Dietary Exposure Estimates of 14 Trace Elements in Xuanwei and Fuyuan, Two High Lung Cancer Incidence Areas in China

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• 作者：Linlin Zhang (1)
  Jungang Lv (2)
  Chunyang Liao (3)
  
• 关键词：Trace elements ; Lung cancer ; Dietary intake ; ICP ; MS
• 刊名：Biological Trace Element Research
• 出版年：2012
• 出版时间：June 2012
• 年：2012
• 卷：146
• 期：3
• 页码：287-292
• 全文大小：217KB
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• 作者单位：Linlin Zhang (1)
  Jungang Lv (2)
  Chunyang Liao (3)
  
  1. National Environmental Monitoring Center, Beijing, 100012, China
  2. Procuratoral Technology and Information Research Center, Supreme People’s Procuratorate, Beijing, 100040, China
  3. Key Laboratory of Coastal Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, 264003, China
  

文摘

Xuanwei and Fuyuan, located in the Yunnan province in southwest of China, are known to have a strikingly high incidence of lung cancer. Among the many factors that have been explored, the association between lung cancer and trace elements has not received enough attention. In this study, dietary samples were collected from 60 families of the lung cancer and control groups and abundances of 14 trace elements were determined using inductively coupled–plasma mass spectroscopy. Accuracy and sensitivity of the method were demonstrated by analyzing national standard reference materials. The results showed that the dietary intake of the trace elements contributed 96.6% of total intake. Among the 14 elements tested, cadmium and titanium were found to be present at a significantly higher level in the food consumed by the cancer group than by the control group. The intake of selenium by the population living in the areas is much lower than what it should be, with the people in the cancer group experiencing even more severe selenium deficiency. In addition, in both groups, the intakes of several essential elements (iron, copper, and zinc) from food and the drinking water were found to be significantly lower than required according to the Chinese Dietary Reference Intakes. The present study of the relationship between trace element intakes of lung cancer cases and controls provides important information urgently needed for the assessment of lung cancer risk of healthy subjects. The study also gives rational dietary suggestions to local residents which is important to the early diagnosis and pretreatment of lung cancer.