丹蒌片联合阿司匹林治疗老年冠心病心绞痛疗效观察
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摘要
目的:探讨丹蒌片联合阿司匹林治疗老年冠心病心绞痛的临床疗效和安全性。方法:将66例老年冠心病心绞痛患者随机分为观察组和对照组,各33例。在常规西药治疗基础上,对照组给予阿司匹林口服,观察组给予阿司匹林联合丹蒌片口服,比较两组患者总体疗效,以及治疗前后心绞痛发作次数、持续时间、静息心电图结果、心功能各项指标的差异,并统计两组治疗期间发生的不良反应。结果:观察组治疗总有效率显著高于对照组(P<0.05);观察组治疗后心绞痛发作次数和心绞痛持续时间均显著小于对照组(P<0.01);观察组治疗后静息心电图ST段下移导联数显著少于对照组(P<0.01);观察组治疗后心功能各指标均显著优于对照组(P<0.05)。两组不良反应差异无统计学意义(P>0.05)。结论:丹蒌片联合阿司匹林治疗老年冠心病心绞痛的临床疗效确切,安全性好。
Objective: To investigate the clinical effect of Danlou Tablets combined with aspirin in treatment of senile angina of coronary heart disease. Methods: Sixty-six elderly patients with angina were randomly divided into observation group(n=33) and control group(n=33). Patients in the control group received aspirin on the basis of conventional treatment, while the ones in the treatment group received aspirin and Danlou Tablets. The overall curative effect, angina attacks frequency and duration, resting electrocardiogram and cardiac parameters between two groups were compared. Results: The total effective rate of observation group was significantly higher than that of control group(P<0.05). The angina attacks frequency and duration in observation group after treatment were significantly lower than that in control group(P<0.01). The numbers of ST segment depression in observation group after treatment were significantly less than those in the control group(P<0.01). The cardiac parameters in observation group after treatment were superior to those in the control group(P<0.05). Adverse effects had no significant difference between the two groups(P>0.05). Conclusion: Danlou Tablets combined with aspirin might have obvious curative effect and safety to treat senile angina of coronary heart disease.
Objective: To investigate the clinical effect of Danlou Tablets combined with aspirin in treatment of senile angina of coronary heart disease. Methods: Sixty-six elderly patients with angina were randomly divided into observation group(n=33) and control group(n=33). Patients in the control group received aspirin on the basis of conventional treatment, while the ones in the treatment group received aspirin and Danlou Tablets. The overall curative effect, angina attacks frequency and duration, resting electrocardiogram and cardiac parameters between two groups were compared. Results: The total effective rate of observation group was significantly higher than that of control group(P<0.05). The angina attacks frequency and duration in observation group after treatment were significantly lower than that in control group(P<0.01). The numbers of ST segment depression in observation group after treatment were significantly less than those in the control group(P<0.01). The cardiac parameters in observation group after treatment were superior to those in the control group(P<0.05). Adverse effects had no significant difference between the two groups(P>0.05). Conclusion: Danlou Tablets combined with aspirin might have obvious curative effect and safety to treat senile angina of coronary heart disease.
引文
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[10] 徐鹏智. 冠心病心绞痛内科治疗临床分析[J]. 中西医结合心血管病电子杂志, 2017, 5(29): 69.
[11] 唐梅森, 黄政德, 向忠军,等. 加味丹参饮联合西药治疗冠心病心绞痛心血瘀阻证68例疗效观察[J]. 中医杂志, 2015, 56(5):395-397.
[12] 黄永柱, 施泳光. 氯吡格雷联合阿司匹林治疗不稳定型心绞痛的效果与安全性[J]. 中国医药导报, 2016, 13(17):129-131.
[13] 蒲月英, 张万超, 何文富. 拜阿司匹林联合氯吡格雷及阿托伐他汀治疗不稳定性心绞痛疗效观察[J]. 西部医学, 2012, 24(1):94-95.
[14] 李小龙, 陆岩, 张琪. 氯吡格雷联合拜阿司匹林治疗稳定型心绞痛效果观察[J]. 山东医药, 2017, 57(42):64-66.
[15] 周芹. 益气活血法治疗老年冠心病心绞痛40例[J]. 河南中医, 2015, 35(9):2079-2081.
[16] 杨东辉. 中西医结合治疗冠心病心绞痛临床疗效观察[J]. 四川中医, 2015(5):67-69.
[17] 徐亚莉, 王曦, 张卫红. 丹蒌片治疗慢性稳定性劳累心绞痛患者的疗效观察[J]. 陕西中医, 2015(7):890-890.
