Impairments in microvascular function and skeletal muscle oxygenation in women with gestational diabetes mellitus: links to cardiovascular disease risk factors
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- 作者：Konstantina Dipla ; Areti Triantafyllou ; Iris Grigoriadou…
- 关键词：Arterial stiffness ; Endothelial function ; Exercise ; Gestational diabetes mellitus ; Microvascular function ; Near ; infrared spectroscopy ; Pulse wave velocity ; Skeletal muscle oxygen consumption ; Vascular reactivity
- 刊名：Diabetologia
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：60
- 期：1
- 页码：192-201
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Internal Medicine; Metabolic Diseases; Human Physiology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-0428
- 卷排序：60
文摘
Aims/hypothesisGestational diabetes mellitus (GDM) is a risk factor for the development of endothelial dysfunction and cardiovascular disease. However, in vivo microvascular endothelial function in GDM has not been investigated. This study aimed to examine, using near-infrared spectroscopy (NIRS), whether: (1) there are differences in microvascular reactivity and skeletal muscle oxygen consumption (m\( \overset{\cdot }{V}{\mathrm{O}}_2 \)) at rest and during exercise between GDM and uncomplicated pregnancies; and (2) there is an association of NIRS indices with macrovascular function and cardiovascular disease risk factors.