从中医脏腑经络学说论肠道菌群
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摘要
肠道菌群被称为机体中"被遗忘的器官"。而近年来大量的研究表明这一"被遗忘的器官"在人体中扮演着重要的角色。中医脏腑经络学说是中医基础理论重要学说之一,其与肠道微生态有相似相通之处。脏腑经络互为表里,在病变上能够互相影响、互相传变,因此我们基于肺与大肠相表里、心与小肠相表里、脾胃为气血生化之源、魄门亦为五脏使、肾为胃之关等中医理论来探讨肠道菌群。
Intestinal flora is known as the"forgotten organ"in the body. In recent years,a large number of studies have shown that this"forgotten organ"plays an important role in the human body. The theory of TCM viscera and meridians theory is one of the important theories in the basic theory of traditional Chinese medicine. It has similarities with intestinal microecology. Viscera and meridians are exterior and interior to each other,and can influence each other in pathological changes. Therefore,we discuss the intestines based on the theories of lung and large intestine,heart and small intestine,spleen and stomach as the source of Qi and blood biochemistry,spiritual gate as the five organs and kidney as the key to stomach.
Intestinal flora is known as the"forgotten organ"in the body. In recent years,a large number of studies have shown that this"forgotten organ"plays an important role in the human body. The theory of TCM viscera and meridians theory is one of the important theories in the basic theory of traditional Chinese medicine. It has similarities with intestinal microecology. Viscera and meridians are exterior and interior to each other,and can influence each other in pathological changes. Therefore,we discuss the intestines based on the theories of lung and large intestine,heart and small intestine,spleen and stomach as the source of Qi and blood biochemistry,spiritual gate as the five organs and kidney as the key to stomach.
引文
[1]邵加庆.代谢性疾病防控的新大陆——肠道菌群[J].医学研究生报,2016(1):16-20.
[2]罗佳,金锋.肠道菌群影响宿主行为的研究进展[J].科学通报,2014(22):2169-2190.
[3]王生,黄晓星,余鹏飞,等.肠道菌群失调与结肠癌发生发展之间关系的研究进展[J].中国药理学通报,2014(8):1045-1049.
[4]莫芳芳.基于古代医案分析的“肺与大肠相表里”理论的应用研究[D].北京:北京中医药大学,2012.
[5]陈晓慧,李巍,鱼芳,等.肺癌患者铂类药物化疗后肠道菌群变化的临床研究[J].中国微生态学杂志,2016,28(7):781-785.
[6] Wakabayashi C,Hasegawa H,Murata J,et al. In vivo antimetastaticaction of ginseng protopanaxadiol saponins is based on their intestinal bacteri-al metabolites after oral administration[J].Oncol Res,1997,9(8):411-418.
[7]王榕.腹泻型肠易激综合征中医证型与小肠细菌过度生长及口—盲通过时间相关性研究[D].福州:福建中医药大学,2016.
[8]周英,刘卫东,孙必强,等.七味白术散及提取物对肠道菌群失调小鼠小肠黏膜上皮IFN-α,IL-4,IL-10表达的影响[J].中国实验方剂学杂志,2015,21(9):112-117.
[9]魏润杰.克罗恩病患者小肠黏膜内菌群的研究[D].济南:山东大学,2016.
[10]车轶文,于宁,翟双庆.脾与肠道菌群相关性的理论探析[J].世界中医药,2015,10(5):703-706.
[11]孔凡华,成泽东.肠道菌群失调的中医病机探讨[J].江西中医药大学学报,2016,28(6):6-7,13.
[12]巩静,陈广,王定坤,等.从脾胃论治糖尿病与肠道菌群的关系[J].中国中西医结合杂志,2016,36(4):484-487.
[13]陈晓刚.小儿再发性腹痛的脾胃湿热证与肠道微生态关系的研究[D].广州:广州中医药大学,2007.
[14]樊均明,马欣,文集.肠道菌群的微生态改变与慢性肾脏疾病[J].中国中西医结合肾病杂志,2013,14(12):1035-1037.
[15] Aronov PA,Luo FJ,Plummer NS,et al. Colonic contribution touremic solutes[J].J Am Soc Nephrol,2011,22(8):1769-1776.
[16]袁伟杰,王玲.肠道微生态与肾脏疾病[J].肾脏病与透析肾移植杂志,2017,26(2):153-154.
[17]许倩倩,窦迎春,张燕,等.肠道菌群失调患者肛门直肠动力学的研究[J].中华临床医师杂志(电子版),2017,11(1):22-26.
[18]樊文娟,李斌,曹农.双歧杆菌三联活菌胶囊在术后早期炎性肠梗阻治疗中的应用[J].中国微生态学杂志,2017,29(5):543-546.
[19] Thalheimer U,De Iorio F,Capra F,et al. Altered intestinal func-tion precedes the appearance of bacterial DNA in serum and ascitesin patients with cirrhosis:a pilot study[J]. Eur J Gastroenterol Hepatol,2010,22(10):1228-1234.
