白芨胶对皮肤皲裂大鼠血清中白细胞介素表达影响
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摘要
目的:初步探讨白芨胶对皮肤皲裂大鼠血清白介素表达的影响,为白芨的临床使用提供依据。方法:在大鼠背部涂抹5 mol/l氢氧化钠建立皮肤皲裂模型,给予不同药物治疗;采用ELISA法检测大鼠血清中炎性因子白细胞介素IL-6,IL-10的表达;对所得数据进行单因素方差分析。结果:白芨胶在2.5%、5%、7.5%剂量时,能够有效降低皮肤皲裂大鼠血清中炎性因子白细胞介素IL-6,IL-10的含量。结论:白芨胶在2.5%、5%、7.5%剂量时,都够有效治疗皮肤皲裂病的症状,其中5%白芨胶的效果最好。
Objective: To investigate the effect of bletilla gum on serum interleukin expression in chapped rats of skin, and to provide basis for clinical use of Bleilla Striata(Thumb) Reichb.f. Methods: The skin chapped model was established by applying 5 mol/l sodium hydroxide to the back of rats, and different drugs were given, and the expression of inflammatory factor interleukin IL-6, IL-10 in serum of rats was detected by ELISA method, and the data were analyzed by one-way ANOVA. Results: Bletilla gum can effectively reduce the content of inflammatory factor interleukin IL-6, IL-10 in serum of chapped rats at 2.5%, 5% and7.5% doses. Conclusion: Bletilla gum in 2.5%, 5%, 7.5% doses, are effective enough to treat the symptoms of chapped skin disease, of which 5% bletilla glue effect is the best.
Objective: To investigate the effect of bletilla gum on serum interleukin expression in chapped rats of skin, and to provide basis for clinical use of Bleilla Striata(Thumb) Reichb.f. Methods: The skin chapped model was established by applying 5 mol/l sodium hydroxide to the back of rats, and different drugs were given, and the expression of inflammatory factor interleukin IL-6, IL-10 in serum of rats was detected by ELISA method, and the data were analyzed by one-way ANOVA. Results: Bletilla gum can effectively reduce the content of inflammatory factor interleukin IL-6, IL-10 in serum of chapped rats at 2.5%, 5% and7.5% doses. Conclusion: Bletilla gum in 2.5%, 5%, 7.5% doses, are effective enough to treat the symptoms of chapped skin disease, of which 5% bletilla glue effect is the best.
引文
[1]刘冷,孟宏,申亚丽等.紫精膏治疗皮肤皲裂疗效观察[J].现代中西医结合杂志,2014,23(6):634-635.
[2]韩冬梅,刘方波.赛肤润在皮肤皲裂患者中的应用[J].中国实用医药,2017,12(32):140-141.
[3]徐孝琦,徐孝玮.用硅油乳膏治疗皮肤皲裂症的疗效评析[J].当代医药论丛,2017,15(9):115-116.
[4]汪志铮.手足皲裂的防治方法[J].农家致富顾问,2017,(1):39.
[5]周继刚,付婷婷,温涛等.李时珍治皮肤病之皮肤皲裂症方药初探[J].时珍国医国药,2018,29(1):226.
[6]杨素清,张瀚月.白芨在常见皮肤疾病外治法中的应用[J].中医临床研究,2014,6(10):33-35.
[7]赵永伟,王艳宏.白及多糖的研究进展[J].中国中医药科技2015,22(4):479-481.
[8]汤逸飞,阮川芬,应晨等.白及属植物化学成分与药理作用研究进展[J].中草药,2014,45(19):2864-2872.
[9]万大群,赵仁全,刘海,等.白及的成分、药理作用和临床应用研究进展[J].中国药业,2017,26(2):93-96.
[10]邵鸽,陈鹰,潘明杰.银杏叶提取物对大鼠背部皮肤皲裂模型的疗效观察.中国药师,2016,19(4):656-658.
[11]JianZuo,QinYin,Yu-WeiWang,etal.InhibitionofNF-κBpathwayinfibroblast-likesynoviocytesbyα-mangostinimplicatedinprotectiveeffectsonjointsinratssufferingfromadjuvant-inducedarthritis InternationalImmunopharmacology,2018,56:78-89.
[12]张卫明,马世宏,顾龚平等.白芨多糖胶皮肤毒理学安全性评价研究[J].中国野生植物资源,2003,22(5):59-61.
[2]韩冬梅,刘方波.赛肤润在皮肤皲裂患者中的应用[J].中国实用医药,2017,12(32):140-141.
[3]徐孝琦,徐孝玮.用硅油乳膏治疗皮肤皲裂症的疗效评析[J].当代医药论丛,2017,15(9):115-116.
[4]汪志铮.手足皲裂的防治方法[J].农家致富顾问,2017,(1):39.
[5]周继刚,付婷婷,温涛等.李时珍治皮肤病之皮肤皲裂症方药初探[J].时珍国医国药,2018,29(1):226.
[6]杨素清,张瀚月.白芨在常见皮肤疾病外治法中的应用[J].中医临床研究,2014,6(10):33-35.
[7]赵永伟,王艳宏.白及多糖的研究进展[J].中国中医药科技2015,22(4):479-481.
[8]汤逸飞,阮川芬,应晨等.白及属植物化学成分与药理作用研究进展[J].中草药,2014,45(19):2864-2872.
[9]万大群,赵仁全,刘海,等.白及的成分、药理作用和临床应用研究进展[J].中国药业,2017,26(2):93-96.
[10]邵鸽,陈鹰,潘明杰.银杏叶提取物对大鼠背部皮肤皲裂模型的疗效观察.中国药师,2016,19(4):656-658.
[11]JianZuo,QinYin,Yu-WeiWang,etal.InhibitionofNF-κBpathwayinfibroblast-likesynoviocytesbyα-mangostinimplicatedinprotectiveeffectsonjointsinratssufferingfromadjuvant-inducedarthritis InternationalImmunopharmacology,2018,56:78-89.
[12]张卫明,马世宏,顾龚平等.白芨多糖胶皮肤毒理学安全性评价研究[J].中国野生植物资源,2003,22(5):59-61.