Multiple Imputation based Clustering Validation (MIV) for Big Longitudinal Trial Data with Missing Values in eHealth

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• 作者：Zhaoyang Zhang ; Hua Fang ; Honggang Wang
• 刊名：Journal of Medical Systems
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：40
• 期：6
• 全文大小：1,082 KB
• 刊物类别：Mathematics and Statistics
• 刊物主题：Statistics
  Statistics for Life Sciences, Medicine and Health Sciences
  Health Informatics and Administration
  
• 出版者：Springer Netherlands
• ISSN：1573-689X
• 卷排序：40

文摘

Web-delivered trials are an important component in eHealth services. These trials, mostly behavior-based, generate big heterogeneous data that are longitudinal, high dimensional with missing values. Unsupervised learning methods have been widely applied in this area, however, validating the optimal number of clusters has been challenging. Built upon our multiple imputation (MI) based fuzzy clustering, MIfuzzy, we proposed a new multiple imputation based validation (MIV) framework and corresponding MIV algorithms for clustering big longitudinal eHealth data with missing values, more generally for fuzzy-logic based clustering methods. Specifically, we detect the optimal number of clusters by auto-searching and -synthesizing a suite of MI-based validation methods and indices, including conventional (bootstrap or cross-validation based) and emerging (modularity-based) validation indices for general clustering methods as well as the specific one (Xie and Beni) for fuzzy clustering. The MIV performance was demonstrated on a big longitudinal dataset from a real web-delivered trial and using simulation. The results indicate MI-based Xie and Beni index for fuzzy-clustering are more appropriate for detecting the optimal number of clusters for such complex data. The MIV concept and algorithms could be easily adapted to different types of clustering that could process big incomplete longitudinal trial data in eHealth services.KeywordsBig dataValidationMultiple imputationFuzzy clusteringMissing dataLongitudinal trial