心脑宁胶囊联合丁咯地尔治疗脑供血不足性眩晕症的临床研究
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摘要
目的探讨心脑宁胶囊联合丁咯地尔治疗脑供血不足性眩晕症的临床疗效。方法选取2017年8月—2018年8月在天津市宝坻区人民医院治疗的脑供血不足性眩晕症患者86例,根据住院号分为对照组(43例)和治疗组(43例)。对照组口服盐酸丁咯地尔片,0.3g/次,2次/d;治疗组在对照组基础上口服心脑宁胶囊,3/粒,3次/d。两组患者均治疗4周。观察两组患者临床疗效,同时比较治疗前后两组患者眩晕评分、FS-CSA评分、脑多普勒超声(TCD)结果和血清学指标水平。结果治疗后,对照组临床有效率为81.40%,显著低于治疗组的97.67%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者眩晕评分显著升高(P<0.05),FS-CSA评分显著降低(P<0.05),且治疗组眩晕评分和FS-CSA评分明显好于对照组(P<0.05)。治疗后,两组椎动脉和基底动脉的平均血流速度(Vm)显著升高(P<0.05),椎动脉和基底动脉的脉动指数(PI)显著降低(P<0.05),且治疗组TCD结果明显好于对照组(P<0.05)。治疗后,两组患者血小板活化因子(PAF)、血栓素B2(TXB2)、白细胞介素-8(IL-8)水平显著降低(P<0.05),且治疗组PAF、TXB2、IL-8水平明显低于对照组(P<0.05)。结论心脑宁胶囊联合盐酸丁咯地尔片治疗脑供血不足性眩晕症可有效改善患者临床症状,改善血流动力学指标,降低血清PAF、TXB2、IL-8水平。
Objective To explore the clinical efficacy of Xinnaoning Capsules combined with buflomedil in treatment of cerebral insufficiency vertigo. Methods Patients(86 cases) with cerebral insufficiency vertigo in Tianjin Baodi hospital from August 2017 to August 2018 were divided into control(43 cases) and treatment(43 cases) groups based on different admission number. Patients in the control group were po administered with Buflomedil Hydrochloride Tablets, 0.3 g/time, twice daily. Patients in the treatment group were po administered with Xinnaoning Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the vertigo scores, FS-CSA scores, TCD results and serological indexes levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 81.40%, which was significantly lower than 97.67% in the treatment group, and there were differences between two groups(P < 0.05). After treatment, the vertigo scores in two groups were significantly increased(P < 0.05), but FS-CSA scores were significantly decreased(P < 0.05), and these scores in the treatment group were significantly better than those in the control group(P < 0.05). After treatment, the Vm of vertebral artery and basilar artery in two groups was significantly increased(P < 0.05), the PI of vertebral artery and basilar artery was significantly decreased(P < 0.05), and the TCD results in the treatment group was significantly better than that in the control group(P < 0.05). After treatment, the PAF, TXB2 and IL-8 levels in two groups were significantly decreased(P < 0.05), and which in the treatment group were significantly lower than those in the control group(P < 0.05). ConclusionXinnaoning Capsules combined with buflomedil in treatment of cerebral insufficiency vertigo can effectively improve the clinical symptoms, improve hemodynamic indicators, reduce serum levels of PAF, TXB2, IL-8.
Objective To explore the clinical efficacy of Xinnaoning Capsules combined with buflomedil in treatment of cerebral insufficiency vertigo. Methods Patients(86 cases) with cerebral insufficiency vertigo in Tianjin Baodi hospital from August 2017 to August 2018 were divided into control(43 cases) and treatment(43 cases) groups based on different admission number. Patients in the control group were po administered with Buflomedil Hydrochloride Tablets, 0.3 g/time, twice daily. Patients in the treatment group were po administered with Xinnaoning Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the vertigo scores, FS-CSA scores, TCD results and serological indexes levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 81.40%, which was significantly lower than 97.67% in the treatment group, and there were differences between two groups(P < 0.05). After treatment, the vertigo scores in two groups were significantly increased(P < 0.05), but FS-CSA scores were significantly decreased(P < 0.05), and these scores in the treatment group were significantly better than those in the control group(P < 0.05). After treatment, the Vm of vertebral artery and basilar artery in two groups was significantly increased(P < 0.05), the PI of vertebral artery and basilar artery was significantly decreased(P < 0.05), and the TCD results in the treatment group was significantly better than that in the control group(P < 0.05). After treatment, the PAF, TXB2 and IL-8 levels in two groups were significantly decreased(P < 0.05), and which in the treatment group were significantly lower than those in the control group(P < 0.05). ConclusionXinnaoning Capsules combined with buflomedil in treatment of cerebral insufficiency vertigo can effectively improve the clinical symptoms, improve hemodynamic indicators, reduce serum levels of PAF, TXB2, IL-8.
