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Optimization of Novel Acyl Pyrrolidine Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase Leading to a Development Candidate
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文摘
Optimization of a pyrrolidine-based template using structure-based design and physicochemical considerations has provided adevelopment candidate 20b (3082) with submicromolar potency in theHCV replicon and good pharmacokinetic properties.

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