Palladium-Catalyzed Highly Stereoselective Synthesis of N-Aryl-3-arylmethylisoxazolidines via Tandem Arylation of O-Homoallylhydroxylamines

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• 作者：Jinsong Peng ; Wenqing Lin ; Shixue Yuan ; Yuanwei Chen
• 刊名：Journal of Organic Chemistry
• 出版年：2007
• 出版时间：April 13, 2007
• 年：2007
• 卷：72
• 期：8
• 页码：3145 - 3148
• 全文大小：79K
• 年卷期：v.72,no.8(April 13, 2007)
• ISSN：1520-6904

文摘

The palladium-catalyzed tandem arylation of O-homoallylhydroxylamines with 2 equiv of aryl bromides was examined.With Pd₂(dba)₃ (1 mol %) as the catalyst, Xantphos(2 mol %) as the ligand, and NaOt-Bu as the base, thereactions of O-homoallylhydroxylamines with aryl bromidesvia sequential N-arylation/cyclization/C-arylation in tolueneafforded the corresponding N-aryl-3-arylmethylisoxazolidinesin good yields with excellent diastereoselectivity.