LPS-induced macrophages through suppression of NF-κB pathways[J].Food Research International,2013,52(1):262-268.
[51]Nishimura M,Ohkawara T,Kagami-Katsuyama H,et al.Alteration of intestinal flora by the intake of enzymatic degradation products of adlay(Coix lachryma-jobi,L.var.mayuen,Stapf)with improvement of skin condition[J].Journal of Functional Foods,2014,7(2):487-494.
[52]Chen H J,Hsu H Y,Chiang W.Allergic immune-regulatory effects of adlay bran on an OVA-immunized mice allergic model[J].Food&Chemical Toxicology,2012,50(10):3808-3813.
[53]徐梓辉,周世文,黄林清.薏苡仁多糖的分离提取及其降血糖作用的研究[J].第三军医大学学报,2000,22(6):578-581.
[54]Huang BW,Chiang MT,Yao HT,et al.The effect of adlay oil on plasma lipids,insulin and leptin in rat[J].Phytomedicine,2005,12(6-7):433-439.
[55]Kim S O,Yun S J,Jung B,et al.Hypolipidemic effects of crude extract of adlay seed(Coix lachryma-jobi var.mayuen),in obesity rat fed high fat diet:Relations of TNF-αand leptin m RNA expressions and serum lipid levels[J].Life Sciences,2004,75(11):1391-1404.
[55]叶敏.薏苡仁水提液对免疫抑制小鼠免疫功能的影响[J].安徽医药,2006,10(10):727-729.
[56]Shih C K,Chiang W,Kuo M L.Effects of adlay on azoxymethane-induced colon carcinogenesis in rats[J].Food&Chemical Toxicology,2004,42(8):1339-1347.
[58]苗明三.薏苡仁多糖对环磷酰胺致免疫抑制小鼠免疫功能的影响[J].中医药学报,2002,30(5):49-50.
[59]Hsu H Y,Lin B F,Lin J Y,et al.Suppression of allergic reactions by dehulled adlay in association with the balance of TH1/TH2 cell responses[J].Journal of Agricultural&Food Chemistry,2003,51(13):3763-3769.
[60]Yukio Ishiguro,Kenji Okamoto,Hideki Sakamoto,et al.a novel antimicrobial substance in etiolated seedlings of adlay[J].Biosoience,Biotechnology,and Biochemistry,2014,57(5):866.
[61]罗继.薏苡抗菌蛋白组的分离鉴定[D].成都:四川师范大学,2008.
[62]Ishiguro Y,Okamoto K,Sakamoto H,et al.A novel antimicrobial substance in etiolated seedlings of adlay[J].Bioscience Biotechnology&Biochemistry,2008,57(7):1139-1140.
[63]张明发,沈雅琴.薏苡仁的消化系统药理研究[J].现代中药研究与实践,1998(4):36-38.
[64]刘春兰,周宜君,巴特.薏苡多糖的提取及其单糖组分的分析[J].中央民族大学学报(自然科学版),2005,14(1):49-52.
[65]单国顺.薏苡仁炮制工艺及质量标准规范化研究[D].沈阳:辽宁中医药大学,2010.
[66]刘路,高旋,杨永健.HPLC-电雾式检测器的应用[J].中国医药工业杂志,2012,43(3):227-231.
[67]李恃圻,赵晓蕾,张思强,等.薏苡多糖的提取及其抗氧化性[J].食品研究与开发,2012,33(11):84-86.
[68]李洋洋,韩迪,闫宝松,等.不同品系猴头菇子实体中总酚含量测定[J].食品研究与开发,2017,38(4):123-126.
[69]WANG L,CHEN J,XIE H,et al.Phytochemical profiles and antioxidant activity of adlay varieties[J].Journal of Agricultural&Food Chemistry,2013,61(21):5103-5113.
[70]张腊腊,胡浩斌,王宗博,等.紫外分光光度法测定甘草渣中总黄酮含量[J].安徽农业科学,2017,45(9):123-124.
[71]李满秀,白宝林,张晓丽,等.胶束增敏荧光法测定山楂中总黄酮含量[J].光谱实验室,2006,23(4):690-693.
[72]肖晶,马双成.银杏叶中总黄酮含量的考察[J].药物分析杂志,1998(s1):17-18.
[73]李运,张霁,徐福荣,等.红外光谱结合化学计量学对三七总黄酮含量的快速预测研究[J].光谱学与光谱分析,2017,37(1):70-74.
