MiR-218-targeting-Bmi-1 mediates the suppressive effect of 1,6,7-trihydroxyxanthone on liver cancer cells

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• 作者：Wei-Ming Fu (1) (2)
  Li-Peng Tang (3)
  Xiao Zhu (4)
  Ying-Fei Lu (1) (2) (6)
  Yan-Ling Zhang (5)
  Wayne Yuk-Wai LEE (6)
  Hua Wang (7)
  Yang Yu (8)
  Wei-Cheng Liang (1)
  Chun-Hay Ko (9)
  Hong-Xi Xu (10)
  Hsiang-Fu Kung (1)
  Jin-Fang Zhang (1) (11) (6)
  
• 关键词：miR ; 218 ; Liver cancer ; Bmi ; 1 ; Apoptosis ; 1 ; 6 ; 7 ; Trihydroxyxanthone
• 刊名：Apoptosis
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：20
• 期：1
• 页码：75-82
• 全文大小：1,256 KB
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• 作者单位：Wei-Ming Fu (1) (2)
  Li-Peng Tang (3)
  Xiao Zhu (4)
  Ying-Fei Lu (1) (2) (6)
  Yan-Ling Zhang (5)
  Wayne Yuk-Wai LEE (6)
  Hua Wang (7)
  Yang Yu (8)
  Wei-Cheng Liang (1)
  Chun-Hay Ko (9)
  Hong-Xi Xu (10)
  Hsiang-Fu Kung (1)
  Jin-Fang Zhang (1) (11) (6)
  
  1. School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, People鈥檚 Republic of China
  2. Institute Guangzhou of Advanced Technology, Chinese Academy of Sciences, Guanzhou, 511458, People鈥檚 Republic of China
  3. Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, People鈥檚 Republic of China
  4. Guangdong Province Key Laboratory of Medical Molecular Diagnosis, Guangdong Medical College, Dong Guan, 523808, People鈥檚 Republic of China
  6. Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, People鈥檚 Republic of China
  5. School of Medical Technology and Nursing, Shenzhen Polytechnic, Shenzhen, 518055, Guangdong, People鈥檚 Republic of China
  7. Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, People鈥檚 Republic of China
  8. Shandong Product Quality Inspection Research Institute, Jinan, People鈥檚 Republic of China
  9. Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People鈥檚 Republic of China
  10. Shanghai University of Traditional Chinese Medicine, Shanghai, People鈥檚 Republic of China
  11. Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, People鈥檚 Republic of China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Cancer Research
  Cell Biology
  Biochemistry
  Virology
  
• 出版者：Springer Netherlands
• ISSN：1573-675X

文摘

Traditional Chinese medicine is recently emerged as anti-cancer therapy or adjuvant with reduced side-effects and improved quality of life. In the present study, an active ingredient, 1,6,7-trihydroxyxanthone (THA), derived from Goodyera oblongifolia was found to strongly suppress cell growth and induce apoptosis in liver cancer cells. MicroRNAs are a group of small non-coding RNAs that regulate gene expression at post-transcriptional levels. Our results demonstrated that miR-218 was up-regulated and oncogene Bmi-1 was down-regulated by THA treatment. Further investigation showed that THA-induced-miR-218 up-regulation could lead to activation of tumor suppressor P16Ink4a and P14ARF, the main down-stream targets of Bmi-1. In conclusion, THA might be a potential anti-cancer drug candidate, at least in part, through the activation of miR-218 and suppression of Bmi-1 expression.