开喉剑喷雾剂(儿童型)治疗小儿急性咽炎和急性扁桃体炎的用法用量探讨
|
摘要
目的:明确开喉剑喷雾剂(儿童型)治疗动物急性咽炎和急性扁桃体炎的有效剂量范围,为指导临床用法用量提供依据。方法:取幼龄SD大鼠160只,白兔96只,ICR小鼠160只按体质量等级随机分为16组,分别为正常组、模型组、阿莫西林组或利巴韦林、复方一枝黄花组及开喉剑喷雾剂(儿童型)不同给药剂量组;开喉剑喷雾剂(儿童型)不同给药剂量组,分别设置2喷/次,4次/日; 4喷/次,4次/日; 6喷/次,4次/日; 8喷/次,4次/日; 2喷/次,6次/日; 4喷/次,6次/日; 6喷/次,6次/日; 8喷/次,6次/日; 2喷/次,8次/日; 4喷/次,8次/日; 6喷/次,8次/日; 8喷/次,8次/日;共12个给药组。除正常组外,其余各组采用5%氨水咽部喷雾致大鼠急性咽炎、乙型溶血性链球菌感染致家兔急性咽炎和急性扁桃体炎、腺病毒感染致小鼠急性咽炎3种动物模型,通过咽部病变评分及病理检测评价开喉剑喷雾剂(儿童型)的最佳用法用量。结果:与正常组比较,各实验中模型组动物肉眼及病理观察评分均有显著升高(P <0. 01);与模型组比较,开喉剑喷雾剂(儿童型)各给药组均可不同程度减轻大、小鼠咽部病变,减轻家兔咽部组织和扁桃体组织病变,在4～8喷/次,6次/日以及2～6喷/次,8次/日剂量范围内疗效显著,与模型对照组比较有显著性差异。结论:开喉剑喷雾剂(儿童型)治疗急性咽炎和急性扁桃体炎的不同年龄小儿推荐用量为1～3岁:2喷/次,6～8次/日; 4～6岁:3～6喷/次,6～8次/日; 7-12岁:5～8喷/次,6～8次/日。
Objective: To explore the effective dose range of Kaihoujian throat spray( for children) in treating acute pharyngitis and acute tonsillitis,in order to provide the reference for the usage and dosage in clinic.Method: A total of 160 juvenile SD rats were divided into 16 groups according to the body mass grade,namely normal group,model group,amoxicillin or ribavirin group,compound Yizhi Huanghua group and different doses of Kaihoujian( for children) groups. The different doses of Kaihoujian( for children) groups were divided into 12 treatment groups based on 2 sprays/time,4 times/day,4 sprays/time,4 times/day,6 sprays/time,4 times/day,8 sprays/time,4 times/day,2 sprays/time,6 times/day,4 sprays/time,6 times/day,6 sprays/time,6 times/day,8 sprays/time,6 times/day,2 sprays/time,8 times/day,4 sprays/time,8 times/day,6 sprays/time,8 times/day,and 8 sprays/time,8 times/day. Except for normal group,all of the remaining groups were included in three animal models,namely 5% ammonia-induced acute pharyngitis in rat,B type streptococcus haemolyticusinduced acute pharyngitis and tonsillitis in rabbit,and adenovirus-induced acute pharyngitis in mice. Then the optimal usage and dosage of Kaihoujian throat spray( for children) were evaluated based on pharyngeal lesion score and htoxylin eosin( HE) staining. Result: There were significant differences in pharyngeal and tonsil lesions between the model group and the normal group( P < 0. 01). All of the 12 treatment groups could alleviate pharyngeal and tonsil lesions in three animal models,and the best dose range with significant potency were 4 ～ 8 sprays/times,6 times/day and 2 ～ 6 sprays/times,8 times/day( P < 0. 05, P < 0. 01). Conclusion: The clinical usage and dosage of Kaihoujian throat spray( for children) in treating acute pharyngitis and tonsillitis were suggested to be 2 sprays/times,6 ～ 8 times/day for 1 ～ 3 year-old children; 3 ～ 6 sprays/times,6 ～ 8 times/day for 4 ～ 6 year-old children and 5 ～ 8 sprays/times,6 ～ 8 times/day for 7 ～ 12 year-old children.