引文
[1]张素珍.眩晕症的诊断与治疗[M].第2版.北京:人民军医出版社, 2007:1.
[2]李永超,彭宝淦.颈性眩晕的发病机制及诊治新进展[J].中国矫形外科杂志, 2015, 23(3):250-253.
[3]赵东坤,张曰礼,邵传芳.丁咯地尔的药理与临床应用[J].上海医药, 2003, 24(5):219-220.
[4]安宇,何庆勇.心脑宁胶囊的组成药物的药理作用和临床应用[J].北京医学, 2015, 37(1):103-104.
[5]吴江,贾建平.神经病学[M].第3版,北京:人民卫生出版社, 2015:213-215.
[6]赵鑫,李中实.颈性眩晕的诊断及鉴别诊断[J].中日友好医院学报, 2016, 30(2):109-111.
[7]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社, 2002:99-104.
[8]王楚怀,卓大宏.颈性眩晕患者症状与功能评估的初步研究[J].中国康复医学杂志学, 1998, 13(6):245-247.
[9]魏毅,梁伟雄,蔡业峰.椎动脉型颈椎病功能评定量表(FS-CSA)的初步建立[J].中国康复医学杂志,2003, 18(7):410-412.
[10]刘博,孙建军.重视眩晕诊疗的规范化提升前庭疾病诊治水平[J].临床耳鼻咽喉头颈外科杂志, 2016,30(8):593-595.
[11]叶洁,顾小华,许金海,等.颈性眩晕的中医证型与脑血流动力学的相关性研究[J].中国中医骨伤杂志,2014, 22(3):7-10.
[12]张秀华,李光来.慢性脑供血不足的研究进展[J].中西医结合心脑血管病杂志, 2007, 5(3):249-251.
[13]袁奇,张小华乔延江.血小板活化因子及其受体拮抗剂的研究进展[J].中华中医药杂志, 2011, 26(7):1568-1571.
[14]董洪英,王秀云,孟向文,等.针刺对神经根型颈椎病血清血栓素B2影响与疗效的研究[J].中医药学刊,2003, 21(9):1428, 1459.
[15]姚瑶,王琳琳.白细胞介素-8研究进展[J].中华实用儿科临床杂志, 2009, 24(10):789-792.
[2]李永超,彭宝淦.颈性眩晕的发病机制及诊治新进展[J].中国矫形外科杂志, 2015, 23(3):250-253.
[3]赵东坤,张曰礼,邵传芳.丁咯地尔的药理与临床应用[J].上海医药, 2003, 24(5):219-220.
[4]安宇,何庆勇.心脑宁胶囊的组成药物的药理作用和临床应用[J].北京医学, 2015, 37(1):103-104.
[5]吴江,贾建平.神经病学[M].第3版,北京:人民卫生出版社, 2015:213-215.
[6]赵鑫,李中实.颈性眩晕的诊断及鉴别诊断[J].中日友好医院学报, 2016, 30(2):109-111.
[7]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社, 2002:99-104.
[8]王楚怀,卓大宏.颈性眩晕患者症状与功能评估的初步研究[J].中国康复医学杂志学, 1998, 13(6):245-247.
[9]魏毅,梁伟雄,蔡业峰.椎动脉型颈椎病功能评定量表(FS-CSA)的初步建立[J].中国康复医学杂志,2003, 18(7):410-412.
[10]刘博,孙建军.重视眩晕诊疗的规范化提升前庭疾病诊治水平[J].临床耳鼻咽喉头颈外科杂志, 2016,30(8):593-595.
[11]叶洁,顾小华,许金海,等.颈性眩晕的中医证型与脑血流动力学的相关性研究[J].中国中医骨伤杂志,2014, 22(3):7-10.
[12]张秀华,李光来.慢性脑供血不足的研究进展[J].中西医结合心脑血管病杂志, 2007, 5(3):249-251.
[13]袁奇,张小华乔延江.血小板活化因子及其受体拮抗剂的研究进展[J].中华中医药杂志, 2011, 26(7):1568-1571.
[14]董洪英,王秀云,孟向文,等.针刺对神经根型颈椎病血清血栓素B2影响与疗效的研究[J].中医药学刊,2003, 21(9):1428, 1459.
[15]姚瑶,王琳琳.白细胞介素-8研究进展[J].中华实用儿科临床杂志, 2009, 24(10):789-792.