Arecoline induces TNF-alpha production and Zonula Occludens-1 redistribution in mouse Sertoli TM4 cells

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• 作者：Tzer-Min Kuo (1)
  Shun-Yuan Luo (3)
  Shang-Lun Chiang (1)
  Chi-Pin Lee (4)
  Yu-Fan Liu (5)
  Jan-Gowth Chang (6)
  Ming-Hsui Tsai (7)
  Ying-Chin Ko (1) (2)
  
  1. Environment-Omics-Disease Research Centre ; China Medical University Hospital ; Taichung ; Taiwan
  3. Department of Chemistry ; National Chung Hsing University ; Taichung ; Taiwan
  4. Graduate Institute of Medicine ; College of Medicine ; Kaohsiung Medical University ; Kaohsiung ; Taiwan
  5. Department of BioMedical Sciences ; Chung Shan Medical University ; Taichung ; Taiwan
  6. Center of RNA Biology and Clinical Application ; China Medical University Hospital ; Taichung ; Taiwan
  7. Department of Otorhinolaryngology ; China Medical University Hospital ; Taichung ; Taiwan
  2. Graduate Institute of Clinical Medicine Science ; China Medical University ; Taichung ; Taiwan
  
• 关键词：Arecoline ; Testis ; Serotli cell ; TNF ; alpha ; ZO ; 1 ; Micro ; Western Array
• 刊名：Journal of Biomedical Science
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：21
• 期：1
• 全文大小：1,573 KB
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• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Biomedicine
  
• 出版者：Springer Netherlands
• ISSN：1423-0127

文摘

Background Arecoline, a major alkaloid in Areca nut has the ability to induce oxidative stress. The effect of Areca nut, arecoline on reducing sperm quality and quantity were documented previously using several animal models. Junction disruption by down-regulation of the junction-adhesive protein via oxidative stress is an important route mediating abnormal spermatogenesis. Therefore, in this present study, we investigated the functional role of arecoline on junctional proteins. Results To analyze direct effects of arecoline on testis cells, confluent mouse testicular Sertoli cell line TM4 was exposed to arecoline. Arecoline decreased insoluble zonula occludens-1 (ZO-1) protein expression in TM4 cells, however, arecoline treatment increased TNF-alpha production in both TM4 and monocytic THP1 cells. In addition, ERK1/2 inhibitor PD98059 reversed arecoline effects on TNF-alpha and ZO-1. Conclusions Arecoline increases the production of TNF-alpha and induces protein redistribution of ZO-1. All these results explain the role of arecoline in male reproductive dysfunction, besides its cytotoxic induction.