[74]乐薇,吴士筠.Al Cl3比色法测定箬叶总黄酮含量[J].黑龙江农业科学,2015(2):98-101.
[75]Hong-Jhang C,Cheng-Pei C,Wenchang C,et al.Antiinflammatory effects and chemical study of a flavonoid-enriched fraction from adlay bran[J].Food Chemistry,2011,126(4):1741-1748.
[76]王立峰.薏米中多酚类物质对抗氧化、抗肿瘤和降血脂作用的评价研究[D].无锡:江南大学,2012.
[77]陈思颖,杨传玉,胡珺,等.不同产地天麻药材总灰分及浸出物含量分析[J].贵阳医学院学报,2016,41(8):887-890.
[78]程晓宏,杨清华,陈峰,等.食品安全中重金属检测方法的研究进展[J].江苏预防医学,2015(3):56-58.
[79]王玉弢.食品中重金属检测方法研究探讨[J].科技视界,2014(27):358.
[80]范蕾,王建伟,余华丽,等.薏苡仁中5种重金属元素的含量测定[J].中华中医药学刊,2014,32(4):917-918.
[81]梁艺馨,刘康书,蔡秋,等.连续光源火焰原子吸收法同时测定薏苡中铜、铁、钙和锰的不确定度评价[J].食品科学,2016,37(12):134-138.
[82]画红顺,景全成.硫磺熏蒸中药材二氧化硫残留量的分析[J].中医临床研究,2011,3(14):109-110.
[83]Kan W L T,Ma B,Ge L.Sulfur fumigation processing of traditional Chinese medicinal herbs:Beneficial or detrimental[J].Frontiers in Pharmacology,2011,2:84.
[84]丁云连,王琴,曹秋琴,等.蒸馏碘量法测定辣椒、胡椒、八角、孜然及花椒中二氧化硫残留量的探讨[J].中国调味品,2017,42(1):144-147.
[85]祖文川,汪雨,张裕祥,等.蒸馏-高分辨连续光源原子吸收光谱法测定果脯中二氧化硫[J].光谱学与光谱分析,2016,36(4):1221-1224.
[86]顾娉婷.蜜饯果脯类食品中二氧化硫测定方法研究分析[J].安徽农业科学,2016,44(14):107-108.
[87]孔庆怡,赵玉江,金星.中药材中重金属检测及脱除技术研究进展[J].中国现代中药,2008,10(1):3-7.
[88]谢嘉驰,夏伯候,廖端芳,等.中药二氧化硫残留检测的前处理技术研究进展[J].中国药房,2017,28(18):2585-2588.
[89]王立闱,范军,吴国华,等.在线凝胶色谱-串联三重四极杆质谱法测定大豆油中42种农药残留[J].质谱学报,2016,37(4):374-384.
[90]周萍萍,陈惠京,赵云峰,等.动物性食品中持久性有机氯农药的残留分析[J].中国食品卫生杂志,2010,22(3):193-198.
[91]陈笑梅,胡贝贞,刘海山,等.高效液相色谱-串联质谱法测定粮谷中9种氨基甲酸酯类农药残留[J].分析化学,2007,35(1):106-110.
[92]罗彦波,李翔宇,朱风鹏,等.在线GPC-GC-MS/MS法直接检测烟叶中的农药残留[J].烟草科技,2016,49(9):63-66.
[93]王天玉,武秀停,赵静,等.固相萃取-气相色谱法测定薏苡仁、白茯苓和山药中的草甘膦残留[J].分析科学学报,2014,30(1):63-66.
[94]潘孝博,伊雄海,时逸吟,等.液相色谱-高分辨飞行时间质谱法快速筛查食品中香港规例农药残留[J].分析化学,2016,44(7):1125-1132.
[95]曹红娣.蔬菜和水果中23种农药残留的检测[J].上海农业科技,2017(4):41-42.
[96]王孝辉,宛晓春,侯如燕.茶叶中吡虫啉农药残留的液相色谱检测方法[J].茶叶科学,2012,32(3):203-209.
[2]吕峰.我国薏苡仁资源主要品质及薏苡仁活性多糖的研究[D].福州:福建农林大学,2008.
[3]高微微,赵杨景,何春年.我国薏苡属植物种质资源研究概况[J].中草药,2006,37(2):293-295.
