On-treatment markers as predictors to guide anti-EGFR MoAb treatment in metastatic colorectal cancer: a systematic review with meta-analysis

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• 作者：Jing Hu ; Zhen Zhang ; Rui Zheng ; Lei Cheng ; Mi Yang&#8230
• 关键词：Colorectal cancer ; On ; treatment markers ; Skin toxicity ; Early tumor shrinkage ; Cetuximab ; Panitumumab
• 刊名：Cancer Chemotherapy and Pharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：79
• 期：2
• 页码：275-285
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Oncology; Pharmacology/Toxicology; Cancer Research;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-0843
• 卷排序：79

文摘

PurposeSkin toxicity (ST) and early tumor shrinkage (ETS) are early phenomenon during the anti-epidermal growth factor receptor (EGFR) monoclonal antibody (MoAb) treatment. We conducted a meta-analysis and included relevant studies that reported the impact of ST and ETS on survival- and life quality-based outcome of metastatic colorectal cancer (mCRC) patients treated with anti-EGFR MoAb.