3-UTR OLR1/LOX-1 gene polymorphism and endothelial dysfunction: molecular and vascular data in never-treated hypertensive patients
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- 作者：Angela Sciacqua (1)
Ivan Presta (1)
Maria Perticone (1)
Eliezer J. Tassone (1)
Francesco Andreozzi (1)
Maria Chiara Quitadamo (2)
Federica Carla Sangiuolo (2)
Giorgio Sesti (1)
Francesco Perticone (1) - 关键词：Endothelium ; Genetics ; Hypertension ; Atherosclerosis ; OLR1/LOX ; 1
- 刊名：Internal and Emergency Medicine
- 出版年：2014
- 出版时间：April 2014
- 年：2014
- 卷：9
- 期：3
- 页码：273-281
- 全文大小：226 KB
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Ivan Presta (1)
Maria Perticone (1)
Eliezer J. Tassone (1)
Francesco Andreozzi (1)
Maria Chiara Quitadamo (2)
Federica Carla Sangiuolo (2)
Giorgio Sesti (1)
Francesco Perticone (1)
1. Department of Medical and Surgical Sciences, University Magna Gr?cia of Catanzaro, V.le Europa, 88100, Catanzaro, Italy
2. Dipartimento di Biomedicina e Prevenzione, Sezione di Genetica, Università degli Studi di Roma Tor Vergata, Rome, Italy - ISSN：1970-9366
文摘
Endothelial dysfunction represents an independent predictor for clinical events. Genetic background may promote deleterious alterations of endothelial physiology. The aim of the study was to investigate the relationship between the rs1050283 polymorphism in the 3-UTR of OLR1/LOX-1 gene and endothelial dysfunction in 178 never-treated hypertensive patients and 36 healthy subjects. The rs1050283 C/T single nucleotide polymorphism was detected, by TaqMan allelic discrimination assay. The influence of polymorphism on gene transcription rate was tested in 12 heterozygous hypertensive patients, by using an allelic imbalance assay. Forearm blood flow (FBF) was measured during intra-arterial infusion of acetylcholine (ACh), and sodium nitroprusside at increasing doses. Analysis of endothelium-dependent and endothelium-independent vasodilatation was tested according to rs1050283 polymorphism. In hypertensive patients, ACh-stimulated FBF is significantly reduced in T allele carriers (P?<?0.0001), even when the allelic imbalance assay indicates an overexpression of C allele. In healthy subjects, there is no significant difference for ACh-dependent vasodilatation among genotypic groups (P?=?0.660). In essential hypertensive patients, the T allele of OLR1/LOX-1 gene is strongly associated with an impaired endothelium-dependent vasodilatation, a powerful predictor of cardiovascular events.