[4]赵晓明.薏苡[M].北京:中国林业出版社,2000:60-61.
[5]李国华,彭建明,马洁.良种薏苡在西双版纳引种栽培技术[J].热带农业科技,2004,27(2):34-35.
[6]吴映梅.薏苡仁饮料及面膜的研究与开发[D].贵阳:贵州大学,2015.
[7]Corke H,Huang Y,Li J S.Coix:Overview[J].Encyclopedia of Food Grains,2016:184-189.
[8]Zhu F.Coix:Chemical composition and health effects[J].Trends in Food Science&Technology,2017,61:160-175.
[9]张永辉.裴李岗文化植物类食物加工工具表面淀粉粒研究[D].合肥:中国科学技术大学,2011.
[10]吴雪辉,何淑华,谢炜琴.薏米淀粉的颗粒结构与性质研究[J].中国粮油学报,2004,19(3):35-37.
[11]雷正杰,张忠义,王鹏,等.薏苡仁油脂肪酸组成分析[J].中药材,1999(8):405-405.
[12]Apirattananusorn S,Tongta S,Cui S W,et al.Chemical,molecular,and structural characterization of alkali extractable nonstarch polysaccharides from Job's tears[J].Journal of Agricultural&Food Chemistry,2008,56(18):8549-8557.
[13]YAO Y,ZHU Y,GAO Y,et al.Effect of ultrasonic treatment on immunological activities of polysaccharides from adlay[J].International Journal of Biological Macromolecules,2015,80:246-252.
[14]LIU X,RONG Y Z,ZHANG X,et al.Rapid Determination of total dietary fiber and minerals in Coix seed by near-infrared spectroscopy technology based on variable selection methods[J].Food Analytical Methods,2015,8(7):1607-1617.
[15]LIU X,ZHANG X,RONG Y Z,et al.Rapid determination of fat,protein and amino acid content in Coix seed using nearinfrared spectroscopy technique[J].Food Analytical Methods,2015,8(2):334-342.
[16]刘春兰,周宜君,周恒彦,等.薏苡的开发和利用[J].中央民族大学学报(自然科学版),2001,10(2):182-185.
[17]何晓阳,蔡一林.苡仁营养成分分析[J].中草药,1996(2):88-88.
[18]Numata M,Yamamoto A,Moribayashi A,et al.Antitumor components isolated from the Chinese herbal medicine Coix lachryma-jobi[J].Planta Medica,1994,60(2):356-359.
[19]Fujitani K,Takasaki M,Konoshima T,et al.Inhibitory effect on Epstein-Barr virus activation of benzylifoquinolines[J].Planta Medica,1990,56(6):654-655.
[20]雷正杰,张忠义,王鹏,等.薏苡仁油脂肪酸组成分析[J].中药材,1999(8):405.
[21]乐巍,邱蓉丽,吴德康,等.不同居群薏苡种仁脂肪酸成分的GC-MS分析[J].中药材,2008,31(11):1613-1614.
[22]XI X J,ZHU Y G,TONG Y P,et al.Assessment of the genetic diversity of different Job's tears(Coix lacryma-jobi L.)accessions and the active composition and anticancer effect of its seed oil[J].Plos One,2016,11(4):e0153269.
[23]WANG L,CHEN J,XIE H,et al.Phytochemical profiles and antioxidant activity of adlay varieties[J].Journal of Agricultural&Food Chemistry,2013,61(21):5103-5113.
[24]Zhao M,Zhu D,Sun-Waterhouse D,et al.In vitro and in vivo studies on adlay-derived seed extracts:phenolic profiles,antioxidant activities,serum uric acid suppression,and xanthine oxidase inhibitory effects[J].Journal of Agricultural&Food Chemistry,2014,62(31):7771-7778.
[25]Yukio I,Kenji O,Hiroshi R,et al.A novel antimicrobial substance in etiolated seedlings of lay[J].Biosci Biotechnol Biochem,1993,57(5):866.
[26]李凤云,陈浩然,冯晓东,等.中药薏苡仁抗肿瘤作用的研究[J].实用肿瘤学杂志,1994(3):59.
[27]刘春兰,杨若明,周宜君,等.贵州薏苡无机元素的分析[J].微量元素与健康研究,2004,21(6):40-41.
[28]Choi Y,Jeong H S,Lee J.Antioxidant activity of methanolic extracts from some grains consumed in Korea[J].Food Chemistry,2007,103(1):130-138.
