Long noncoding RNA papillary thyroid carcinoma susceptibility candidate 3 (PTCSC3) inhibits proliferation and invasion of glioma cells by suppressing the Wnt/β-catenin signaling pathway
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- 作者：Shujun Xia ; Ri Ji ; Weiwei Zhan
- 关键词：LncRNA PTCSC3 ; Glioma ; Proliferation ; Invasion ; EMT ; Wnt signal
- 刊名：BMC Neurology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：17
- 期：1
- 全文大小：4289KB
- 刊物主题：Neurology; Neurochemistry; Neurosurgery;
- 出版者：BioMed Central
- ISSN：1471-2377
- 卷排序：17
文摘
BackgroundThe dysregulation of long noncoding RNAs (lncRNAs) has been identified in a variety of cancers. An increasing number of studies have found the critical role of lncRNAs in the regulation of cellular processes, such as proliferation, invasion and differentiation. Long noncoding RNA papillary thyroid carcinoma susceptibility candidate 3 (PTCSC3) is a novel lncRNA that was primarily detected in papillary thyroid carcinoma. However, the biological function and molecular mechanism of lncRNA PTCSC3 in glioma are still unknown.