一次性根管治疗对牙体牙髓病的干预效果及其对血清骨保护素和炎性因子水平的影响
|
摘要
目的探究一次性根管治疗牙体牙髓病的效果及对血清骨保护素及炎性因子水平的影响。方法选取广东省中山市小榄人民医院2016年1月至2017年7月期间诊治的100例牙体牙髓病患者为研究对象,完全随机分为对照组和观察组,各50例,对照组患者进行常规的多次根管治疗,观察组患者进行一次性根管治疗。分析2组临床治疗效果及治疗后的不良反应发生率,并分析2组治疗前后血清中骨保护素、破骨细胞分化因子(RANKL)及炎性因子水平的变化。结果观察组的总有效率明显高于对照组[94. 0%(47/50)比76. 0%(38/50)],不良反应发生率明显低于对照组[8. 0%(4/50)比24. 0%(12/50)],差异均有统计学意义(均P <0. 05)。对照组和观察组患者治疗后血清骨保护素相对表达水平均较治疗前明显升高[对照组:(0. 37±0. 08)比(0. 32±0. 04);观察组:(0. 44±0. 09)比(0. 32±0. 05)],RANKL、C反应蛋白、白细胞介素2、白细胞介素6相对表达水平均明显降低[对照组:(0. 40±0. 09)比(0. 48±0. 12)、(0. 39±0. 08)比(0. 43±0. 10)、(0. 34±0. 07)比(0. 40±0. 05)、(0. 46±0. 09)比(0. 52±0. 13);观察组:(0. 37±0. 07)比(0. 49±0. 09)、(0. 32±0. 06)比(0. 43±0. 09)、(0. 30±0. 05)比(0. 41±0. 09)、(0. 40±0. 08)比(0. 53±0. 11)],差异均有统计学意义(均P <0. 05),且观察组的上述指标较对照组变化更明显(均P <0. 05)。结论一次性根管治疗牙体牙髓病临床效果好而不良反应发生率低,可能与其调节患者血清骨保护素及炎性因子水平有关。
Objective To explore the effect of disposable root canal therapy on dental pulp disease and serum levels of osteoprotegerin and inflammatory factors. Methods One hundred patients with endodontic disease admitted to Xiaolan People' s Hospital of Zhongshan,Guangdong Province from January 2016 to July 2017 were randomly divided into observation group and control group,with 50 cases in each group. The control group had routine root canal therapy. The observation group had one-off root canal therapy. Clinical effect,adverse reactions,changes of serum osteoprotegerin,receptor activator of nuclear factor-kB ligand( RANKL) and inflammatory factors were analyzed. Results Total effective rate in the observation group was significantly higher than that in the control group[94. 0%( 47/50) vs 76. 0%( 38/50) ]( P < 0. 05). Adverse reaction rate in the observation group was significantly lower than that in the control group[8. 0%( 4/50) vs 24. 0%( 12/50) ]( P < 0. 05). After treatment,relative expression level of serum osteoprotegerin significantly increased in both groups[control group:( 0. 37 ± 0. 08) vs( 0. 32 ± 0. 04); observation group:( 0. 44 ± 0. 09) vs( 0. 32 ± 0. 05) ]( P < 0. 05); levels of serum RANKL,C-reactive protein,interleukin-2 and interleukin-6 significantly decreased in both groups[control group:( 0. 40 ± 0. 09) vs( 0. 48 ± 0. 12),( 0. 39 ± 0. 08) vs( 0. 43 ± 0. 10),( 0. 34 ± 0. 07) vs( 0. 40 ±0. 05),( 0. 46 ± 0. 09) vs( 0. 52 ± 0. 13); observation group:( 0. 37 ± 0. 07) vs( 0. 49 ± 0. 09),( 0. 32 ±0. 06) vs( 0. 43 ± 0. 09),( 0. 30 ± 0. 05) vs( 0. 41 ± 0. 09),( 0. 40 ± 0. 08) vs( 0. 53 ± 0. 11) ]( all P <0. 05); the changes were more significant in the observation group( all P < 0. 05). Conclusion Disposable root canal therapy has good clinical effect on endodontics with low adverse reactions,which may be related to the regulation of serum osteoprotegerin and inflammatory factors.
