Comparative differential proteomic analysis of minimal change disease and focal segmental glomerulosclerosis

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• 作者：Vanessa Pérez ; Dolores López ; Ester Boixadera ; Meritxell Ibernón…
• 关键词：Focal segmental glomerulosclerosis ; Glomerular disease ; Mass spectrometry ; Minimal change disease ; Proteomics ; Urine ; 2D ; DIGE
• 刊名：BMC Nephrology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：18
• 期：1
• 全文大小：952KB
• 刊物主题：Nephrology; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-2369
• 卷排序：18

文摘

BackgroundMinimal change disease (MCD) and primary focal segmental glomerulosclerosis (FSGS) are glomerular diseases characterized by nephrotic syndrome. Their diagnosis requires a renal biopsy, but it is an invasive procedure with potential complications. In a small biopsy sample, where only normal glomeruli are observed, FSGS cannot be differentiated from MCD. The correct diagnosis is crucial to an effective treatment, as MCD is normally responsive to steroid therapy, whereas FSGS is usually resistant.