Combination of pharmacological analgesics and microwave irradiation of an acupuncture point for suppression of visceral pain in mice: Role of the opioid and serotonergic cerebral systems
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- 作者：E. N. Nesin ; E. V. Gura and M. D. Kolbun
- 关键词：visceral pain ; acetate test ; pharmacological analgesia ; microwave irradiation ; acupuncture point ; antinociceptive cerebral systems
- 刊名：Neurophysiology
- 出版时间：November, 2007
- 出版年：2007
- 期刊代码：28_00902977
- 类别：en
- 卷：39
- 期：6
- 页码：406-413
- 数据来源：sp
摘要
We studied suppression of pain-related reactions induced in mice by i.p. injection of 0.08 ml of a 2%solution of acetic acid using pharmacological analgesics (analgin and tramadol) combined with low-intensity microwave irradiation of an acupuncture point (AP) E-36 (frequency 30 to 300 GHz and power rate density 3路10−9 W/cm2). The respective effects were also observed under conditions of suppression of the functions of opioid and serotonergic cerebral systems using injections of, respectively, naloxone and DL-p-chlorophenylalanine (p-CPA). We found that antinociceptive effects provided by analgesics used in a 50%mean single dose in the combination with microwave irradiation of the AP were significantly more intense than those induced by isolated injection of analgesics used in both 50%and full mean single doses and isolated microwave irradiation of the AP E-36. After injections of naloxone, analgesic effects caused by the combined action of analgin and microwave irradiation of the AP were considerably smaller. At the same time, after injection of p-CPA, analgesic effects, provided by the combination of injection of pharmacological agents and microwave irradiation of the AP, weakened in the case of use of both analgesics. This was manifested in a significant increase in the total duration of pain-related behavioral reactions. Therefore, the studied analgesic effects observed in the examined animal groups are realized due to the involvement of the opioid and serotonergic cerebral systems.