Oxidative status predicts quality in human mesenchymal stem cells

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• 作者：Alessandro Bertolo ; Simona Capossela ; Gion Fränkl…
• 关键词：Human mesenchymal stem cells ; Cell senescence ; Cell differentiation ; Antioxidant enzymes ; Mitochondrial biogenesis ; Methylene blue
• 刊名：Stem Cell Research & Therapy
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：8
• 期：1
• 全文大小：1449KB
• 刊物主题：Stem Cells; Cell Biology;
• 出版者：BioMed Central
• ISSN：1757-6512
• 卷排序：8

文摘

BackgroundHuman bone marrow-derived mesenchymal stem cells (MSC) are adult progenitor cells with great potential for application in cell-based therapies. From a cell-based therapy perspective, there are two limitations to MSC use: (1) these therapies require large numbers of cells, and long-term expansion of MSC in vitro promotes replicative senescence; and (2) patient variability is a challenge for defining MSC quality standards for transplantation. This study aimed to determine whether low or high oxidative status of MSC correlate with changes in cell expansion and differentiation potentials.