用户名： 密码： 验证码：
Role of CD40 ligation in dendritic cell semimaturation
详细信息    查看全文
  • 作者：Anna-Maria Gerlach (1)
    Alexander Steimle (1)
    Lea Krampen (1)
    Alexandra Wittmann (1)
    Kerstin Gronbach (1)
    Julia Geisel (1)
    Ingo B Autenrieth (1)
    Julia-Stefanie Frick (1)
  • 关键词：Dendritic cells ; CD40 ligation ; Maturation ; Cytokine ; MAP Kinase ; Homoeostasis ; T ; cell
  • 刊名：BMC Immunology
  • 出版年：2012
  • 出版时间：December 2012
  • 年：2012
  • 卷：13
  • 期：1
  • 全文大小：493KB
  • 参考文献：1. Re F, Strominger JL: Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells. / J Biol Chem 2001, 276:37692-7699. CrossRef
    2. Waidmann M, Bechtold O, Frick JS, Lehr HA, Schubert S, Dobrindt U, Loeffler J, Bohn E, Autenrieth IB: Bacteroides vulgatus protects against Escherichia coli-induced colitis in gnotobiotic interleukin-2-deficient mice. / Gastroenterology 2003, 125:162-77. CrossRef
    3. Muller M, Fink K, Geisel J, Kahl F, Jilge B, Reimann J, Mach N, Autenrieth IB, Frick JS: Intestinal colonization of IL-2 deficient mice with non-colitogenic B. vulgatus prevents DC maturation and T-cell polarization. / PLoS One 2008, 3:e2376. CrossRef
    4. Frick JS, Zahir N, Muller M, Kahl F, Bechtold O, Lutz MB, Kirschning CJ, Reimann J, Jilge B, Bohn E, Autenrieth IB: Colitogenic and non-colitogenic commensal bacteria differentially trigger DC maturation and Th cell polarization: An important role for IL-6. / Eur J Immunol 2006, 36:1537-547. CrossRef
    5. Geisel J, Kahl F, Muller M, Wagner H, Kirschning CJ, Autenrieth IB, Frick JS: IL-6 and Maturation Govern TLR2 and TLR4 Induced TLR Agonist Tolerance and Cross-Tolerance in Dendritic Cells. / J Immunol 2007, 179:5811-818.
    6. Bennett SR, Carbone FR, Karamalis F, Flavell RA, Miller JF, Heath WR: Help for cytotoxic-T-cell responses is mediated by CD40 signalling. / Nature 1998, 393:478-80. CrossRef
    7. Chang WL, Baumgarth N, Eberhardt MK, Lee CY, Baron CA, Gregg JP, Barry PA: Exposure of myeloid dendritic cells to exogenous or endogenous IL-10 during maturation determines their longevity. / J Immunol 2007, 178:7794-804.
    8. Caux C, Massacrier C, Vanbervliet B, Dubois B, Van KC, Durand I, Banchereau J: Activation of human dendritic cells through CD40 cross-linking. / J Exp Med 1994, 180:1263-272. CrossRef
    9. Cella M, Scheidegger D, Palmer-Lehmann K, Lane P, Lanzavecchia A, Alber G: Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. / J Exp Med 1996, 184:747-52. CrossRef
    10. Koch F, Stanzl U, Jennewein P, Janke K, Heufler C, Kampgen E, Romani N, Schuler G: High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. / J Exp Med 1996, 184:741-46. CrossRef
    11. Toso JF, Lapointe R, Hwu P: CD40 ligand and lipopolysaccharide enchance the in vitro generation of melanoma-reactive T-cells. / J Immunol Methods 2002 Jan 1,259(1-):181-90. CrossRef
    12. Bjorck P, Banchereau J, Flores-Romo L: CD40 ligation counteracts Fas-induced apoptosis of human dendritic cells. / Int Immunol 1997, 9:365-72. CrossRef
    13. Wong BR, Josien R, Lee SY, Sauter B, Li HL, Steinman RM, Choi Y: TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor. / J Exp Med 1997, 186:2075-080. CrossRef
    14. Boonstra A, Rajsbaum R, Holman M, Marques R, sselin-Paturel C, Pereira JP, Bates EE, Akira S, Vieira P, Liu YJ, Trinchieri G, O'Garra A: Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals. / J Immunol 2006, 177:7551-558.
