Cardiovascular regeneration

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• 作者：Ronald A Li (1) (2)
  
  1. Stem Cell and Regenerative Medicine Consortium ; Department of Physiology ; LKS Faculty of Medicine ; University of Hong Kong ; Pok Fu Lam ; Hong Kong
  2. Center of Cardiovascular Research ; Icahn School of Medicine at Mount Sinai ; New York ; NY ; USA
  
• 刊名：Stem Cell Research & Therapy
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：5
• 期：6
• 全文大小：180 KB
• 参考文献：1. Hulot, JS, Stillitano, F, Salem, JE, Kovacic, JC, Fuster, V, Hajjar, RJ (2014) Considerations for pre-clinical models and clinical trials of pluripotent stem cell-derived cardiomyocytes. Stem Cell Res Ther 5: pp. 1 CrossRef
  2. Liao, SY, Tse, HF (2013) Multipotent (adult) and pluripotent stem cells for heart regeneration: what are the pros and cons?. Stem Cell Res Ther 4: pp. 151 CrossRef
  3. Sharma, A, Wu, JC, Wu, SM (2013) Induced pluripotent stem cell-derived cardiomyocytes for cardiovascular disease modeling and drug screening. Stem Cell Res Ther 4: pp. 150 CrossRef
  4. Keung, W, Boheler, KR, Li, RA (2014) Developmental cues for the maturation of metabolic, electrophysiological and calcium handling properties of human pluripotent stem cell-derived cardiomyocytes. Stem Cell Res Ther 5: pp. 17 CrossRef
  5. Zhu, R, Blazeski, A, Poon, E, Costa, KD, Tung, L, Boheler, KR (2014) Physical developmental cues for the maturation of human pluripotent stem cell-derived cardiomyocytes. Stem Cell Res Ther 5: pp. 117 CrossRef
  6. Chen, A, Ting, S, Seow, J, Reuveny, S, Oh, S (2014) Considerations in designing systems for large scale production of human cardiomyocytes from pluripotent stem cells. Stem Cell Res Ther 5: pp. 12 CrossRef
  
• 刊物主题：Stem Cells; Cell Biology;
• 出版者：BioMed Central
• ISSN：1757-6512

文摘

Heart disease remains the number one cause of death in developed countries. Loss of cardiomyocytes (CMs) due to aging or pathophysiological conditions (for example, myocardial infarction) is generally considered irreversible, and can lead to lethal conditions from cardiac arrhythmias to heart failure. Human pluripotent stem cells (PSCs), including embryonic stem cells and induced pluripotent stem cells (iPSCs), can self-renew while maintaining their pluripotency to differentiate into all cell types, including CMs. As such, PSCs represent an unprecedented unlimited ex vivo cell source. In the present thematic series, we have solicited seven review articles to discuss the current state-of-the-art PSC-based approaches for such applications as disease modeling, discovery of novel drugs and therapeutics, cardiotoxicity screening and cell-based myocardial repair, as well as the associated hurdles and potential solutions.