新活素对难治性心衰患者血清超敏C反应蛋白及B型脑钠肽的影响分析
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摘要
目的难治性心力衰竭(心衰)患者使用冻干重组人脑利钠肽(商品名:新活素)对患者血清超敏C反应蛋白(hs-CRP)及B型脑钠肽(BNP)的影响。方法 80例难治性心衰患者,随机分为试验组和对照组,每组40例。对照组患者采用常规基础治疗,试验组患者在对照组的基础上采用新活素治疗。比较两组患者治疗前后hs-CRP和BNP水平。结果治疗后,两组患者hs-CRP、BNP水平均低于本组治疗前,且试验组患者hs-CRP(4.2±1.0)mg/L、BNP(1015.3±103.7)ng/L低于对照组的(9.8±1.6)mg/L、(1621.0±103.2)ng/L,差异具有统计学意义(P<0.05)。结论难治性心衰患者使用新活素进行治疗,可以明显改善患者血清hs-CRP及BNP值,提高临床效果,值得在临床推广。
Objective To discuss the effect of lyophilized recombinant human brain natriuretic peptide(trade name: neovaxin) on serum hypersensitive C-reactive protein(hs-CRP) and B-type brain natriuretic peptide(BNP) in patients with refractory heart failure. Methods A total of 80 patients with refractory heart failure were randomly divided into experimental group and control group, with 40 cases in each group. The control group received conventional basic therapy, and the experimental group received neovaxin on the basis of the control group. The hs-CRP and BNP level before and after treatment was compared. Results After treatment, both groups had lower hs-CRP and BNP than before treatment, and the experimental group had lower hs-CRP as(4.2±1.0) mg/L and BNP as(1015.3±103.7) ng/L than(9.8±1.6) mg/L and(1621.0 ±103.2) ng/L in the control group. Their difference was statistically significant(P<0.05). Conclusion Neovaxin can obviously improve the hs-CRP and BNP of patients with refractory heart failure and improve the clinical effect. It is worthy of clinical promotion.
Objective To discuss the effect of lyophilized recombinant human brain natriuretic peptide(trade name: neovaxin) on serum hypersensitive C-reactive protein(hs-CRP) and B-type brain natriuretic peptide(BNP) in patients with refractory heart failure. Methods A total of 80 patients with refractory heart failure were randomly divided into experimental group and control group, with 40 cases in each group. The control group received conventional basic therapy, and the experimental group received neovaxin on the basis of the control group. The hs-CRP and BNP level before and after treatment was compared. Results After treatment, both groups had lower hs-CRP and BNP than before treatment, and the experimental group had lower hs-CRP as(4.2±1.0) mg/L and BNP as(1015.3±103.7) ng/L than(9.8±1.6) mg/L and(1621.0 ±103.2) ng/L in the control group. Their difference was statistically significant(P<0.05). Conclusion Neovaxin can obviously improve the hs-CRP and BNP of patients with refractory heart failure and improve the clinical effect. It is worthy of clinical promotion.
引文
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[6]王文海,张文彬.硝普钠与新活素治疗难治性心衰对比分析.中国实用医药, 2017, 12(34):113-114.
[7]张惠芳,高小红,王凤霞,等.新活素用于难治性心力衰竭的临床评价及对血清TnT、NT-proBNP与CRP的影响.中西医结合心脑血管病杂志, 2017, 15(12):1432-1434.
[8]丁兵,宋建平.新活素治疗难治性心力衰竭的临床疗效观察.浙江临床医学, 2016, 18(12):2282-2283.
[2]姜敏华,敬波,于军,等.新活素对老年急性失代偿期心力衰竭患者心功能、尿量及精神状态的影响.国际精神病学杂志,2015, 42(3):55-57.
[3]于海杰,关启刚,李玉泽,等.新活素对心肌梗死泵功能衰竭患者心肌重构的影响研究.实用预防医学, 2013, 20(1):87-89.
[4]王鲁奇,许浩军,翟旭鹏,等.新活素对难治性心力衰竭患者血清高敏C反应蛋白及脑利钠肽的影响.临床合理用药杂志,2015, 8(34):78-79.
[5]金莉子,董杰,马英东.新活素治疗对充血性心力衰竭患者NT-proBNP及CRP的影响.中外医学研究, 2011, 9(28):18-19.
[6]王文海,张文彬.硝普钠与新活素治疗难治性心衰对比分析.中国实用医药, 2017, 12(34):113-114.
[7]张惠芳,高小红,王凤霞,等.新活素用于难治性心力衰竭的临床评价及对血清TnT、NT-proBNP与CRP的影响.中西医结合心脑血管病杂志, 2017, 15(12):1432-1434.
[8]丁兵,宋建平.新活素治疗难治性心力衰竭的临床疗效观察.浙江临床医学, 2016, 18(12):2282-2283.