    15. Kuniyoshi JS, Kuniyoshi CJ, Lim AM, Wang FY, Bade ER, Lau R, Thomas EK, Weber JS: Dendritic cell secretion of IL-15 is induced by recombinant huCD40LT and augments the stimulation of antigen-specific cytolytic T cells. / Cell Immunol 1999, 193:48-8. CrossRef
    16. Holscher C: The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseases. / Med Microbiol Immunol 2004, 193:1-7. CrossRef
    17. Trinchieri G: Interleukin-12 and the regulation of innate resistance and adaptive immunity. / Nat Rev Immunol 2003, 3:133-46. CrossRef
    18. Hommes DW, Peppelenbosch MP, van Deventer SJ: Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets. / Gut 2003, 52:144-51. CrossRef
    19. Chang L, Karin M: Mammalian MAP kinase signalling cascades. / Nature 2001, 410:37-0. CrossRef
    20. Johnson GL, Lapadat R: Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. / Science 2002, 298:1911-912. CrossRef
    21. Grassl GA, Kracht M, Wiedemann A, Hoffmann E, Aepfelbacher M, Eichel-Streiber C, Bohn E, Autenrieth IB: Activation of NF-kappaB and IL-8 by Yersinia enterocolitica invasin protein is conferred by engagement of Rac1 and MAP kinase cascades. / Cell Microbiol 2003, 5:957-71. CrossRef
    22. Brook M, Sully G, Clark AR, Saklatvala J: Regulation of tumour necrosis factor alpha mRNA stability by the mitogen-activated protein kinase p38 signalling cascade. / FEBS Lett 2000, 483:57-1. CrossRef
    23. Wang SW, Pawlowski J, Wathen ST, Kinney SD, Lichenstein HS, Manthey CL: Cytokine mRNA decay is accelerated by an inhibitor of p38-mitogen-activated protein kinase. / Inflamm Res 1999, 48:533-38. CrossRef
    24. Dohnal AM, Luger R, Paul P, Fuchs D, Felzmann : CD40 ligation restores type 1 polarizing capacity in TLR4-activated dendritic cells that have ceased interleukin-12 expression. / J Cell Mol Med T 2009, 13:1741-750. CrossRef
    25. Lapointe R, Toso JF, Butts C, Young HA, Hwu P: Human dendritic cells require multiple activation signals for the efficient generation of tumor antigen-specific T lymphocytes. / Eur J Immunol 2000, 30:3291-298. CrossRef
    26. Dhodapkar MV, Steinman RM, Krasovsky J, Munz C, Bhardwaj N: Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. / J Exp Med 2001, 193:233-38. CrossRef
    27. Hawiger D, Inaba K, Dorsett Y, Guo M, Mahnke K, Rivera M, Ravetch JV, Steinman RM, Nussenzweig MC: Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. / J Exp Med 2001, 194:769-79. CrossRef
    28. Steinman RM, Hawiger D, Nussenzweig MC: Tolerogenic dendritic cells. / Annu Rev Immunol 2003, 21:685-11. CrossRef
    29. van den Broek M: Dendritic cells break bonds to tolerize. / Immunity 2007, 27:544-46. CrossRef
    30. Fujii S, Liu K, Smith C, Bonito AJ, Steinman RM: The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation. / J Exp Med 2004, 199:1607-618. CrossRef
    31. Martin E, O'Sullivan B, Low P, Thomas R: Antigen-specific suppression of a primed immune response by dendritic cells mediated by regulatory T cells secreting interleukin-10. / Immunity 2003, 18:155-67. CrossRef
    32. Murugaiyan G, Martin S, Saha B: Levels of CD40 expression on dendritic cells dictate tumour growth or regression. / Clin Exp Immunol 2007, 149:194-02. CrossRef
    33. Smith DW, Nagler-Anderson C: Preventing intolerance: the induction of nonresponsiveness to dietary and microbial antigens in the intestinal mucosa. / J Immunol 2005, 174:3851-857.
    34. Suzuki M, Zheng X, Zhang X, Ichim TE, Sun H, Kubo N, Beduhn M, Shunnar A, Garcia B, Min WP: Inhibition of allergic responses by CD40 gene silencing. / Allergy 2009, 64:387-97. CrossRef
    35. Joffre O, Nolte MA, Sporri R, Reis e Sousa C: Inflammatory signals in dendritic cell activation and the induction of adaptive immunity. / Immunol Rev 2009, 227:234-47. CrossRef
    36. Lutz MB, Schuler G: Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? / Trends Immunol 2002, 23:445-49. CrossRef
    37. Menges M, Rossner S, Voigtlander C, Schindler H, Kukutsch NA, Bogdan C, Erb K, Schuler G, Lutz MB: Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity. / J Exp Med 2002, 195:15-1. CrossRef
    38. Sporri R, Reis e Sousa C: Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function. / Nat Immunol 2005, 6:163-70. CrossRef
    39. Snijders A, Kalinski P, Hilkens CM, Kapsenberg ML: High-level IL-12 production by human dendritic cells requires two signals. / Int Immunol 1998, 10:1593-598. CrossRef
    40. Schulz O, Edwards AD, Schito M, Aliberti J, Manickasingham S, Sher A, Reis e Sousa C: CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. / Immunity 2000, 13:453-62. CrossRef
    41. Kato T, Hakamada R, Yamane H, Nariuchi H: Induction of IL-12 p40 messenger RNA expression and IL-12 production of macrophages via CD40-CD40 ligand interaction. / J Immunol 1996, 156:3932-938.
