Cytokines: shifting the balance between glioma cells and tumor microenvironment after irradiation

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• 作者：Wei Zhou (1)
  Zheng Jiang (2)
  Xingang Li (2)
  Yangyang Xu (2)
  Zhenyu Shao (1)
  
  1. Department of Radiation Oncology ; Cancer Centre ; Qilu Hospital ; Shandong University ; 44 Wenhuaxi Road ; Jinan ; 250012 ; Shandong ; China
  2. Department of Neurosurgery ; Qilu Hospital ; Shandong University ; 44 Wenhuaxi Road ; Jinan ; 250012 ; Shandong ; China
  
• 关键词：Glioma ; Cytokine ; Cancer immunology ; Radiation therapy
• 刊名：Journal of Cancer Research and Clinical Oncology
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：141
• 期：4
• 页码：575-589
• 全文大小：300 KB
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Cancer Research
  Internal Medicine
  Hematology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1335

文摘

Malignant gliomas invariably recur after irradiation, showing radioresistance. Meanwhile, cranial irradiation can bring some risk for developing cognitive dysfunction. There is increasing evidence that cytokines play their peculiar roles in these processes. On the one hand, cytokines directly influence the progression of malignant glioma, promoting or suppressing tumor progression. On the other hand, cytokines indirectly contribute to the immunologic response against gliomas, exhibiting pro-inflammatory or immunosuppressive activities. We propose that cytokines are not simply unregulated products from tumor cells or immune cells, but mediators finely adjust the balance between glioma cells and tumor microenvironment after irradiation. The paper, therefore, focuses on the changes of cytokines after irradiation, analyzing how these mediate the response of tumor cells and normal cells to irradiation. In addition, cytokine-based immunotherapeutic strategies, accompanied with irradiation, for the treatment of gliomas are also discussed.