Antibacterial Anthraquinone Derivatives from a Sea Anemone-Derived Fungus Nigrospora sp.
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- 作者：Kai-Lin Yang ; Mei-Yan Wei ; Chang-Lun Shao ; Xiu-Mei Fu ; Zhi-Yong Guo ; Ru-Fang Xu ; Cai-Juan Zheng ; Zhi-Gang She ; Yong-Cheng Lin ; Chang-Yun Wang
- 刊名：Journal of Natural Products
- 出版年：2012
- 出版时间：May 25, 2012
- 年：2012
- 卷：75
- 期：5
- 页码：935-941
- 全文大小：287K
- 年卷期：v.75,no.5(May 25, 2012)
- ISSN：1520-6025
文摘
Chemical investigation of a marine-derived fungus Nigrospora sp., isolated from an unidentified sea anemone, yielded two new hydroanthraquinone analogues, 4a-epi-9伪-methoxydihydrodeoxybostrycin (1) and 10-deoxybostrycin (2), together with seven known anthraquinone derivatives (3鈥?b>9). The structures of the two new compounds were established through extensive NMR spectroscopy as well as a single-crystal X-ray diffraction analysis using Cu K伪 radiation. The antibacterial activities of compounds 1鈥?/i>9 and 10 acetyl derivatives (6a, 7a, 8a鈥?b>8g, 9a) were evaluated in vitro. Compound 6a, the acetylated derivative of 6, exhibited promising activity against Bacillus cereus with an MIC value of 48.8 nM, which was stronger than that of the positive control ciprofloxacin (MIC = 1250 nM). Analysis of the antibacterial screening data for the metabolites and their acetyl derivatives revealed the key structural features required for this activity.