Objective To explore the effect of disposable root canal therapy on dental pulp disease and serum levels of osteoprotegerin and inflammatory factors. Methods One hundred patients with endodontic disease admitted to Xiaolan People' s Hospital of Zhongshan,Guangdong Province from January 2016 to July 2017 were randomly divided into observation group and control group,with 50 cases in each group. The control group had routine root canal therapy. The observation group had one-off root canal therapy. Clinical effect,adverse reactions,changes of serum osteoprotegerin,receptor activator of nuclear factor-kB ligand( RANKL) and inflammatory factors were analyzed. Results Total effective rate in the observation group was significantly higher than that in the control group[94. 0%( 47/50) vs 76. 0%( 38/50) ]( P < 0. 05). Adverse reaction rate in the observation group was significantly lower than that in the control group[8. 0%( 4/50) vs 24. 0%( 12/50) ]( P < 0. 05). After treatment,relative expression level of serum osteoprotegerin significantly increased in both groups[control group:( 0. 37 ± 0. 08) vs( 0. 32 ± 0. 04); observation group:( 0. 44 ± 0. 09) vs( 0. 32 ± 0. 05) ]( P < 0. 05); levels of serum RANKL,C-reactive protein,interleukin-2 and interleukin-6 significantly decreased in both groups[control group:( 0. 40 ± 0. 09) vs( 0. 48 ± 0. 12),( 0. 39 ± 0. 08) vs( 0. 43 ± 0. 10),( 0. 34 ± 0. 07) vs( 0. 40 ±0. 05),( 0. 46 ± 0. 09) vs( 0. 52 ± 0. 13); observation group:( 0. 37 ± 0. 07) vs( 0. 49 ± 0. 09),( 0. 32 ±0. 06) vs( 0. 43 ± 0. 09),( 0. 30 ± 0. 05) vs( 0. 41 ± 0. 09),( 0. 40 ± 0. 08) vs( 0. 53 ± 0. 11) ]( all P <0. 05); the changes were more significant in the observation group( all P < 0. 05). Conclusion Disposable root canal therapy has good clinical effect on endodontics with low adverse reactions,which may be related to the regulation of serum osteoprotegerin and inflammatory factors.
引文
[1]李志斌.单次与重复多次根管预备充填治疗对牙体牙髓病效果分析[J].全科口腔医学杂志:电子版,2018,5(23):47-48.DOI:10. 3969/j. issn. 2095-7882. 2018. 23. 023.Li ZB. Effects of single and repeated root canal preparation and filling on dental pulp disease[J]. The Department of Oral Medicine Electronic Magazine(Electronic Edition),2018,5(23):47-48.DOI:10. 3969/j. issn. 2095-7882. 2018. 23. 023.
[2]李晓丽,董坚.牙隐裂伴牙髓炎患者根管治疗后全瓷冠修复和金属烤瓷冠修复的效果比较[J].中国医药,2018,13(9):1413-1416. DOI:10. 3760/j. issn. 1673-4777. 2018. 09. 033.Li XL,Dong J. Effects of all-ceramic crown and metal-ceramic crown after root canal therapy on cracked-teeth with pulpitis[J].China Medicine,2018,13(9):1413-1416. DOI:10. 3760/j.issn. 1673-4777. 2018. 09. 033.
[3]王娉婷,周盼,郑国莹,等.吡咯烷二硫氨基甲酸干预脂多糖刺激下牙周膜干细胞RANKL和OPG的表达[J].中国组织工程研究,2018,22(21):3365-3370. DOI:10. 3969/j. issn. 2095-4344. 0901.Wang PT,Zhou P,Zheng GY,et al. ntervention with pyrrolidine dithioearbamate stimulates expression of RANKL and OPG in lipopolysaccharide-stimulated periodontal ligament stem cells[J].Chinese Journal of Tissue Engineering Research,2018,22(21):3365-3370. DOI:10. 3969/j. issn. 2095-4344. 0901.
[4]刘梦余,叶玲,汪成林.白细胞介素-17及其在口腔疾病中的作用[J].国际口腔医学杂志,2015,42(6):728-732. DOI:10.7518/gjkq. 2015. 06. 026.Liu MY,Ye L,Wang CL. Interleukin-17 and its role in the oral diseases[J]. International Journal of Stomatology,2015,42(6):728-732. DOI:10. 7518/gjkq. 2015. 06. 026.
