Decreased expression of MicroRNA-200 family in human breast cancer is associated with lymph node metastasis

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• 作者：Feng Xu ; Hua He ; Wen Huang ; Yunting Lin ; Shiyu Luo…
• 关键词：MicroRNA ; 200 ; Breast cancer ; Clinicopathology ; Real ; time quantitative PCR
• 刊名：Clinical and Translational Oncology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：18
• 期：3
• 页码：283-288
• 全文大小：606 KB
• 参考文献：1.Redig AJ, McAllister SS. Breast cancer as a systemic disease: a view of metastasis. J Intern Med. 2013;274(2):113–26.PubMedCentral CrossRef PubMed
  2.Wang L, Wang J. MicroRNA-mediated breast cancer metastasis: from primary site to distant organs. Oncogene. 2012;31(20):2499–511.CrossRef PubMed
  3.Huber MA, Kraut N, Beug H. Molecular requirements for epithelial–mesenchymal transition during tumor progression. Curr Opin Cell Biol. 2005;17(5):548–58.CrossRef PubMed
  4.Shi M, Liu D, Duan H, Shen B, Guo N. Metastasis-related miRNAs, active players in breast cancer invasion, and metastasis. Cancer Metastasis Rev. 2010;29:785–99.CrossRef PubMed
  5.Bouyssou JM, Manier S, Huynh D, Issa S, Roccaro AM, Ghobrial IM. Regulation of microRNAs in cancer metastasis. Biochim Biophys Acta. 2014;45(2):255–65.
  6.Hurst DR, Edmonds MD, Welch DR. Metastamir: the field of metastasis-regulatory. microRNA is spreading. Cancer Res. 2009;69(19):7495–8.PubMedCentral CrossRef PubMed
  7.Park SM, Gaur AB, Lengyel E, Peter ME. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev. 2008;22:894–907.PubMedCentral CrossRef PubMed
  8.Korpal M, Lee ES, Hu G, Kang Y. The miR-200 family inhibits epithelial–mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem. 2008;283:14910–4.PubMedCentral CrossRef PubMed
  9.Liu YN, Yin JJ, Abou-Kheir W, Hynes PG, Casey OM, Fang L, et al. MiR-1 and miR-200 inhibit EMT via slug-dependent and tumorigenesis via slug-independent mechanisms. Oncogene. 2013;32:296–306.CrossRef PubMed
  10.Choi PS, Zakhary L, Choi WY, Caron S, Alvarez-Saavedra E, Miska EA, et al. Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron. 2008;57:41–55.PubMedCentral CrossRef PubMed
  11.Baffa R, Fassan M, Volinia S, O’Hara B, Liu CG, Palazzo JP, et al. MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets. J Pathol. 2009;219:214.CrossRef PubMed
  12.Tuomarila M, Luostari K, Soini Y, Kataja V, Kosma VM, Mannermaa A. Overexpression of microRNA-200c predicts poor outcome in patients with PR-negative breast cancer. PLoS One. 2014;9(10):e109508.PubMedCentral CrossRef PubMed
  13.Yu SJ, Hu JY, Kuang XY, Luo JM, Hou YF, Di GH, et al. MicroRNA-200a promotes anoikis resistance and metastasis by targeting YAP1 in human breast cancer. Clin Cancer Res. 2013;19(6):1389–99.CrossRef PubMed
  14.Zhang HF, Xu LY, Li EM. A family of pleiotropically acting microRNAs in cancer progression, miR-200: potential cancer therapeutictargets. Curr Pharm Des. 2014;20(11):1896–903.CrossRef PubMed
  15.Du Y, Xu Y, Ding L, Yao H, Yu H, Zhou T, et al. Down-regulation of miR-141 in gastric cancer and its involvement in cell growth. J Gastroenterol. 2009;44(6):556–61.CrossRef PubMed
  16.Paterson EL, Kazenwadel J, Bert AG, Khew-Goodall Y, Ruszkiewicz A, Goodall GJ. Down-regulation of the miRNA-200 family at the invasive front of colorectal cancers with degraded basement membrane indicates EMT is involved in cancer progression. Neoplasia. 2013;15(2):180–91.PubMedCentral CrossRef PubMed
  17.Braun J, Hoang-Vu C, Dralle H, Hüttelmaier S. Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas. Oncogene. 2010;29(29):4237–44.CrossRef PubMed
  18.Wiklund ED, Bramsen JB, Hulf T, Dyrskjøt L, Ramanathan R, Hansen TB, et al. Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer. Int J Cancer. 2011;128(6):1327–34.CrossRef PubMed
  19.Murakami Y, Yasuda T, Saigo K, Urashima T, Toyoda H, Okanoue T, et al. Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene. 2006;25:2537–45.CrossRef PubMed
  20.Jang K, Ahn H, Sim J, Han H, Abdul R, Paik SS, et al. Loss of microRNA-200a expression correlates with tumor progression in breast cancer. Transl Res. 2014;163(3):242–51.CrossRef PubMed
  21.Ye F, Tang H, Liu Q, Xie X, Wu M, Liu X, et al. MiR-200b as a prognostic factor in breast cancer targets multiple members of RAB family. J Transl Med. 2014;12:17.PubMedCentral CrossRef PubMed
  22.Berber U, Yilmaz I, Narli G, Haholu A, Kucukodaci Z, Demirel D. MiR-205 and miR-200c: predictive micro RNAs for lymph node metastasis in triple negative breast cancer. J Breast Cancer. 2014;17(2):143–8.PubMedCentral CrossRef PubMed
  23.Weidner N, Cady B, Goodson WH 3rd. Pathologic prognostic factors for patients with breast carcinoma. Which factors are important. Surg Oncol Clin N Am. 1997;6(3):415–62.PubMed
  24.Vinh-Hung V, Cserni G, Burzykowski T. Effect of the number of uninvolved nodes on survival in early breast cancer. Oncol Rep. 2003;10(2):363–8.PubMed
  25.Hilsenbeck SG, Ravdin PM, de Moor CA, Chamness GC, Osborne CK, Clark GM. Time-dependence of hazard ratios for prognostic factors in primary breast cancer. Breast Cancer Res Treat. 1998;52:227–37.CrossRef PubMed
  26.Truong PT, Vinh-Hung V, Cserni G, Woodward WA, Tai P, Vlastos G, et al. The number of positive nodes and the ratio of positive to excised nodes are significant predictors of survival in women with micrometastatic node-positive breast cancer. Eur J Cancer. 2008;44(12):1670–7.CrossRef PubMed
  
• 作者单位：Feng Xu (2)
  Hua He (1)
  Wen Huang (1)
  Yunting Lin (1)
  Shiyu Luo (1)
  Qian Du (1)
  Ranhui Duan (1)
  
  2. Department of Breast and Thyroid Surgery, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China
  1. The State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha, 410078, Hunan, China
  
• 刊物主题：Oncology;
• 出版者：Springer Milan
• ISSN：1699-3055

文摘

Objectives MicroRNA-200 family (miR-200f) has been consistently reported to be deregulated and modulate the metastatic process in multiple cancers. In the present study, we detected the expression of miR-200f in breast cancer (BC) tissue and explored its relationships with clinicopathological characteristics, especially with lymph node metastasis.