Curvulamine, a New Antibacterial Alkaloid Incorporating Two Undescribed Units from a Curvularia Species
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- 作者：Wen Bo Han ; Yan Hua Lu ; Ai Hua Zhang ; Gao Fei Zhang ; Ya Ning Mei ; Nan Jiang ; Xinxiang Lei ; Yong Chun Song ; Seik Weng Ng ; Ren Xiang Tan
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：October 17, 2014
- 年：2014
- 卷：16
- 期：20
- 页码：5366-5369
- 全文大小：322K
- ISSN：1523-7052
文摘
The white croaker (Argyrosomus argentatus) derived Curvularia sp. IFB-Z10 produces curvulamine as a skeletally unprecedented alkaloid incorporating two undescribed extender units. Curvulamine is more selectively antibacterial than tinidazole and biosynthetically unique in the new extenders formed through a decarboxylative condensation between an oligoketide motif and alanine.