Respiratory effect of beta-blockers in people with asthma and cardiovascular disease: population-based nested case control study

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• 作者：Daniel R. Morales ; Brian J. Lipworth ; Peter T. Donnan ; Cathy Jackson…
• 关键词：Asthma ; Cardiovascular disease ; Beta ; blocker ; Drug safety ; Pharmacovigilance
• 刊名：BMC Medicine
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：15
• 期：1
• 全文大小：397KB
• 刊物主题：Medicine/Public Health, general; Biomedicine, general;
• 出版者：BioMed Central
• ISSN：1741-7015
• 卷排序：15

文摘

BackgroundCardiovascular disease (CVD) is a common comorbidity in people with asthma. However, safety concerns have caused heterogeneity in clinical guideline recommendations over the use of cardioselective beta-blockers in people with asthma and CVD, partly because risk in the general population has been poorly quantified. The aim of this study was to measure the risk of asthma exacerbations with beta-blockers prescribed to a general population with asthma and CVD.