Asymmetric Synthesis of Sulfinamides Using (鈭?-Quinine as Chiral Auxiliary

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• 作者：Yongda Zhang ; Sampada Chitale ; Navneet Goyal ; Guisheng Li ; Zhengxu S. Han ; Sherry Shen ; Shengli Ma ; Nelu Grinberg ; Heewon Lee ; Bruce Z. Lu ; Chris H. Senanayake
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：January 6, 2012
• 年：2012
• 卷：77
• 期：1
• 页码：690-695
• 全文大小：331K
• 年卷期：v.77,no.1(January 6, 2012)
• ISSN：1520-6904

文摘

A process has been designed and demonstrated for the asymmetric synthesis of sulfinamides using quinine as auxiliary. A variety of chiral sulfinamides including N-alkyl sulfinamides with diverse structure were prepared in good yields and excellent enantioselectivity starting from easily available and inexpensive reagents. The auxiliary quinine could be recovered and recycled.