    42. Morelli AE, Zahorchak AF, Larregina AT, Colvin BL, Logar AJ, Takayama T, Falo LD, Thomson AW: Cytokine production by mouse myeloid dendritic cells in relation to differentiation and terminal maturation induced by lipopolysaccharide or CD40 ligation. / Blood 2001, 98:1512-523. CrossRef
    43. Alderson MR, Armitage RJ, Tough TW, Strockbine L, Fanslow WC, Spriggs MK: CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40. / J Exp Med 1993, 178:669-74. CrossRef
    44. Nguyen VT, Benveniste EN: Critical role of tumor necrosis factor-alpha and NF-kappa B in interferon-gamma -induced CD40 expression in microglia/macrophages. / J Biol Chem 2002, 277:13796-3803. CrossRef
    45. Wesemann DR, Dong Y, O'Keefe GM, Nguyen VT, Benveniste EN: Suppressor of cytokine signaling 1 inhibits cytokine induction of CD40 expression in macrophages. / J Immunol 2002, 169:2354-360.
    46. Hirschfeld M, Ma Y, Weis JH, Vogel SN, Weis JJ: Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2. / J Immunol 2000, 165:618-22.
    47. Re F, Strominger JL: IL-10 released by concomitant TLR2 stimulation blocks the induction of a subset of Th1 cytokines that are specifically induced by TLR4 or TLR3 in human dendritic cells. / J Immunol 2004, 173:7548-555.
    48. Ling P, Gately MK, Gubler U, Stern AS, Lin P, Hollfelder K, Su C, Pan YC, Hakimi J: Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity. / J Immunol 1995, 154:116-27.
    49. Gillessen S, Carvajal D, Ling P, Podlaski FJ, Stremlo DL, Familletti PC, Gubler U, Presky DH, Stern AS, Gately MK: Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist. / Eur J Immunol 1995, 25:200-06. CrossRef
    50. Nigg AP, Zahn S, Ruckerl D, Holscher C, Yoshimoto T, Ehrchen JM, Wolbing F, Udey MC, von Stebut E: Dendritic cell-derived IL-12p40 homodimer contributes to susceptibility in cutaneous leishmaniasis in BALB/c mice. / J Immunol 2007, 178:7251-258.
    51. Yoshimoto T, Wang CR, Yoneto T, Waki S, Sunaga S, Komagata Y, Mitsuyama M, Miyazaki J, Nariuchi H: Reduced T helper 1 responses in IL-12 p40 transgenic mice. / J Immunol 1998, 160:588-94.
    52. Frick JS, Grunebach F, Autenrieth IB: Immunomodulation by semi-mature dendritic cells: A novel role of Toll-like receptors and interleukin-6. / Int J Med Microbiol 2010,300(1):19-4. CrossRef
    53. Diehl S, Chow CW, Weiss L, Palmetshofer A, Twardzik T, Rounds L, Serfling E, Davis RJ, Anguita J, Rincon M: Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation. / J Exp Med 2002, 196:39-9. CrossRef
    54. Murphy KM, Ouyang W, Farrar JD, Yang J, Ranganath S, Asnagli H, Afkarian M, Murphy TL: Signaling and transcription in T helper development. / Annu Rev Immunol 2000, 18:451-94. CrossRef
    55. Diehl S, Rincon M: The two faces of IL-6 on Th1/Th2 differentiation. / Mol Immunol 2002, 39:531-36. CrossRef
    56. Diehl S, Anguita J, Hoffmeyer A, Zapton T, Ihle JN, Fikrig E, Rincon M: Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1. / Immunity 2000, 13:805-15. CrossRef
    57. Aicher A, Shu GL, Magaletti D, Mulvania T, Pezzutto A, Craxton A, Clark EA: Differential role for p38 mitogen-activated protein kinase in regulating CD40-induced gene expression in dendritic cells and B cells. / J Immunol 1999, 163:5786-795.