[29]田端华.薏苡仁化学成分[J].国外医学·中医中药分册,1993(15):556.
[30]Haruki Y,Shuichi Y,Hiroaki K,et al.Water-solble gluieans from theseeds of Coix lachryma-jobi[J].Phytochemistry,1986,25(1):129.
[31]Wu T T,Charles A L,Huang T C.Determination of the contents of the main biochemical compounds of Adlay(Coxi lachrymaljobi)[J].Food Chemistry,2007,104(4):1509-1515.
[32]Din-Wen H,Chi-Hao W,Chun-Kuang S,et al.Application of the solvent extraction technique to investigation of the antiinflammatory activity of adlay bran[J].Food Chemistry,2014,145(7):445.
[33]Chung C P,Hsu C Y,Lin J H,et al.Antiproliferative lactams and spiroenone from adlay bran in human breast cancer cell lines[J].Journal of Agricultural&Food Chemistry,2011,59(4):1185-1194.
[34]Lee M Y,Lin H Y,Cheng F,et al.Isolation and characterization of new lactam compounds that inhibit lung and colon cancer cells from adlay(Coix lachryma-jobi L.var.mayuen Stapf)bran[J].Food&Chemical Toxicology,2008,46(6):1933-1939.
[35]Kuo CC,Chiang W,Liu GP,et al.2,2'-Diphenyl-1-picrylhydrazyl radical-scavenging active components from adlay(Coix lachryma-jobi L.var.ma-yuen Stapf)hulls[J].J Agric Food Chem,2002,50(21):5850-5855.
[36]Otsuka H,Takeuchi M,Inoshiri S,et al.Phenolic compounds from Coix lachryma-jobi,var.Ma-yuen[J].Phytochemistry,1989,28(3):883-886.
[37]Hong S S,Choi C W,Choi Y H,et al.Coixlachryside A:A new lignan glycoside from the roots of Coix lachryma-jobi,L.var.ma-yuen,Stapf[J].Phytochemistry Letters,2016,17:152-157.
[38]八木晟,周德文.薏苡仁的抗癌、消炎活性[J].现代药物与临床,1989(2):75-77.
[39]Mitsuhiro N,Atsuko M.Antitumor components isolated from the Chinese herbal medicine Coix lachryma jobi[J].Plant Med,1994,60:356.
[40]李毓,胡笑克.薏苡仁酯对人鼻咽癌细胞裸鼠移植瘤的放射增敏作用[J].华夏医学,2005,18(2):147-148.
[41]LU X,LIU W,WU J,et al.A polysaccharide fraction of adlay seed(Coix lachryma-jobi,L.)induces apoptosis in human non-small cell lung cancer A549 cells[J].Biochemical&Biophysical Research Communications,2013,430(2):846-851.
[42]杨爽,王李梅,王姝麒,等.薏苡化学成分及其活性综述[J].中药材,2011(8):1306-1312.
[43]Li D.The anticancer drug Kang-Lai-Te emulsion for infusion[J].Vestn Ross Akad Med Nauk,2005(9):32-37.
[44]韩苏夏,朱青,杜蓓茹,等.薏苡仁酯诱导人宫颈癌He La细胞凋亡的实验研究[J].肿瘤,2002,22(6):481-482.
[45]尹蓓珮,严萍萍,刘畅,等.薏苡仁油注射液对人体肝癌SMMC-7721细胞株体外抗肿瘤作用及机制研究[J].现代肿瘤医学,2012,20(4):693-698.
[46]LU Y,ZHANG B Y,JIA Z X,et al.Hepatocellular carcinoma Hep G2 cell apoptosis and caspase-8 and Bcl-2 expression induced by injectable seed extract of Coix lacryma-jobi[J].Hepatobiliary&Pancreatic Diseases International,2011,10(3):303-307.
[47]TAN H,LI Y,YU L.Analgesic action of Kanglaite injection and its effects on levels of TNF-αand IL-Iβin inflamed skin in a rat model of persistent inflammatory pain[J].Chinese Journal of Surgery of Integrated Traditional&Western Medicine,2007,2:29.
[48]杨念婉.两种薏苡产量和药食用品质的形成及其调控研究[D].北京:中国协和医科大学,2010.
