Enantioselective Intramolecular Formal [2 + 4] Annulation of Acrylates and 伪,尾-Unsaturated Imines Catalyzed by Amino Acid Derived Phosphines
详细信息 查看全文
- 作者：Zhichao Jin ; Ruojie Yang ; Yu Du ; Bhoopendra Tiwari ; Rakesh Ganguly ; Yonggui Robin Chi
- 刊名：Organic Letters
- 出版年：2012
- 出版时间：June 15, 2012
- 年：2012
- 卷：14
- 期：12
- 页码：3226-3229
- 全文大小：315K
- 年卷期：v.14,no.12(June 15, 2012)
- ISSN：1523-7052
文摘
The first chiral phosphine-catalyzed activation of acrylates for intramolecular formal [2 + 4] reactions with unsaturated imines is described. The catalytic reactions afford N-heterocycles with exceptionally high diastereo- and enantioselectivities. The [2 + 4] products are amenable for further transformations to useful molecules such as chiral piperidines and multicyclic structures.