Objective: To explore the effective dose range of Kaihoujian throat spray( for children) in treating acute pharyngitis and acute tonsillitis,in order to provide the reference for the usage and dosage in clinic.Method: A total of 160 juvenile SD rats were divided into 16 groups according to the body mass grade,namely normal group,model group,amoxicillin or ribavirin group,compound Yizhi Huanghua group and different doses of Kaihoujian( for children) groups. The different doses of Kaihoujian( for children) groups were divided into 12 treatment groups based on 2 sprays/time,4 times/day,4 sprays/time,4 times/day,6 sprays/time,4 times/day,8 sprays/time,4 times/day,2 sprays/time,6 times/day,4 sprays/time,6 times/day,6 sprays/time,6 times/day,8 sprays/time,6 times/day,2 sprays/time,8 times/day,4 sprays/time,8 times/day,6 sprays/time,8 times/day,and 8 sprays/time,8 times/day. Except for normal group,all of the remaining groups were included in three animal models,namely 5% ammonia-induced acute pharyngitis in rat,B type streptococcus haemolyticusinduced acute pharyngitis and tonsillitis in rabbit,and adenovirus-induced acute pharyngitis in mice. Then the optimal usage and dosage of Kaihoujian throat spray( for children) were evaluated based on pharyngeal lesion score and htoxylin eosin( HE) staining. Result: There were significant differences in pharyngeal and tonsil lesions between the model group and the normal group( P < 0. 01). All of the 12 treatment groups could alleviate pharyngeal and tonsil lesions in three animal models,and the best dose range with significant potency were 4 ～ 8 sprays/times,6 times/day and 2 ～ 6 sprays/times,8 times/day( P < 0. 05, P < 0. 01). Conclusion: The clinical usage and dosage of Kaihoujian throat spray( for children) in treating acute pharyngitis and tonsillitis were suggested to be 2 sprays/times,6 ～ 8 times/day for 1 ～ 3 year-old children; 3 ～ 6 sprays/times,6 ～ 8 times/day for 4 ～ 6 year-old children and 5 ～ 8 sprays/times,6 ～ 8 times/day for 7 ～ 12 year-old children.
引文
[1]孙红爽,乜春城,马红芳. 3种中药注射剂辅助治疗儿童化脓性扁桃体炎[J].中国实验方剂学杂志,2015,21(7):183-186.
[2]周慧.开喉剑喷雾剂(儿童型)治疗儿童急性喉炎的有效性和安全性评价[J].现代医药卫生,2013,29(11):1645,1647.
[3]马文建,鲁玉芬,刘永新,李克.小儿肺咳颗粒治疗儿童感染后咳嗽的疗效与作用机制[J].中国实验方剂学杂志,2017,23(14):204-209.
[4]洪铭.冰连清咽喷雾剂治疗咽喉病316例[J].中国中医急症,2010,19(5):875-876
[5]闫俊华,杨勇.开喉剑喷雾剂局部用药治疗儿童急性扁桃体炎50例[J].山东医药,2013,53(48):98-99.
[6]谢莉.开喉剑喷雾剂治疗儿童急性咽喉炎的临床研究[J].临床军医杂志,2015,43(6):610-612.
[7]关晓娟,李劭鹏.开喉剑喷雾剂联合克感利咽口服液治疗儿童急性扁桃体炎临床分析[J].新中医,2016,48(3):158-160.
[8]刘鑫,张四喜,李沁园,等.我院儿科急诊患者超说明书用药分析[J].儿科药学杂志,2017,23(1):36-39.
[9]王雨彤.中国儿童用药现状、问题与对策[D].北京:北京中医药大学,2018.
[10]封银曼,王停,高志卿,等.急性咽炎动物模型研究[J].中国实验方剂学杂志,2001,7(3):52-55.
[11]李向宇,王新帅,王颖.陈皮利咽合剂对急性咽炎模型大鼠白细胞和咽黏膜影响的研究[J].新中医,2013,45(9):303-307.
[12]梁潞,朴晋华,高天红,等.注射用炎琥宁对实验性急性咽炎动物模型的疗效与作用机制研究[J].药物评价研究,2012,35(3):165-168.