[49]张明发,沈雅琴.薏苡仁镇痛抗炎抗血栓形成作用的研究[J].现代中药研究与实践,1998(2):36-38.
[50]Sz-jie Wu,Jong-Yi Fang,Chang-Chai Ng,et al.Antiinflammatory activity of Lactobacillu-fermented adlaysoymilk in LPS-induced macrophages through suppression of NF-κB pathways[J].Food Research International,2013,52(1):262-268.
[51]Nishimura M,Ohkawara T,Kagami-Katsuyama H,et al.Alteration of intestinal flora by the intake of enzymatic degradation products of adlay(Coix lachryma-jobi,L.var.mayuen,Stapf)with improvement of skin condition[J].Journal of Functional Foods,2014,7(2):487-494.
[52]Chen H J,Hsu H Y,Chiang W.Allergic immune-regulatory effects of adlay bran on an OVA-immunized mice allergic model[J].Food&Chemical Toxicology,2012,50(10):3808-3813.
[53]徐梓辉,周世文,黄林清.薏苡仁多糖的分离提取及其降血糖作用的研究[J].第三军医大学学报,2000,22(6):578-581.
[54]Huang BW,Chiang MT,Yao HT,et al.The effect of adlay oil on plasma lipids,insulin and leptin in rat[J].Phytomedicine,2005,12(6-7):433-439.
[55]Kim S O,Yun S J,Jung B,et al.Hypolipidemic effects of crude extract of adlay seed(Coix lachryma-jobi var.mayuen),in obesity rat fed high fat diet:Relations of TNF-αand leptin m RNA expressions and serum lipid levels[J].Life Sciences,2004,75(11):1391-1404.
[55]叶敏.薏苡仁水提液对免疫抑制小鼠免疫功能的影响[J].安徽医药,2006,10(10):727-729.
[56]Shih C K,Chiang W,Kuo M L.Effects of adlay on azoxymethane-induced colon carcinogenesis in rats[J].Food&Chemical Toxicology,2004,42(8):1339-1347.
[58]苗明三.薏苡仁多糖对环磷酰胺致免疫抑制小鼠免疫功能的影响[J].中医药学报,2002,30(5):49-50.
[59]Hsu H Y,Lin B F,Lin J Y,et al.Suppression of allergic reactions by dehulled adlay in association with the balance of TH1/TH2 cell responses[J].Journal of Agricultural&Food Chemistry,2003,51(13):3763-3769.
[60]Yukio Ishiguro,Kenji Okamoto,Hideki Sakamoto,et al.a novel antimicrobial substance in etiolated seedlings of adlay[J].Biosoience,Biotechnology,and Biochemistry,2014,57(5):866.
[61]罗继.薏苡抗菌蛋白组的分离鉴定[D].成都:四川师范大学,2008.
[62]Ishiguro Y,Okamoto K,Sakamoto H,et al.A novel antimicrobial substance in etiolated seedlings of adlay[J].Bioscience Biotechnology&Biochemistry,2008,57(7):1139-1140.
[63]张明发,沈雅琴.薏苡仁的消化系统药理研究[J].现代中药研究与实践,1998(4):36-38.
[64]刘春兰,周宜君,巴特.薏苡多糖的提取及其单糖组分的分析[J].中央民族大学学报(自然科学版),2005,14(1):49-52.
[65]单国顺.薏苡仁炮制工艺及质量标准规范化研究[D].沈阳:辽宁中医药大学,2010.
[66]刘路,高旋,杨永健.HPLC-电雾式检测器的应用[J].中国医药工业杂志,2012,43(3):227-231.
[67]李恃圻,赵晓蕾,张思强,等.薏苡多糖的提取及其抗氧化性[J].食品研究与开发,2012,33(11):84-86.
[68]李洋洋,韩迪,闫宝松,等.不同品系猴头菇子实体中总酚含量测定[J].食品研究与开发,2017,38(4):123-126.
[69]WANG L,CHEN J,XIE H,et al.Phytochemical profiles and antioxidant activity of adlay varieties[J].Journal of Agricultural&Food Chemistry,2013,61(21):5103-5113.
[70]张腊腊,胡浩斌,王宗博,等.紫外分光光度法测定甘草渣中总黄酮含量[J].安徽农业科学,2017,45(9):123-124.
[71]李满秀,白宝林,张晓丽,等.胶束增敏荧光法测定山楂中总黄酮含量[J].光谱实验室,2006,23(4):690-693.
