Unfavorable inflammatory profile in adults at risk of type 2 diabetes identified by hemoglobin A1c levels according to the American Diabetes Association criteria
详细信息 查看全文
- 作者：T. V. Fiorentino ; M. L. Hribal ; M. Perticone ; F. Andreozzi…
- 关键词：Glucose tolerance ; HbA1c ; subclinical inflammation ; Inflammatory score
- 刊名：Acta Diabetologica
- 出版年：2015
- 出版时间：April 2015
- 年：2015
- 卷：52
- 期：2
- 页码：349-356
- 全文大小：201 KB
- 参考文献：1. International Diabetes Federation (2011) Global Burden: prevalence and projections, 2011 and 2030. las.org/content/diabetes-and-impaired-glucose-tolerance" class="a-plus-plus">http://www.diabetesatlas.org/content/diabetes-and-impaired-glucose-tolerance
2. Tuomilehto, J, Lindstr?m, J, Eriksson, JG, Valle, TT, H?m?l?inen, H, Ilanne-Parikka, P, Kein?nen-Kiukaanniemi, S, Laakso, M, Louheranta, A, Rastas, M, Salminen, V, Uusitupa, M (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344: pp. 1343-1350 lass="external" href="http://dx.doi.org/10.1056/NEJM200105033441801" target="_blank" title="It opens in new window">CrossRef
3. Knowler, WC, Barrett-Connor, E, Fowler, SE, Hamman, RF, Lachin, JM, Walker, EA, Nathan, DM (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346: pp. 393-403 lass="external" href="http://dx.doi.org/10.1056/NEJMoa012512" target="_blank" title="It opens in new window">CrossRef
4. Chiasson, JL, Josse, RG, Gomis, R, Hanefeld, M, Karasik, A, Laakso, M (2002) Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial. Lancet 359: pp. 2072-2077 lass="external" href="http://dx.doi.org/10.1016/S0140-6736(02)08905-5" target="_blank" title="It opens in new window">CrossRef
5. DeFronzo, RA, Tripathy, D, Schwenke, DC, Banerji, M, Bray, GA, Buchanan, TA, Clement, SC, Henry, RR, Hodis, HN, Kitabchi, AE, Mack, WJ, Mudaliar, S, Ratner, RE, Williams, K, Stentz, FB, Musi, N, Reaven, PD (2011) Pioglitazone for diabetes prevention in impaired glucose tolerance. N Engl J Med 364: pp. 1104-1115 lass="external" href="http://dx.doi.org/10.1056/NEJMoa1010949" target="_blank" title="It opens in new window">CrossRef
6. Chiasson, JL, Josse, RG, Gomis, R, Hanefeld, M, Karasik, A, Laakso, M (2003) Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial. JAMA 290: pp. 486-494 lass="external" href="http://dx.doi.org/10.1001/jama.290.4.486" target="_blank" title="It opens in new window">CrossRef
7. Ratner, R, Goldberg, R, Haffner, S, Marcovina, S, Orchard, T, Fowler, S, Temprosa, M (2005) Impact of intensive lifestyle and metformin therapy on cardiovascular disease risk factors in the diabetes prevention program. Diabetes Care 28: pp. 888-894 lass="external" href="http://dx.doi.org/10.2337/diacare.28.4.888" target="_blank" title="It opens in new window">CrossRef
8. Nathan, DM, Davidson, MB, DeFronzo, RA, Heine, RJ, Henry, RR, Pratley, R, Zinman, B (2007) Impaired fasting glucose and impaired glucose tolerance: implications for care. Diabetes Care 30: pp. 753-759 lass="external" href="http://dx.doi.org/10.2337/dc07-9920" target="_blank" title="It opens in new window">CrossRef
Standards of medical care in diabetes-2014. Diabetes Care 37: pp. S14-S81 lass="external" href="http://dx.doi.org/10.2337/dc14-S014" target="_blank" title="It opens in new window">CrossRef
