Tankyrase inhibition impairs directional migration and invasion of lung cancer cells by affecting microtubule dynamics and polarity signals

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• 作者：Barbara Lupo ; Jorge Vialard ; Francesco Sassi ; Patrick Angibaud…
• 关键词：Cancer cell invasion ; Cell migration ; HGF ; Microtubules ; Polarity signals ; Tankyrase
• 刊名：BMC Biology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：14
• 期：1
• 全文大小：2,122 KB
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• 作者单位：Barbara Lupo (1) (2)
  Jorge Vialard (3)
  Francesco Sassi (2)
  Patrick Angibaud (4)
  Alberto Puliafito (5)
  Emanuela Pupo (6)
  Letizia Lanzetti (1) (6)
  Paolo M. Comoglio (1) (7)
  Andrea Bertotti (1) (2) (8)
  Livio Trusolino (1) (2)
  
  1. Department of Oncology, University of Torino Medical School, 10060, Candiolo, Torino, Italy
  2. Laboratory of Translational Cancer Medicine, Candiolo Cancer Institute – FPO IRCCS, Strada Provinciale 142, km 3.95, 10060, Candiolo, Torino, Italy
  3. Janssen Research & Development, a Division of Janssen Pharmaceutica NV, 2340, Beerse, Belgium
  4. Janssen Research & Development, a Division of Janssen-Cilag, 27106, Val-de-Reuil, Cedex, France
  5. Laboratory of Cell Migration, Candiolo Cancer Institute – FPO IRCCS, 10060, Candiolo, Torino, Italy
  6. Laboratory of Membrane Trafficking, Candiolo Cancer Institute – FPO IRCCS, 10060, Candiolo, Torino, Italy
  7. Experimental Clinical Molecular Oncology, Candiolo Cancer Institute – FPO IRCCS, 10060, Candiolo, Torino, Italy
  8. Istituto Nazionale di Biostrutture e Biosistemi, INBB, 00136, Rome, Italy
  
• 刊物主题：Life Sciences, general;
• 出版者：BioMed Central
• ISSN：1741-7007

文摘

Background Tankyrases are poly(adenosine diphosphate)-ribose polymerases that contribute to biological processes as diverse as modulation of Wnt signaling, telomere maintenance, vesicle trafficking, and microtubule-dependent spindle pole assembly during mitosis. At interphase, polarized reshaping of the microtubule network fosters oriented cell migration. This is attained by association of adenomatous polyposis coli with the plus end of microtubules at the cortex of cell membrane protrusions and microtubule-based centrosome reorientation towards the migrating front.