[5]孙万华.口腔科诊疗手册[M].北京:金盾出版社,2005:221-222.Sun WH. New dental clinic manual[M]. Beijing:Golden Shield Press,2005:221-222.
[6]张勇哲,王多诚,万莉,等.慢性根尖周炎一次性根管治疗的临床疗效分析[J].中国医刊,2017,52(9):88-91. DOI:10.3969/j. issn. 1008-1070. 2017. 09. 023.Zhang YZ,Wang DC,Wan L,et al. Clinical analysis of one-visit root canal therapy for chronic apical periodontitis[J]. Chinese Journal of Medicine,2017,52(9):88-91. DOI:10. 3969/j. issn.1008-1070. 2017. 09. 023.
[7]赵宏宠,刘婷,刘文曙.急性牙髓炎一次性根管与多次根管治疗的效果比较[J].中国医刊,2015,50(2):102-104. DOI:10.3969/j. issn. 1008-1070. 2015. 02. 030.Zhao HC,Liu T,Liu WS. Comparison of one-time root canal therapy and multiple root canal therapy for acute pulpitis[J]. Chinese Journal of Medicine,2015,50(2):102-104. DOI:10. 3969/j. issn. 1008-1070.2015. 02. 030.
[8]刘长庚,赵殿才,程自力,等.正畸对牙周膜细胞OPG、RANKL表达的影响[J].临床口腔医学杂志,2018,34(3):138-140.DOI:10. 3969/j. issn. 1003-1634. 2018. 03. 003.Liu CG,Zhao DC,Cheng ZL,et al. The effects of orthodontic force on the expression of OPG and RANKL in human periodontal ligament cells during orthodontic tooth movement[J]. Journal of Clinical Stomatology,2018,34(3):138-140. DOI:10. 3969/j.issn. 1003-1634. 2018. 03. 003.
[9]丁欣欣,李淑慧,葛翘诚,等.转化生长因子β1对牙周膜干细胞OPG/RANKL基因表达的影响[J].中华实用诊断与治疗杂志,2017,31(12):1156-1159. DOI:10. 13507/j. issn. 1674-3474. 2017. 12. 004.Ding XX,Li SH,Ge QC,et al. Influence of transforming growth factorβ1 on the expression of OPG/RANKL in human periodontal ligament stem cells[J]. Journal of Chinese Practical Diagnosis and Therapy,2017,31(12):1156-1159. DOI:10. 13507/j. issn.1674-3474. 2017. 12. 004.
[10]钟雯怡,杨琨,高丽,等. OPG、RANKL在2型糖尿病伴牙周炎大鼠牙槽骨中的表达[J].实用口腔医学杂志,2017,33(5):607-611. DOI:10. 3969/j. issn. 1001-3733. 2017. 05. 008.Zhong WY,Yang K,Gao L,et al. OPG and RANKL expression in alveolar bone of type 2 diabetic rats with periodontitis[J]. Journal of Practical Stomatology,2017,33(5):607-611. DOI:10. 3969/j.issn. 1001-3733. 2017. 05. 008.
[11]张勋.阿莫西林联用甲硝唑辅助牙周机械治疗对牙周炎患者龈沟液中病原菌及RANKL/OPG水平的影响[J].临床口腔医学杂志,2017,33(7):410-414. DOI:10. 3969/j. issn. 1003-1634. 2017. 07. 009.Zhang X. Effect of amoxicillin and metronidazole combined with mechanical therapy in the treatment of periodontitis and the influence on pathogenic bacteria and RANKL/OPG level[J]. 2017,33(7):410-414. DOI:10. 3969/j. issn. 1003-1634. 2017. 07. 009.
[12]赵秋怡,陶思雨,郭竹玲. RANKL/RANK/OPG通路在牙周病进程中的免疫机制研究[J].全科口腔医学电子杂志,2018,5(24):39-40. DOI:10. 3969/j. issn. 2095-7882. 2018. 24. 021.Zhao QY,Tao SY,Guo ZL. Study on the immune mechanism of RANKL/RANK/OPG pathway in periodontal disease[J]. The Department of Oral Medicine Electronic Magazine(Electronic Edition),2018,5(24):39-40. DOI:10. 3969/j. issn. 2095-7882. 2018. 24. 021.