9. Selvin, E, Steffes, MW, Zhu, H, Matsushita, K, Wagenknecht, L, Pankow, J, Coresh, J, Brancati, FL (2010) Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults. N Engl J Med 362: pp. 800-811 lass="external" href="http://dx.doi.org/10.1056/NEJMoa0908359" target="_blank" title="It opens in new window">CrossRef
10. Mann, DM, Carson, AP, Shimbo, D, Fonseca, V, Fox, CS, Muntner, P (2010) Impact of HbA1c screening criterion on the diagnosis of pre-diabetes among US adults. Diabetes Care 33: pp. 2190-2195 lass="external" href="http://dx.doi.org/10.2337/dc10-0752" target="_blank" title="It opens in new window">CrossRef
11. Mohan, V, Vijayachandrika, V, Gokulakrishnan, K, Anjana, RM, Ganesan, A, Weber, MB, Narayan, KM (2010) A1C cut points to define various glucose intolerance groups in Asian Indians. Diabetes Care 33: pp. 515-519 lass="external" href="http://dx.doi.org/10.2337/dc09-1694" target="_blank" title="It opens in new window">CrossRef
12. Olson, DE, Rhee, MK, Herrick, K, Ziemer, DC, Twombly, JG, Phillips, LS (2010) Screening for diabetes and pre-diabetes with proposed A1C-based diagnostic criteria. Diabetes Care 33: pp. 2184-2189 lass="external" href="http://dx.doi.org/10.2337/dc10-0433" target="_blank" title="It opens in new window">CrossRef
13. James, C, Bullard, KM, Rolka, DB, Geiss, LS, Williams, DE, Cowie, CC, Albright, A, Gregg, EW (2011) Implications of alternative definitions of prediabetes for prevalence in U.S. adults. Diabetes Care 34: pp. 387-391 lass="external" href="http://dx.doi.org/10.2337/dc10-1314" target="_blank" title="It opens in new window">CrossRef
14. Lorenzo, C, Wagenknecht, LE, Hanley, AJ, Rewers, MJ, Karter, AJ, Haffner, SM (2010) A1C between 5.7 and 6.4% as a mark - 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Internal Medicine
Diabetes
Metabolic Diseases - 出版者：Springer Milan
- ISSN：1432-5233
文摘
Aims We aimed to evaluate the inflammatory profile of individuals with prediabetes defined by HbA1c levels, according to the new American Diabetes Association criteria, and to determine the ability of HbA1c to identify individuals with subclinical inflammation independently of the contribution of other metabolic parameters such as fasting, 1- or 2-h post-load glucose (PG) levels. Methods High sensitivity C-reactive protein (hsCRP), erythrocyte sedimentation rate (ESR), fibrinogen, white blood cells (WBC) count and complement C3 (C3) were assessed, and oral glucose tolerance test (OGTT) was performed in 711 adults. Results Subjects were stratified into three groups according to their HbA1c levels. Poor agreement existed between HbA1c and 2-h PG criteria for identification of individuals with prediabetes (κ coefficient?=?0.300). As compared with subjects having HbA1c HbA1c 5.7-.4?%, [39-6 mmol/mol]) exhibited a significant increase of the concentration of five inflammatory markers (hsCRP, ESR, fibrinogen, WBC count, C3) as well as of a cluster of inflammatory markers, as measured by an inflammatory score after adjusting for sex, age, smoking, fasting, 1- and 2-h PG levels. In multiple regression models including sex, age, body mass index, smoking habit, fasting, 1- and 2-h PG levels, and HOMA index, HbA1c levels were significant independent contributors to each of the five inflammatory markers examined. Conclusions These data suggest that HbA1c is a reliable marker of glucose homeostasis, and may identify individuals at increased risk of diabetes with unfavorable inflammatory profile independently from fasting and 2-h PG levels.