Optimal FSH usage in revascularization of allotransplanted ovarian tissue in mice
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- 作者：Wen-Zhi Ma ; Xiao-Min Zheng ; Chang-Chun Hei ; Cheng-Jun Zhao…
- 关键词：FSH ; Ovarian tissue ; Revascularization ; VEGF ; bFGF
- 刊名：Journal of Ovarian Research
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：10
- 期：1
- 全文大小：9509KB
- 刊物主题：Gynecology; Reproductive Medicine;
- 出版者：BioMed Central
- ISSN：1757-2215
- 卷排序：10
文摘
BackgroudOvarian transplantation is a useful method for preserving the fertility of young women with cancer who undergo radiotherapy and chemotherapy. Follicle-stimulating hormone (FSH) is use to protect transplanted ovarian tissues from ischemia injury through promoting revascularization after transplantation, but the side effect of high level FSH is ovarian overstimulation leading to substantial follicular loss. In this study, we investigated the optimal usage of FSH on revascularization in the in vitro cultured ovarian tissues before and after transplantation.