High expression of periostin is dramatically associated with metastatic potential and poor prognosis of patients with osteosarcoma

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• 作者：Fei Hu (19)
  Wei Wang (20)
  Hang-Cheng Zhou (21)
  Xi-Fu Shang (19)
  
  19. Department of Orthopedics ; Anhui Provincial Hospital ; Anhui Medical University ; 17# Lujiang Road ; Hefei ; 230001 ; People鈥檚 Republic of China
  20. Department of Medical Oncology ; Anhui Provincial Hospital ; Anhui Medical University ; 17# Lujiang Road ; Hefei ; 230001 ; People鈥檚 Republic of China
  21. Department of Pathology ; Anhui Provincial Hospital ; Anhui Medical University ; 17# Lujiang Road ; Hefei ; 230001 ; People鈥檚 Republic of China
  
• 关键词：Periostin ; Osteosarcoma ; Prognosis ; Metastasis
• 刊名：World Journal of Surgical Oncology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：12
• 期：1
• 全文大小：1,173 KB
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• 刊物主题：Surgical Oncology;
• 出版者：BioMed Central
• ISSN：1477-7819

文摘

Background Recent studies have found that periostin (PN), as a kind of secreted glycoprotein, is closely related to the metastatic potential and prognosis of many kinds of tumors. This study aimed to examine the expression of PN in patients with osteosarcoma and explore the relationship of PN expression with clinicopathologic factors and prognosis. Methods PN was detected by histopathological and immunohistochemical methods in 62 cases of osteosarcoma and 62 of osteochondroma. Detailed pathological and clinical data were collected by reviewing medical records. Results The results showed that increased PN protein expression was prevalent in osteosarcoma and was significantly associated with pathologic subtype (P =0.000), tumor size (P =0.016) and Enneking stage (P =0.047). Additionally, expression of PN was found to be an independent prognostic factor in osteosarcoma patients. High expression of PN protein is closely correlated to the tumor progression and poor survival of osteosarcoma. Conclusions Our data suggest that PN is a promising biomarker for identifying individuals with poor prognostic potential and suggests its possible use as a prognostic marker in patients with osteosarcoma.