[72]肖晶,马双成.银杏叶中总黄酮含量的考察[J].药物分析杂志,1998(s1):17-18.
[73]李运,张霁,徐福荣,等.红外光谱结合化学计量学对三七总黄酮含量的快速预测研究[J].光谱学与光谱分析,2017,37(1):70-74.
[74]乐薇,吴士筠.Al Cl3比色法测定箬叶总黄酮含量[J].黑龙江农业科学,2015(2):98-101.
[75]Hong-Jhang C,Cheng-Pei C,Wenchang C,et al.Antiinflammatory effects and chemical study of a flavonoid-enriched fraction from adlay bran[J].Food Chemistry,2011,126(4):1741-1748.
[76]王立峰.薏米中多酚类物质对抗氧化、抗肿瘤和降血脂作用的评价研究[D].无锡:江南大学,2012.
[77]陈思颖,杨传玉,胡珺,等.不同产地天麻药材总灰分及浸出物含量分析[J].贵阳医学院学报,2016,41(8):887-890.
[78]程晓宏,杨清华,陈峰,等.食品安全中重金属检测方法的研究进展[J].江苏预防医学,2015(3):56-58.
[79]王玉弢.食品中重金属检测方法研究探讨[J].科技视界,2014(27):358.
[80]范蕾,王建伟,余华丽,等.薏苡仁中5种重金属元素的含量测定[J].中华中医药学刊,2014,32(4):917-918.
[81]梁艺馨,刘康书,蔡秋,等.连续光源火焰原子吸收法同时测定薏苡中铜、铁、钙和锰的不确定度评价[J].食品科学,2016,37(12):134-138.
[82]画红顺,景全成.硫磺熏蒸中药材二氧化硫残留量的分析[J].中医临床研究,2011,3(14):109-110.
[83]Kan W L T,Ma B,Ge L.Sulfur fumigation processing of traditional Chinese medicinal herbs:Beneficial or detrimental[J].Frontiers in Pharmacology,2011,2:84.
[84]丁云连,王琴,曹秋琴,等.蒸馏碘量法测定辣椒、胡椒、八角、孜然及花椒中二氧化硫残留量的探讨[J].中国调味品,2017,42(1):144-147.
[85]祖文川,汪雨,张裕祥,等.蒸馏-高分辨连续光源原子吸收光谱法测定果脯中二氧化硫[J].光谱学与光谱分析,2016,36(4):1221-1224.
[86]顾娉婷.蜜饯果脯类食品中二氧化硫测定方法研究分析[J].安徽农业科学,2016,44(14):107-108.
[87]孔庆怡,赵玉江,金星.中药材中重金属检测及脱除技术研究进展[J].中国现代中药,2008,10(1):3-7.
[88]谢嘉驰,夏伯候,廖端芳,等.中药二氧化硫残留检测的前处理技术研究进展[J].中国药房,2017,28(18):2585-2588.
[89]王立闱,范军,吴国华,等.在线凝胶色谱-串联三重四极杆质谱法测定大豆油中42种农药残留[J].质谱学报,2016,37(4):374-384.
[90]周萍萍,陈惠京,赵云峰,等.动物性食品中持久性有机氯农药的残留分析[J].中国食品卫生杂志,2010,22(3):193-198.
[91]陈笑梅,胡贝贞,刘海山,等.高效液相色谱-串联质谱法测定粮谷中9种氨基甲酸酯类农药残留[J].分析化学,2007,35(1):106-110.
[92]罗彦波,李翔宇,朱风鹏,等.在线GPC-GC-MS/MS法直接检测烟叶中的农药残留[J].烟草科技,2016,49(9):63-66.
[93]王天玉,武秀停,赵静,等.固相萃取-气相色谱法测定薏苡仁、白茯苓和山药中的草甘膦残留[J].分析科学学报,2014,30(1):63-66.
[94]潘孝博,伊雄海,时逸吟,等.液相色谱-高分辨飞行时间质谱法快速筛查食品中香港规例农药残留[J].分析化学,2016,44(7):1125-1132.
[95]曹红娣.蔬菜和水果中23种农药残留的检测[J].上海农业科技,2017(4):41-42.
[96]王孝辉,宛晓春,侯如燕.茶叶中吡虫啉农药残留的液相色谱检测方法[J].茶叶科学,2012,32(3):203-209.