[13]陈凯瑞,罗春媛,裴婧,等. RANK/RANKL/OPG在角化囊性瘤、含牙囊肿、单囊型成釉细胞瘤囊壁上皮层表达的比较[J].实用医学杂志,2018,34(17):2835-2838,2843. DOI:10. 3969/j.issn. 1006-5725. 2018. 17. 005.Chen KR, Luo CY, Pei J, et al. Comparative expression of RANK/RANKL/OPG in the epithelium lining of dentigerous cysts,keratocystic odontogenic tumors and unicystic ameloblastomas[J].The Journal of Practical Medicine,2018,34(17):2835-2838,2843. DOI:10. 3969/j. issn. 1006-5725. 2018. 17. 005.
[14]李春年.厚朴酚对大鼠实验性牙周炎骨吸收抑制作用的研究[J].实用口腔医学杂志,2018,34(3):341-345. DOI:10.3969/j. issn. 1001-3733. 2018. 03. 011.Li CN. Inhibitory effect of magnolol on alveolar bone resorption in rats with experimental periodontitis[J]. Journal of Practical Stomatology,2018,34(3):341-345. DOI:10. 3969/j. issn. 1001-3733. 2018. 03. 011.
[15]倪雪岩,吕亚林,曹莹,等.直观教学法在非口腔医学专业医学生牙体牙髓病教学中的设计与应用[J].中国医药,2014,9(9):1362-1366. DOI:10. 3760/cma. j. issn. 1673-4777. 2014. 09. 034.Ni XY,Lyu YL,Cao Y,et al. Application and design of audiovisual aids in stomatology teaching cariology,endodontology and operative dentistry in non-stomatology students[J]. China Medicine,2014,9(9):1362-1366. DOI:10. 3760/cma. j. issn. 1673-4777.2014. 09. 034.
[16]张丹丹,谢玉兰,许晓虎.二氧化锆修复体对患者咀嚼能力龈沟液中白细胞介素-6和白细胞介素-8水平的影响[J].山西医药杂志,2018,47(9):1029-1031. DOI:10. 3969/j. issn. 0253-9926. 2018. 09. 022.Zhang DD,Xie YL,Xu XH. Effect of zirconium dioxide prosthesis on masticatory capacity,levels of interleukin-6 and interleukin-8 in gingival crevicular fluid[J]. Shanxi Medical Journal,2018,47(9):1029-1031. DOI:10. 3969/j. issn. 0253-9926. 2018. 09. 022.
[17]臧运华.盐酸米诺环素缓释剂联合Vitapex治疗老年慢性牙周炎合并牙髓病变的疗效[J].中国老年学杂志,2018,38(1):191-193. DOI:10. 3969/j. issn. 1005-9202. 2018. 01. 081.Zang YH. Efficacy of minocycline hydrochloride combined with Vitapex in treating senile chronic periodontal-endodontic combined lesions[J]. Chinese Journal of Gerontology,2018,38(1):191-193. DOI:10. 3969/j. issn. 1005-9202. 2018. 01. 081.
[18]曲柳,于雅琼,仇丽鸿,等.牙髓卟啉单胞菌脂多糖诱导小鼠成骨细胞表达白细胞介素-2[J].实用口腔医学杂志,2016,32(4):453-456. DOI:10. 3969/j. issn. 1001-3733. 2016. 04. 001.Qu L, Yu YQ, Qiu LH, et al. Porhyromonas endodontalis liopolysaccharide regulates interleukin-23 expression in mouse osteoblasts[J]. Journal of Practical Stomatology,2016,32(4):453-456. DOI:10. 3969/j. issn. 1001-3733. 2016. 04. 001.
[2]李晓丽,董坚.牙隐裂伴牙髓炎患者根管治疗后全瓷冠修复和金属烤瓷冠修复的效果比较[J].中国医药,2018,13(9):1413-1416. DOI:10. 3760/j. issn. 1673-4777. 2018. 09. 033.Li XL,Dong J. Effects of all-ceramic crown and metal-ceramic crown after root canal therapy on cracked-teeth with pulpitis[J].China Medicine,2018,13(9):1413-1416. DOI:10. 3760/j.issn. 1673-4777. 2018. 09. 033.