    58. Yu Q, Kovacs C, Yue FY, Ostrowski MA: The role of the p38 mitogen-activated protein kinase, extracellular signal-regulated kinase, and phosphoinositide-3-OH kinase signal transduction pathways in CD40 ligand-induced dendritic cell activation and expansion of virus-specific CD8+ T cell memory responses. / J Immunol 2004, 172:6047-056.
    59. Dillon S, Agrawal A, Van Dyke T, Landreth G, McCauley L, Koh A, Maliszewski C, Akira S, Pulendran B: A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells. / J Immunol 2004, 172:4733-743.
    60. Mathur RK, Awasthi A, Wadhone P, Ramanamurthy B, Saha B: Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses. / Nat Med 2004, 10:540-44. CrossRef
    61. Mukherjee P, Chauhan VS: Plasmodium falciparum-free merozoites and infected RBCs distinctly affect soluble CD40 ligand-mediated maturation of immature monocyte-derived dendritic cells. / J Leukoc Biol 2008, 84:244-54. CrossRef
    62. Goodridge HS, Harnett W, Liew FY, Harnett MM: Differential regulation of interleukin-12 p40 and p35 induction via Erk mitogen-activated protein kinase-dependent and -independent mechanisms and the implications for bioactive IL-12 and IL-23 responses. / Immunology 2003, 109:415-25. CrossRef
    63. Lu HT, Yang DD, Wysk M, Gatti E, Mellman I, Davis RJ, Flavell RA: Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. / EMBO J 1999, 18:1845-857. CrossRef
    64. Clark AR, Dean JL, Saklatvala J: Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38. / FEBS Lett 2003, 546:37-4. CrossRef
    65. Vanden Berghe W, Plaisance S, Boone E, De Bosscher K, Schmitz ML, Fiers W, Haegeman G: p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor. / J Biol Chem 1998, 273:3285-290. CrossRef
    66. Vermeulen L, De Wilde G, Van Damme P, Vanden Berghe W, Haegeman G: Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). / EMBO J 2003, 22:1313-324. CrossRef
    67. Yanagawa Y, Onoe K: Distinct regulation of CD40-mediated interleukin-6 and interleukin-12 productions via mitogen-activated protein kinase and nuclear factor kappaB-inducing kinase in mature dendritic cells. / Immunology 2006, 117:526-35. CrossRef
    68. Kikuchi K, Yanagawa Y, Iwabuchi K, Onoe K: Differential role of mitogen-activated protein kinases in CD40-mediated IL-12 production by immature and mature dendritic cells. / Immunol Lett 2003, 89:149-54. CrossRef
  • 作者单位：Anna-Maria Gerlach (1)
    Alexander Steimle (1)
    Lea Krampen (1)
    Alexandra Wittmann (1)
    Kerstin Gronbach (1)
    Julia Geisel (1)
    Ingo B Autenrieth (1)
    Julia-Stefanie Frick (1)

    1. Institute for Medical Microbiology and Hygiene, University Hospital of Tübingen, 72076 Elfriede-Aulhorn-Str. 6, Tübingen, D-72076, Germany
  • ISSN：1471-2172
文摘
Background DC are among the first antigen presenting cells encountering bacteria at mucosal surfaces, and play an important role in maintenance of regular homeostasis in the intestine. Upon stimulation DC undergo activation and maturation and as initiators of T cell responses they have the capacity to stimulate na?ve T cells. However, stimulation of na?ve murine DC with B. vulgatus or LPS at low concentration drives DC to a semimature (sm) state with low surface expression of activation-markers and a reduced capacity to activate T-cells. Additionally, semimature DC are nonresponsive to subsequent TLR stimulation in terms of maturation, TNF-α but not IL-6 production. Ligation of CD40 is an important mechanism in enhancing DC maturation, function and capacity to activate T-cells. We investigated whether the DC semimaturation can be overcome by CD40 ligation. Results Upon CD40 ligation smDC secreted IL-12p40 but not the bioactive heterodimer IL-12p70. Additionally, CD40 ligation of smDC resulted in an increased production of IL-6 but not in an increased expression of CD40. Analysis of the phosphorylation pattern of MAP kinases showed that in smDC the p38 phosphorylation induced by CD40 ligation is inhibited. In contrast, phosphorylation of ERK upon CD40 ligation was independent of the DC maturation state. Conclusion Our data show that the semimature differentiation state of DC can not be overcome by CD40 ligation. We suggest that the inability of CD40 ligation in overcoming DC semimaturation might contribute to the tolerogenic phenotype of semimature DC and at least partially account for maintenance of intestinal immune homeostasis.

© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号

地址：北京市海淀区学院路29号 邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700