Cannabinoid CB1 receptor signaling dichotomously modulates inhibitory and excitatory synaptic transmission in rat inner retina
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- 作者：Xiao-Han Wang ; Yi Wu ; Xiao-Fang Yang ; Yanying Miao…
- 关键词：Cannabinoid CB1 receptor ; Synaptic transmission ; Inner retina ; mIPSCs ; mEPSCs ; Calcium channels
- 刊名：Brain Structure and Function
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：221
- 期：1
- 页码：301-316
- 全文大小：3,830 KB
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Yi Wu (1)
Xiao-Fang Yang (1)
Yanying Miao (1)
Chuan-Qiang Zhang (1)
Ling-Dan Dong (1)
Xiong-Li Yang (1)
Zhongfeng Wang (1)
1. Institutes of Brain Science, Institute of Neurobiology, State Key Laboratory of Medical Neurobiology, Fudan University, 138 Yixueyuan Rd, Shanghai, 200032, China - 刊物主题：Neurosciences; Cell Biology; Neurology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1863-2661
文摘
In the inner retina, ganglion cells (RGCs) integrate and process excitatory signal from bipolar cells (BCs) and inhibitory signal from amacrine cells (ACs). Using multiple labeling immunohistochemistry, we first revealed the expression of the cannabinoid CB1 receptor (CB1R) at the terminals of ACs and BCs in rat retina. By patch-clamp techniques, we then showed how the activation of this receptor dichotomously regulated miniature inhibitory postsynaptic currents (mIPSCs), mediated by GABAA receptors and glycine receptors, and miniature excitatory postsynaptic currents (mEPSCs), mediated by AMPA receptors, of RGCs in rat retinal slices. WIN55212-2 (WIN), a CB1R agonist, reduced the mIPSC frequency due to an inhibition of L-type Ca2+ channels no matter whether AMPA receptors were blocked. In contrast, WIN reduced the mEPSC frequency by suppressing T-type Ca2+ channels only when inhibitory inputs to RGCs were present, which could be in part due to less T-type Ca2+ channels of cone BCs, presynaptic to RGCs, being in an inactivation state under such condition. This unique feature of CB1R-mediated retrograde regulation provides a novel mechanism for modulating excitatory synaptic transmission in the inner retina. Moreover, depolarization of RGCs suppressed mIPSCs of these cells, an effect that was eliminated by the CB1R antagonist SR141716, suggesting that endocannabinoid is indeed released from RGCs. Keywords Cannabinoid CB1 receptor Synaptic transmission Inner retina mIPSCs mEPSCs Calcium channels