Intravenous pretreatment with emulsified isoflurane preconditioning protects kidneys against ischemia/reperfusion injury in rats

详细信息    查看全文

• 作者：Zhaojun Qin ; En Lv ; Leyun Zhan ; Xiangfei Xing ; Jianli Jiang…
• 关键词：Emulsified isoflurane ; Acute renal ischemia ; Preconditioning ; Inflammation ; Oxidative stress
• 刊名：BMC Anesthesiology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：14
• 期：1
• 全文大小：334 KB
• 参考文献：1. Devarajan, P (2006) Update on mechanisms of ischemic acute kidney injury. J Am Soc Nephrol 17: pp. 1503-1520 CrossRef
  2. Thadhani, R, Pascual, M, Bonventre, JV (1996) Acute renal failure. N Engl J Med 334: pp. 1448-1460 CrossRef
  3. Xiao, YY, Chang, YT, Ran, K, Liu, JP (2011) Delayed preconditioning by sevoflurane elicits changes in the mitochondrial proteome in ischemia-reperfused rat hearts. Anesth Analg 113: pp. 224-232 CrossRef
  4. Fortis, S, Spieth, PM, Lu, WY, Parotto, M, Haitsma, JJ, Slutsky, AS, Zhong, N, Mazer, CD, Zhang, H (2012) Effects of anesthetic regimes on inflammatory responses in a rat model of acute lung injury. Intensive Care Med 38: pp. 1548-1555 CrossRef
  5. Johnsen, D, Murphy, SJ (2011) Isoflurane preconditioning protects neurons from male and female mice against oxygen and glucose deprivation and is modulated by estradiol only in neurons from female mice. Neuroscience 199: pp. 368-374 CrossRef
  6. Lv, X, Yang, L, Tao, K, Liu, Y, Yang, T, Chen, G, Yu, W, Lv, H, Wu, F (2011) Isoflurane preconditioning at clinically relevant doses induce protective effects of hemeoxygenase-1 on hepatic ischemia reperfusion in rats. BMC Gastroenterol 11: pp. 31 CrossRef
  7. Song, JH, Kim, M, Park, SW, Chen, SW, Pitson, SM, Lee, HT (2010) Isoflurane via TGF-beta1 release increases caveolae formation and organizes sphingosine kinase signaling in renal proximal tubules. Am J Physiol Renal Physiol 298: pp. F1041-F1050 CrossRef
  8. Kim, M, Park, SW, Kim, M, D’Agati, VD, Lee, HT (2011) Isoflurane activates intestinal sphingosine kinase to protect against renal ischemia-reperfusion-induced liver and intestine injury. Anesthesiology 114: pp. 363-373 CrossRef
  9. Lee, HT, Ota-setlik, A, Fu, Y, Nasr, SH, Emala, CW (2004) Differential protective effects of volatile anesthetics against renal ischemia-reperfusion injury in vivo. Anesthesiology 101: pp. 1313-1324 CrossRef
  10. Hashiguchi, H, Morooka, H, Miyoshi, H, Matsumoto, M, Koji, T, Sumikawa, K (2005) Isoflurane protects renal function against ischemia and reperfusion through inhibition of protein kinases, JNK and ERK. Anesth Analg 101: pp. 1584-1589 CrossRef
  11. Kim, M, Ham, A, Kim, JY, Browm, KM, D’Agati, VD, Lee, HT (2013) The volatile anesthetic isoflurane induces ecto-5-nucleotidase (CD73) to protect against renal ischemia and reperfusion injury. Kidney Int 84: pp. 90-103 CrossRef
  12. Zhang, L, Huang, H, Cheng, J, Liu, J, Zhao, H, Vizcaychipi, MP, Ma, D (2011) Pre-treatment with isoflurane ameliorates renal ischemia-reperfusion injury in mice. Life Sci 88: pp. 1102-1107 CrossRef
  13. Landoni, G, Fochi, O, Torri, G (2008) Cardiac protection by volatile anaesthetics: a review. Curr Vasc Pharmacol 6: pp. 108-111 CrossRef
  14. Fukazawa, K, Lee, HT (2014) Volatile anesthetics and AKI: risks, mechanisms, and apotential therapeutic window. J Am Soc Nephrol.
  15. Hu, ZY, Liu, J (2009) Effects of emulsified isoflurane on haemodynamics and cardiomyocyte apoptosis in rats with myocardial ischaemia. Clin Exp Pharmacol Physiol 36: pp. 776-783 CrossRef
  16. Lucchinetti, E, Schaub, MC, Zaugg, M (2008) Emulsified intravenous versus evaporated inhaled isoflurane for heart protection:old wine in a new bot
• 刊物主题：Anesthesiology; Internal Medicine; Emergency Medicine; Intensive / Critical Care Medicine;
• 出版者：BioMed Central
• ISSN：1471-2253

文摘

Background Emulsified isoflurane (EIso) is a novel intravenous general anesthetic, which can provide rapid anesthetic induction and recovery. EIso preconditioning could attenuate heart, lung and liver ischemia/reperfusion (I/R) injury. We tested the hypothesis that intravenous pretreatment with EIso would protect kidneys against I/R injury by inhibiting systemic inflammatory responses and improving renal antioxidative ability. Methods Rats were randomly divided into these six groups: sham, I/R, intralipid, 1, 2 or 4?ml/kg EIso. Rats were subjected to 45?min left renal pedicle occlusion followed by 3?h reperfusion after right nephrectomy. Rat were treated with intravenous 8% EIso with 1, 2 or 4?ml/kg, or 30% intralipid with 2?ml/kg for 30?min before ischemia, respectively. After reperfusion, renal functional parameters, serum mediator concentrations and markers of oxidative stress in kidney tissues were determined, and renal histopathological analysis were performed. Results Serum creatinine, blood urea nitrogen, cystatin c, tumor necrosis factor-α, interleukin-6, and interleukin-10 concentrations were significantly increased after renal I/R as compared to the sham group. So was renal tissue MDA content and histological scores, but renal tissue SOD activity was decreased. Additionally, severe morphological damages were observed in these study groups. In contrast, 2 or 4?ml/kg EIso reduced serum creatinine, blood urea nitrogen, cystatin c, tumor necrosis factor-α, and interleukin-6 levels, decreased renal tissue MDA content and histological scores, increased serum interleukin-10 level and tissue SOD activity as compared to the I/R, intralipid and 1?ml/kg EIso groups. Renal morphological damages were alleviated after pretreatment of 2 or 4?ml/kg EIso. Conclusions Intravenous EIso produces preconditioning against renal I/R injury in rats, which might be mediated by attenuating inflammation and increasing antioxidation ability.