[3]王娉婷,周盼,郑国莹,等.吡咯烷二硫氨基甲酸干预脂多糖刺激下牙周膜干细胞RANKL和OPG的表达[J].中国组织工程研究,2018,22(21):3365-3370. DOI:10. 3969/j. issn. 2095-4344. 0901.Wang PT,Zhou P,Zheng GY,et al. ntervention with pyrrolidine dithioearbamate stimulates expression of RANKL and OPG in lipopolysaccharide-stimulated periodontal ligament stem cells[J].Chinese Journal of Tissue Engineering Research,2018,22(21):3365-3370. DOI:10. 3969/j. issn. 2095-4344. 0901.
[4]刘梦余,叶玲,汪成林.白细胞介素-17及其在口腔疾病中的作用[J].国际口腔医学杂志,2015,42(6):728-732. DOI:10.7518/gjkq. 2015. 06. 026.Liu MY,Ye L,Wang CL. Interleukin-17 and its role in the oral diseases[J]. International Journal of Stomatology,2015,42(6):728-732. DOI:10. 7518/gjkq. 2015. 06. 026.
[5]孙万华.口腔科诊疗手册[M].北京:金盾出版社,2005:221-222.Sun WH. New dental clinic manual[M]. Beijing:Golden Shield Press,2005:221-222.
[6]张勇哲,王多诚,万莉,等.慢性根尖周炎一次性根管治疗的临床疗效分析[J].中国医刊,2017,52(9):88-91. DOI:10.3969/j. issn. 1008-1070. 2017. 09. 023.Zhang YZ,Wang DC,Wan L,et al. Clinical analysis of one-visit root canal therapy for chronic apical periodontitis[J]. Chinese Journal of Medicine,2017,52(9):88-91. DOI:10. 3969/j. issn.1008-1070. 2017. 09. 023.
[7]赵宏宠,刘婷,刘文曙.急性牙髓炎一次性根管与多次根管治疗的效果比较[J].中国医刊,2015,50(2):102-104. DOI:10.3969/j. issn. 1008-1070. 2015. 02. 030.Zhao HC,Liu T,Liu WS. Comparison of one-time root canal therapy and multiple root canal therapy for acute pulpitis[J]. Chinese Journal of Medicine,2015,50(2):102-104. DOI:10. 3969/j. issn. 1008-1070.2015. 02. 030.
[8]刘长庚,赵殿才,程自力,等.正畸对牙周膜细胞OPG、RANKL表达的影响[J].临床口腔医学杂志,2018,34(3):138-140.DOI:10. 3969/j. issn. 1003-1634. 2018. 03. 003.Liu CG,Zhao DC,Cheng ZL,et al. The effects of orthodontic force on the expression of OPG and RANKL in human periodontal ligament cells during orthodontic tooth movement[J]. Journal of Clinical Stomatology,2018,34(3):138-140. DOI:10. 3969/j.issn. 1003-1634. 2018. 03. 003.
[9]丁欣欣,李淑慧,葛翘诚,等.转化生长因子β1对牙周膜干细胞OPG/RANKL基因表达的影响[J].中华实用诊断与治疗杂志,2017,31(12):1156-1159. DOI:10. 13507/j. issn. 1674-3474. 2017. 12. 004.Ding XX,Li SH,Ge QC,et al. Influence of transforming growth factorβ1 on the expression of OPG/RANKL in human periodontal ligament stem cells[J]. Journal of Chinese Practical Diagnosis and Therapy,2017,31(12):1156-1159. DOI:10. 13507/j. issn.1674-3474. 2017. 12. 004.
[10]钟雯怡,杨琨,高丽,等. OPG、RANKL在2型糖尿病伴牙周炎大鼠牙槽骨中的表达[J].实用口腔医学杂志,2017,33(5):607-611. DOI:10. 3969/j. issn. 1001-3733. 2017. 05. 008.Zhong WY,Yang K,Gao L,et al. OPG and RANKL expression in alveolar bone of type 2 diabetic rats with periodontitis[J]. Journal of Practical Stomatology,2017,33(5):607-611. DOI:10. 3969/j.issn. 1001-3733. 2017. 05. 008.
[11]张勋.阿莫西林联用甲硝唑辅助牙周机械治疗对牙周炎患者龈沟液中病原菌及RANKL/OPG水平的影响[J].临床口腔医学杂志,2017,33(7):410-414. DOI:10. 3969/j. issn. 1003-1634. 2017. 07. 009.Zhang X. Effect of amoxicillin and metronidazole combined with mechanical therapy in the treatment of periodontitis and the influence on pathogenic bacteria and RANKL/OPG level[J]. 2017,33(7):410-414. DOI:10. 3969/j. issn. 1003-1634. 2017. 07. 009.
