Carbon dots doped with nitrogen and sulfur and loaded with copper(II) as a "turn-on" fluorescent probe for cystein, glutathione and homocysteine

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• 作者：Ying Guo ; Lianli Yang ; Wuwu Li ; Xiaofang Wang ; Yonghui Shang…
• 关键词：Quenching ; Fluorescence recovery ; Quantum yield ; Luminescence ; Imaging ; Transmission electron microscopy
• 刊名：Microchimica Acta
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：183
• 期：4
• 页码：1409-1416
• 全文大小：516 KB
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• 作者单位：Ying Guo (1)
  Lianli Yang (1)
  Wuwu Li (1)
  Xiaofang Wang (1)
  Yonghui Shang (1)
  Baoxin Li (2)
  
  1. College of Chemistry & Chemical Engineering, Xianyang Normal University, Xianyang, 712000, China
  2. Key laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi’an, 710062, China
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Analytical Chemistry
  Inorganic Chemistry
  Physical Chemistry
  Characterization and Evaluation Materials
  Monitoring, Environmental Analysis and Environmental Ecotoxicology
  
• 出版者：Springer Wien
• ISSN：1436-5073

文摘

We report on the synthesis of fluorescent carbon dots doped with nitrogen and sulfur (N,S-CDs) via a hydrothermal process in pure water and starting from a mixture of alfalfa and garlic. Compared to N-doped CDs, the N,S-CDs exhibit a high fluorescence quantum yield (10 %) and a more longwave emission maximum (at 481 nm). The results also pave the way to tune the luminescence of CDs. The fluorescence of the N,S-CDs is quenched by Cu(II) ions but is recovered by addition of any of the biothiols cystein, glutathione or homocysteine. This turn-on effect was exploited to design a method for the quantification of these thiols in concentrations as low as 86 nM. The method was successfully applied to the determination of Cys in (spiked) human serum samples.