右美托咪定对COPD患者撤机后镇痛镇静作用分析
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摘要
目的探析右美托咪定对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者撤机后镇痛镇静作用。方法选用2017年1月—2018年9月经本院收治的成功撤机(> 12 h)COPD患者160例,分为对照组与观察组。给予对照组咪达唑仑联用枸橼酸芬太尼;给予观察组右美托咪定。观察两组相关数据。结果观察组给药1h、3 h及5 h收缩压低于对照组,P <0.05;观察组镇痛镇静有效率为95.0%,与对照组的87.5%相比,差异无统计学意义,P> 0.05;观察组不良反应发生概率为60.00%,较之对照组的86.25%而言,显著更低。结论右美托咪定作用于成功撤机(> 12 h)COPD患者,镇痛镇静效果显著。
Objective To investigate the analgesic and sedative effects of dexmedetomidine on patients with chronic obstructive pulmonary disease(COPD) after weaning. Methods A total of 160 patients with COPD who have successfully withdrew(>12 h) from January 2017 to September 2018 were enrolled in the control group and the observation group. The control group was given midazolam in combination with fentanyl citrate; The observation group was given dexmedetomidine. The relevant data of the two groups was observed. Results The systolic blood pressure of the observation group was lower than that of the control group at 1 h, 3 h and 5 h, P < 0.05. The effective rate of analgesia sedation in the observation group was 95.0%, compared with the control group of 87.5%, the difference was not statistically significant, P > 0.05.The probability of adverse reactions in the observation group was 60.00%, which was significantly lower than that of the control group of 86.25%. Conclusion Dexmedetomidine is effective in patients with COPD who have successfully withdrew(>12 h). The analgesic effect is significant.
Objective To investigate the analgesic and sedative effects of dexmedetomidine on patients with chronic obstructive pulmonary disease(COPD) after weaning. Methods A total of 160 patients with COPD who have successfully withdrew(>12 h) from January 2017 to September 2018 were enrolled in the control group and the observation group. The control group was given midazolam in combination with fentanyl citrate; The observation group was given dexmedetomidine. The relevant data of the two groups was observed. Results The systolic blood pressure of the observation group was lower than that of the control group at 1 h, 3 h and 5 h, P < 0.05. The effective rate of analgesia sedation in the observation group was 95.0%, compared with the control group of 87.5%, the difference was not statistically significant, P > 0.05.The probability of adverse reactions in the observation group was 60.00%, which was significantly lower than that of the control group of 86.25%. Conclusion Dexmedetomidine is effective in patients with COPD who have successfully withdrew(>12 h). The analgesic effect is significant.
引文
[1]罗耀文,石伟.不同剂量右美托咪定在慢性阻塞性肺疾病患者机械通气中的应用及对肺功能的影响[J].中华肺部疾病杂志(电子版),2017,10(4):441-444.
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[3]张继如,董楠,钱红娣,等.右美托咪定改善合并中度慢性阻塞性肺疾病肺癌手术患者的肺氧合功能[J].中南大学学报(医学版),2017,42(3):271-276.
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[8]唐庆凯,邢金城,王海云,等.复合右美托咪定时梗阻性黄疸患者依托咪酯抑制气管插管反应的半数有效剂量[J].中华麻醉学杂志,2017,37(3):341-343.
[9]郭昆,张红英,彭四萍.每日唤醒与舒适化镇痛镇静两种方案在ICU机械通气患者中的应用比较[J].中华危重病急救医学,2018,30(10):950-952.
[10]王宏伟,李兰兰,李治松,等.盐酸氢吗啡酮联合右美托咪定对经皮肝动脉化疗栓塞术治疗患者的静脉自控镇痛效果[J].中华肿瘤杂志,2018,40(8):626-630.
[11]杨智斌,沈江涌,米克德,等.右美托咪定复合瑞芬太尼在烧伤重症监护病房中清醒非插管患者换药时的应用研究[J].中华烧伤杂志,2018,34(10):707-713.
[12]王丁森,高永梅.咪唑安定序贯盐酸右美托咪定对ICU机械通气患者镇静的临床研究[J].中国卫生标准管理,2018,9(2):80-82.
[13]查文华,王军,丁留成,等. ACE基因多态性对右美托咪定抑制高血压患者气管拔管反应的影响[J].中华麻醉学杂志,2018,38(3):312-315.
[2]程伟,赵宁,卢妮娜.右美托咪定在AECOPD机械通气中应用观察[J].长治医学院学报,2018,32(5):352-354.
[3]张继如,董楠,钱红娣,等.右美托咪定改善合并中度慢性阻塞性肺疾病肺癌手术患者的肺氧合功能[J].中南大学学报(医学版),2017,42(3):271-276.
[4]尹睿,田东惠,吴萌萌,等.右美托咪啶联合布托啡诺在慢性阻塞性肺疾病无创通气中的应用研究[J].滨州医学院学报,2018,41(3):177-179.
[5]梁一男,解雅英,于建设.右美托咪定对梗阻性黄疸大鼠肝损伤的影响[J].中华麻醉学杂志,2016,36(9):1072-1075.
[6]李晓燕,解雅英,于建设,等.右美托咪定对梗阻性黄疸大鼠肠黏膜损伤的影响[J].中华麻醉学杂志,2017,37(11):1311-1313.
[7]葛红梅.基于Riker镇静-躁动评分系统的护理干预在神经外科ICU躁动患者中的应用[J].齐鲁护理杂志,2015,21(22):40-41.
[8]唐庆凯,邢金城,王海云,等.复合右美托咪定时梗阻性黄疸患者依托咪酯抑制气管插管反应的半数有效剂量[J].中华麻醉学杂志,2017,37(3):341-343.
[9]郭昆,张红英,彭四萍.每日唤醒与舒适化镇痛镇静两种方案在ICU机械通气患者中的应用比较[J].中华危重病急救医学,2018,30(10):950-952.
[10]王宏伟,李兰兰,李治松,等.盐酸氢吗啡酮联合右美托咪定对经皮肝动脉化疗栓塞术治疗患者的静脉自控镇痛效果[J].中华肿瘤杂志,2018,40(8):626-630.
[11]杨智斌,沈江涌,米克德,等.右美托咪定复合瑞芬太尼在烧伤重症监护病房中清醒非插管患者换药时的应用研究[J].中华烧伤杂志,2018,34(10):707-713.
[12]王丁森,高永梅.咪唑安定序贯盐酸右美托咪定对ICU机械通气患者镇静的临床研究[J].中国卫生标准管理,2018,9(2):80-82.
[13]查文华,王军,丁留成,等. ACE基因多态性对右美托咪定抑制高血压患者气管拔管反应的影响[J].中华麻醉学杂志,2018,38(3):312-315.