[13]张霞,谢雁鸣,李光熙,等.中医药治疗急性咽炎的优势与问题探讨[J].中国中药杂志,2017,42(19):3819-3825.
[14]郭姗姗,包蕾,高英杰,等.金蓝颗粒对病毒感染幼年动物致急性咽炎模型的影响[J].中国实验方剂学杂志,2018,24(13):105-109.
[15]王晓玲,郭春彦.儿童用药剂型与规格的国外现状分析[J].中国药学杂志,2013,48(17):1316-1320.
[16]金丹,田春华,杨月明,等.儿童用药安全现状及政策研究与思考[J].中国药事,2015,29(4):427-431.
[17]杜忠东.儿童用药特点及目前存在的问题[J].中国临床医生杂志,2015,43(12):1-3,100.
[18]柳莹.儿科安全用药的现状及对策研究[J].中国中西医结合儿科学,2015,7(5):515-516.
[19]赵俊杰.开喉剑喷雾剂治疗小儿急性咽炎及急性化脓性扁桃体炎临床观察[J].新中医,2014,46(10):147-149.
[20]李涤静.开喉剑喷雾剂治疗小儿急性化脓性扁桃体炎临床观察[J].新中医,2016,48(10):117-119.
[2]周慧.开喉剑喷雾剂(儿童型)治疗儿童急性喉炎的有效性和安全性评价[J].现代医药卫生,2013,29(11):1645,1647.
[3]马文建,鲁玉芬,刘永新,李克.小儿肺咳颗粒治疗儿童感染后咳嗽的疗效与作用机制[J].中国实验方剂学杂志,2017,23(14):204-209.
[4]洪铭.冰连清咽喷雾剂治疗咽喉病316例[J].中国中医急症,2010,19(5):875-876
[5]闫俊华,杨勇.开喉剑喷雾剂局部用药治疗儿童急性扁桃体炎50例[J].山东医药,2013,53(48):98-99.
[6]谢莉.开喉剑喷雾剂治疗儿童急性咽喉炎的临床研究[J].临床军医杂志,2015,43(6):610-612.
[7]关晓娟,李劭鹏.开喉剑喷雾剂联合克感利咽口服液治疗儿童急性扁桃体炎临床分析[J].新中医,2016,48(3):158-160.
[8]刘鑫,张四喜,李沁园,等.我院儿科急诊患者超说明书用药分析[J].儿科药学杂志,2017,23(1):36-39.
[9]王雨彤.中国儿童用药现状、问题与对策[D].北京:北京中医药大学,2018.
[10]封银曼,王停,高志卿,等.急性咽炎动物模型研究[J].中国实验方剂学杂志,2001,7(3):52-55.
[11]李向宇,王新帅,王颖.陈皮利咽合剂对急性咽炎模型大鼠白细胞和咽黏膜影响的研究[J].新中医,2013,45(9):303-307.
[12]梁潞,朴晋华,高天红,等.注射用炎琥宁对实验性急性咽炎动物模型的疗效与作用机制研究[J].药物评价研究,2012,35(3):165-168.
[13]张霞,谢雁鸣,李光熙,等.中医药治疗急性咽炎的优势与问题探讨[J].中国中药杂志,2017,42(19):3819-3825.
[14]郭姗姗,包蕾,高英杰,等.金蓝颗粒对病毒感染幼年动物致急性咽炎模型的影响[J].中国实验方剂学杂志,2018,24(13):105-109.
[15]王晓玲,郭春彦.儿童用药剂型与规格的国外现状分析[J].中国药学杂志,2013,48(17):1316-1320.
[16]金丹,田春华,杨月明,等.儿童用药安全现状及政策研究与思考[J].中国药事,2015,29(4):427-431.
[17]杜忠东.儿童用药特点及目前存在的问题[J].中国临床医生杂志,2015,43(12):1-3,100.
[18]柳莹.儿科安全用药的现状及对策研究[J].中国中西医结合儿科学,2015,7(5):515-516.
[19]赵俊杰.开喉剑喷雾剂治疗小儿急性咽炎及急性化脓性扁桃体炎临床观察[J].新中医,2014,46(10):147-149.
[20]李涤静.开喉剑喷雾剂治疗小儿急性化脓性扁桃体炎临床观察[J].新中医,2016,48(10):117-119.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |