Benzoic acid: an efficient and rapid catalyst for the synthesis of α-hydroxyl(indolyl)ethanones from indoles

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• 作者：Guanghui Lü ; Xu Cheng ; Yang Zheng ; Weijian Li…
• 刊名：Chemical Research in Chinese Universities
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：32
• 期：2
• 页码：212-218
• 全文大小：397 KB
• 刊物主题：Chemistry/Food Science, general; Analytical Chemistry; Inorganic Chemistry; Organic Chemistry; Physical Chemistry;
• 出版者：Springer Berlin Heidelberg
• ISSN：2210-3171
• 卷排序：32

文摘

An efficient method for regioselective Friedel-Crafts alkylations of indole using arylglyoxals in the presence of benzoic acid has been discovered. The reactions proceeded smoothly at room temperature under metalfree conditions and generated the corresponding products in good to excellent yields. This methodology has a broad substrate scope and opens up an interesting and attractive avenue for the synthesis of α-hydroxyl(indolyl)-ethanones.KeywordsFriedel-Crafts alkylationIndoleArylglyoxalBenzoic acid