[20] Gunnarsdottir S A,Sadik R,Shev S,et al. Small intestinal motilitydisturbances and bacterial overgrowth in patients with liver cirrho-sis and portal hypertension[J].Am J Gastroenterol,2003,98(6):1362-1370.
[21]吴绍德.脏腑经络学说的基本知识[J].上海中医药杂志,1986(3):26-27.
[22]靳冰.大肠经义四用探析[J].中医文献杂志,2000(3):17.
[23] Zackular JP,Baxter NT,Iverson KD,et al. The gut microbiome mod-ulates colon tumorigenesis[J]. mBio,2013,4(6):e00692.
[24]陈卫,田培郡,张程程,等.肠道菌群与人体健康的研究热点与进展[J].中国食品学报,2017,17(2):1-9.
[2]罗佳,金锋.肠道菌群影响宿主行为的研究进展[J].科学通报,2014(22):2169-2190.
[3]王生,黄晓星,余鹏飞,等.肠道菌群失调与结肠癌发生发展之间关系的研究进展[J].中国药理学通报,2014(8):1045-1049.
[4]莫芳芳.基于古代医案分析的“肺与大肠相表里”理论的应用研究[D].北京:北京中医药大学,2012.
[5]陈晓慧,李巍,鱼芳,等.肺癌患者铂类药物化疗后肠道菌群变化的临床研究[J].中国微生态学杂志,2016,28(7):781-785.
[6] Wakabayashi C,Hasegawa H,Murata J,et al. In vivo antimetastaticaction of ginseng protopanaxadiol saponins is based on their intestinal bacteri-al metabolites after oral administration[J].Oncol Res,1997,9(8):411-418.
[7]王榕.腹泻型肠易激综合征中医证型与小肠细菌过度生长及口—盲通过时间相关性研究[D].福州:福建中医药大学,2016.
[8]周英,刘卫东,孙必强,等.七味白术散及提取物对肠道菌群失调小鼠小肠黏膜上皮IFN-α,IL-4,IL-10表达的影响[J].中国实验方剂学杂志,2015,21(9):112-117.
[9]魏润杰.克罗恩病患者小肠黏膜内菌群的研究[D].济南:山东大学,2016.
[10]车轶文,于宁,翟双庆.脾与肠道菌群相关性的理论探析[J].世界中医药,2015,10(5):703-706.
[11]孔凡华,成泽东.肠道菌群失调的中医病机探讨[J].江西中医药大学学报,2016,28(6):6-7,13.
[12]巩静,陈广,王定坤,等.从脾胃论治糖尿病与肠道菌群的关系[J].中国中西医结合杂志,2016,36(4):484-487.
[13]陈晓刚.小儿再发性腹痛的脾胃湿热证与肠道微生态关系的研究[D].广州:广州中医药大学,2007.
[14]樊均明,马欣,文集.肠道菌群的微生态改变与慢性肾脏疾病[J].中国中西医结合肾病杂志,2013,14(12):1035-1037.
[15] Aronov PA,Luo FJ,Plummer NS,et al. Colonic contribution touremic solutes[J].J Am Soc Nephrol,2011,22(8):1769-1776.
[16]袁伟杰,王玲.肠道微生态与肾脏疾病[J].肾脏病与透析肾移植杂志,2017,26(2):153-154.
[17]许倩倩,窦迎春,张燕,等.肠道菌群失调患者肛门直肠动力学的研究[J].中华临床医师杂志(电子版),2017,11(1):22-26.
[18]樊文娟,李斌,曹农.双歧杆菌三联活菌胶囊在术后早期炎性肠梗阻治疗中的应用[J].中国微生态学杂志,2017,29(5):543-546.
[19] Thalheimer U,De Iorio F,Capra F,et al. Altered intestinal func-tion precedes the appearance of bacterial DNA in serum and ascitesin patients with cirrhosis:a pilot study[J]. Eur J Gastroenterol Hepatol,2010,22(10):1228-1234.
[20] Gunnarsdottir S A,Sadik R,Shev S,et al. Small intestinal motilitydisturbances and bacterial overgrowth in patients with liver cirrho-sis and portal hypertension[J].Am J Gastroenterol,2003,98(6):1362-1370.
[21]吴绍德.脏腑经络学说的基本知识[J].上海中医药杂志,1986(3):26-27.
[22]靳冰.大肠经义四用探析[J].中医文献杂志,2000(3):17.
[23] Zackular JP,Baxter NT,Iverson KD,et al. The gut microbiome mod-ulates colon tumorigenesis[J]. mBio,2013,4(6):e00692.
[24]陈卫,田培郡,张程程,等.肠道菌群与人体健康的研究热点与进展[J].中国食品学报,2017,17(2):1-9.