Fanconi anemia genes in lung adenocarcinoma- a pathway-wide study on cancer susceptibility

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• 作者：Shi-Yi Yang ; Chia-Ni Hsiung ; Yao-Jen Li ; Gee-Chen Chang…
• 关键词：Lung adenocarcinoma ; DNA repair ; Fanconi anemia ; Genetic susceptibility ; Polymorphism
• 刊名：Journal of Biomedical Science
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：23
• 期：1
• 全文大小：1,292 KB
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• 作者单位：Shi-Yi Yang (1) (2)
  Chia-Ni Hsiung (3)
  Yao-Jen Li (2)
  Gee-Chen Chang (4)
  Ying-Huang Tsai (5)
  Kuan-Yu Chen (6)
  Ming-Shyan Huang (7)
  Wu-Chou Su (8)
  Yuh-Min Chen (9)
  Chao A. Hsiung (10)
  Pan-Chyr Yang (6)
  Chien-Jen Chen (1) (2)
  Pei-Ei Wu (11) (3)
  Jyh-Cherng Yu (14)
  Chen-Yang Shen (11) (12) (13) (3)
  Huan-Ming Hsu (14)
  
  1. Genomics Research Center, Taipei, Taiwan
  2. Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
  3. Institute of Biomedical Sciences, Taipei, Taiwan
  4. Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
  5. Department of Pulmonary and Critical Care, Chang Gung Memorial Hospital, Lincou, Taiwan
  6. Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
  7. Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
  8. Department of Internal Medicine, National Cheng Kung University Hospital and College of Medicine, Tainan, Taiwan
  9. Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan
  10. Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan
  11. Taiwan Biobank, Taipei, Taiwan
  14. Division of General Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
  12. Life Science Library, Academia Sinica, Taipei, Taiwan
  13. Graduate Institute of Environmental Science, China Medical University, Taichung, Taiwan
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Biomedicine
  
• 出版者：Springer Netherlands
• ISSN：1423-0127

文摘

Background Carcinogens in cigarette smoke can induce the formation of DNA-DNA cross-links, which are repaired by the Fanconi anemia (FA) pathway, and it is tempting to speculate that this pathway is involved in lung tumorigenesis. This study is to determine whether genetic polymorphism of the FA genes is associated with an elevated risk of lung adenocarcinoma, and whether the association between genotypes and risk is modified by exposure to cigarette smoke.