[12]赵秋怡,陶思雨,郭竹玲. RANKL/RANK/OPG通路在牙周病进程中的免疫机制研究[J].全科口腔医学电子杂志,2018,5(24):39-40. DOI:10. 3969/j. issn. 2095-7882. 2018. 24. 021.Zhao QY,Tao SY,Guo ZL. Study on the immune mechanism of RANKL/RANK/OPG pathway in periodontal disease[J]. The Department of Oral Medicine Electronic Magazine(Electronic Edition),2018,5(24):39-40. DOI:10. 3969/j. issn. 2095-7882. 2018. 24. 021.
[13]陈凯瑞,罗春媛,裴婧,等. RANK/RANKL/OPG在角化囊性瘤、含牙囊肿、单囊型成釉细胞瘤囊壁上皮层表达的比较[J].实用医学杂志,2018,34(17):2835-2838,2843. DOI:10. 3969/j.issn. 1006-5725. 2018. 17. 005.Chen KR, Luo CY, Pei J, et al. Comparative expression of RANK/RANKL/OPG in the epithelium lining of dentigerous cysts,keratocystic odontogenic tumors and unicystic ameloblastomas[J].The Journal of Practical Medicine,2018,34(17):2835-2838,2843. DOI:10. 3969/j. issn. 1006-5725. 2018. 17. 005.
[14]李春年.厚朴酚对大鼠实验性牙周炎骨吸收抑制作用的研究[J].实用口腔医学杂志,2018,34(3):341-345. DOI:10.3969/j. issn. 1001-3733. 2018. 03. 011.Li CN. Inhibitory effect of magnolol on alveolar bone resorption in rats with experimental periodontitis[J]. Journal of Practical Stomatology,2018,34(3):341-345. DOI:10. 3969/j. issn. 1001-3733. 2018. 03. 011.
[15]倪雪岩,吕亚林,曹莹,等.直观教学法在非口腔医学专业医学生牙体牙髓病教学中的设计与应用[J].中国医药,2014,9(9):1362-1366. DOI:10. 3760/cma. j. issn. 1673-4777. 2014. 09. 034.Ni XY,Lyu YL,Cao Y,et al. Application and design of audiovisual aids in stomatology teaching cariology,endodontology and operative dentistry in non-stomatology students[J]. China Medicine,2014,9(9):1362-1366. DOI:10. 3760/cma. j. issn. 1673-4777.2014. 09. 034.
[16]张丹丹,谢玉兰,许晓虎.二氧化锆修复体对患者咀嚼能力龈沟液中白细胞介素-6和白细胞介素-8水平的影响[J].山西医药杂志,2018,47(9):1029-1031. DOI:10. 3969/j. issn. 0253-9926. 2018. 09. 022.Zhang DD,Xie YL,Xu XH. Effect of zirconium dioxide prosthesis on masticatory capacity,levels of interleukin-6 and interleukin-8 in gingival crevicular fluid[J]. Shanxi Medical Journal,2018,47(9):1029-1031. DOI:10. 3969/j. issn. 0253-9926. 2018. 09. 022.
[17]臧运华.盐酸米诺环素缓释剂联合Vitapex治疗老年慢性牙周炎合并牙髓病变的疗效[J].中国老年学杂志,2018,38(1):191-193. DOI:10. 3969/j. issn. 1005-9202. 2018. 01. 081.Zang YH. Efficacy of minocycline hydrochloride combined with Vitapex in treating senile chronic periodontal-endodontic combined lesions[J]. Chinese Journal of Gerontology,2018,38(1):191-193. DOI:10. 3969/j. issn. 1005-9202. 2018. 01. 081.
[18]曲柳,于雅琼,仇丽鸿,等.牙髓卟啉单胞菌脂多糖诱导小鼠成骨细胞表达白细胞介素-2[J].实用口腔医学杂志,2016,32(4):453-456. DOI:10. 3969/j. issn. 1001-3733. 2016. 04. 001.Qu L, Yu YQ, Qiu LH, et al. Porhyromonas endodontalis liopolysaccharide regulates interleukin-23 expression in mouse osteoblasts[J]. Journal of Practical Stomatology,2016,32(4):453-456. DOI:10. 3969/j. issn. 1001-3733. 2016. 04. 001.