Total Syntheses of (R)-Strongylodiols C and D
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- 作者：Feipeng Liu ; Jiangchun Zhong ; Shuoning Li ; Minyan Li ; Lin Wu ; Qian Wang ; Jianyou Mao ; Shikuo Liu ; Bing Zheng ; Min Wang ; Qinghua Bian
- 刊名：Journal of Natural Products
- 出版年：2016
- 出版时间：January 22, 2016
- 年：2016
- 卷：79
- 期：1
- 页码：244-247
- 全文大小：313K
- ISSN：1520-6025
文摘
The first total syntheses of two marine natural products, (R)-strongylodiols C and D, with 99% ee were achieved. The key steps of the strategy include the zipper reaction of an alkyne, the asymmetric alkynylation of an unsaturated aliphatic aldehyde catalyzed with Trost’s ProPhenol ligand, and the Cadiot–Chodkiewicz cross-coupling reaction of a chiral propargylic alcohol with a bromoalkyne.