[18] 路晶晶, 雷翔, 商洪才. 丹蒌片治疗痰瘀互阻型稳定型心绞痛的系统评价[J]. 中西医结合心脑血管病杂志, 2017, 15(10):1198-1202.
[19] 郭伟民. 丹蒌片治疗高龄冠心病患者介入支架植入术后心绞痛的疗效观察[J]. 河南医学研究, 2016, 25(7):1282-1283.
[20] 古丽莎, 马志萍. 丹蒌片联合西药治疗冠心病心绞痛的疗效及对血清炎性因子的影响[J]. 中国保健营养, 2017, 27(2): 111.
[2] Xu X, Zhang W, Zhou Y, et al. Effect of trimetazidine on recurrent angina pectoris and left ventricular structure in elderly multivessel coronary heart disease patients with diabetes mellitus after drug-eluting stent implantation: a single-centre, prospective, randomized, double-blind study at 2-year follow-up[J]. Clin Drug Investig, 2014, 34(4):251-258.
[3] 阮海燕, 王琰. 冠心病心绞痛心血管内科治疗临床分析[J]. 中国保健营养, 2017, 27(26):337-338.
[4] 任楼生.联用氯吡格雷和阿司匹林治疗不稳定型心绞痛的效果分析[J].当代医药论丛,2015,13(10):228-229.
[5] 马玉晴. 舒血宁注射液与血塞通注射液治疗冠心病心绞痛的比较[J]. 临床医药文献电子杂志,2014,1(9):1503-1506.
[6] Kourlaba G, Gourzoulidis G, Tsioufis K, et al. Economic Evaluation Of Trimetazidine In The Management Of Chronic Stable Angina In Greece[J]. Value Health, 2015, 18(7):A391.
[7] Chrusciel P, Rysz J, Banach M. Defining the role of trimetazidine in the treatment of cardiovascular disorders: some insights on its role in heart failure and peripheral artery disease[J]. Drugs, 2014, 74(9): 971-980.
[8] 张万玲. 血塞通对冠心病患者血液流变学的影响及其临床疗效分析[J]. 中国实用医药,2015,10(6):198-199.
[9] 王国立. 阿托伐他汀钙片联合倍他乐克治疗冠心病心绞痛的疗效及对血脂水平及血流动力学的影响[J]. 中国实用医刊, 2017, 44(17): 41-44.
[10] 徐鹏智. 冠心病心绞痛内科治疗临床分析[J]. 中西医结合心血管病电子杂志, 2017, 5(29): 69.
[11] 唐梅森, 黄政德, 向忠军,等. 加味丹参饮联合西药治疗冠心病心绞痛心血瘀阻证68例疗效观察[J]. 中医杂志, 2015, 56(5):395-397.
[12] 黄永柱, 施泳光. 氯吡格雷联合阿司匹林治疗不稳定型心绞痛的效果与安全性[J]. 中国医药导报, 2016, 13(17):129-131.
[13] 蒲月英, 张万超, 何文富. 拜阿司匹林联合氯吡格雷及阿托伐他汀治疗不稳定性心绞痛疗效观察[J]. 西部医学, 2012, 24(1):94-95.
[14] 李小龙, 陆岩, 张琪. 氯吡格雷联合拜阿司匹林治疗稳定型心绞痛效果观察[J]. 山东医药, 2017, 57(42):64-66.
[15] 周芹. 益气活血法治疗老年冠心病心绞痛40例[J]. 河南中医, 2015, 35(9):2079-2081.
[16] 杨东辉. 中西医结合治疗冠心病心绞痛临床疗效观察[J]. 四川中医, 2015(5):67-69.
[17] 徐亚莉, 王曦, 张卫红. 丹蒌片治疗慢性稳定性劳累心绞痛患者的疗效观察[J]. 陕西中医, 2015(7):890-890.
[18] 路晶晶, 雷翔, 商洪才. 丹蒌片治疗痰瘀互阻型稳定型心绞痛的系统评价[J]. 中西医结合心脑血管病杂志, 2017, 15(10):1198-1202.
[19] 郭伟民. 丹蒌片治疗高龄冠心病患者介入支架植入术后心绞痛的疗效观察[J]. 河南医学研究, 2016, 25(7):1282-1283.
[20] 古丽莎, 马志萍. 丹蒌片联合西药治疗冠心病心绞痛的疗效及对血清炎性因子的影响[J]. 中国保健营养, 2017, 27(2): 111.