人类乳头状病毒(HPV)检测对宫颈癌前病变的预测价值分析
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摘要
目的综合分析人类乳头状病毒(HPV)检测对宫颈癌前病变的预测价值,为治疗宫颈癌前病变患者提供科学的数据参考。方法研究资料为方便选取2015年10月—2016年6月该院收治的宫颈癌前病变患者98例为研究对象,经患者同意,伦理委员会批准,按照检测方法的不同,分为实验组与对照组,每组49例。对照组应用传统宫颈细胞学检测方法,实验组应用HPV检测方法。采用SPSS 20.0统计学软件进行统计学分析两组患者的特异度以及灵敏度。结果病理学检查结果显示实验组中有15例阳性患者、34例阴性患者,实验组灵敏度、特异度分别为93.33%(14/15)、91.18%(31/34);对照组灵敏度、特异度分别为73.33%(11/15)、73.53%(25/34),实验组灵敏度与特异度均远远高于对照组(P<0.05)。结论 HPV检测对宫颈癌前病变的预测价值比较高。
Objective To comprehensively analyze the predictive value of HPV test for precancerous lesions of uterine cervix thus providing scientific reference for treating the patients with precancerous lesions of uterine cervix. Methods Convenient selection 98 cases of patients with precancerous lesions of uterine cervix admitted and treated in our hospital from October 2015 to June 2016 were selected as the research objects and divided into two groups with the content of patients according to different test methods with 49 cases in each, the control group adopted the traditional cervical cytology method,while the experimental group adopted the HPV test method, and the specificity and sensitivity of patients were statistically analyzed by the SPSS 20.0 statistical software. Results The pathology examination results showed that there were 15 cases of positive patients and 34 negative patients in the experimental group, and the sensitivity and specificity were respectively93.33%(14/15) and 91.18%(31/34) in the experimental group and 73.33%(11/15) and 73.53%(25/34) in the control group,and the sensitively and specificity in the experimental group were much higher than those in the control group(P <0.05).Conclusion The predictive value of HPV test for precancerous lesions of uterine cervix is higher.
Objective To comprehensively analyze the predictive value of HPV test for precancerous lesions of uterine cervix thus providing scientific reference for treating the patients with precancerous lesions of uterine cervix. Methods Convenient selection 98 cases of patients with precancerous lesions of uterine cervix admitted and treated in our hospital from October 2015 to June 2016 were selected as the research objects and divided into two groups with the content of patients according to different test methods with 49 cases in each, the control group adopted the traditional cervical cytology method,while the experimental group adopted the HPV test method, and the specificity and sensitivity of patients were statistically analyzed by the SPSS 20.0 statistical software. Results The pathology examination results showed that there were 15 cases of positive patients and 34 negative patients in the experimental group, and the sensitivity and specificity were respectively93.33%(14/15) and 91.18%(31/34) in the experimental group and 73.33%(11/15) and 73.53%(25/34) in the control group,and the sensitively and specificity in the experimental group were much higher than those in the control group(P <0.05).Conclusion The predictive value of HPV test for precancerous lesions of uterine cervix is higher.
引文
[1]徐志开.人类乳头状病毒(HPV)检测对宫颈癌前病变的预测价值分析[J].广东微量元素科学,2016,23(1):45-47.
[2]李克敏,尹如铁,康德英,等.人类乳头状病毒检测诊断宫颈癌前病变的价值:随机对照研究的系统评价[J].中国循证医学杂志,2011,11(8):910-918.
[3]刘志红,邹艳芬.宫颈液基细胞学检查与高危型HPV检测早期筛查宫颈癌前病变的对比分析[J].现代肿瘤医学,2016,24(8):1269-1271.
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[6]劳芝英.HPV、TCT及阴道镜对宫颈癌筛查的意义[J].实用癌症杂志,2014,15(7):826-828,831.
[7]曾新,韩一栩,吴丽香,等.HPV在宫颈炎、宫颈癌前病变、宫颈癌中的检测意义分析[J].中国实验诊断学,2014,18(1):127-128.
[8]陆洁清.TCT联合HPV检测在宫颈癌前病变诊断中的价值[J].实用癌症杂志,2013,28(5):550-552.
[9]黄美雯,程兰君,陈春丽,等.HPV、TCT检查联合阴道镜下活检用于宫颈癌筛查的临床价值[J]中外医疗,2014(8):15-16.
[10]李岚,苏莹,于燕,等.HPV检测作为宫颈癌前病变首筛项目的应用价值[J].中国妇幼保健,2015,30(34):6153-6154.
[11]吴丹梅,陈曼玲,金松,等.TCT HPV及h TERC基因检测在宫颈癌筛查中的临床价值[J].重庆医学,2013,42(34):4185-4187.
[2]李克敏,尹如铁,康德英,等.人类乳头状病毒检测诊断宫颈癌前病变的价值:随机对照研究的系统评价[J].中国循证医学杂志,2011,11(8):910-918.
[3]刘志红,邹艳芬.宫颈液基细胞学检查与高危型HPV检测早期筛查宫颈癌前病变的对比分析[J].现代肿瘤医学,2016,24(8):1269-1271.
[4]魏文斐,苏桂栋,吴兰芳,等.宫颈癌与癌前病变组织中HPV-16的整合感染状态[J].南方医科大学学报,2015,12(1):47-50.
[5]李云.液基细胞学联合HPV基因分型检测在宫颈癌前病变筛查中的应用探讨[J].中外医疗,2015(7):8-9.
[6]劳芝英.HPV、TCT及阴道镜对宫颈癌筛查的意义[J].实用癌症杂志,2014,15(7):826-828,831.
[7]曾新,韩一栩,吴丽香,等.HPV在宫颈炎、宫颈癌前病变、宫颈癌中的检测意义分析[J].中国实验诊断学,2014,18(1):127-128.
[8]陆洁清.TCT联合HPV检测在宫颈癌前病变诊断中的价值[J].实用癌症杂志,2013,28(5):550-552.
[9]黄美雯,程兰君,陈春丽,等.HPV、TCT检查联合阴道镜下活检用于宫颈癌筛查的临床价值[J]中外医疗,2014(8):15-16.
[10]李岚,苏莹,于燕,等.HPV检测作为宫颈癌前病变首筛项目的应用价值[J].中国妇幼保健,2015,30(34):6153-6154.
[11]吴丹梅,陈曼玲,金松,等.TCT HPV及h TERC基因检测在宫颈癌筛查中的临床价值[J].重庆医学,2013,42(34):4185-4187.