Carbon Dots for Optical Imaging in Vivo

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• 作者：Sheng-Tao Yang ; Li Cao ; Pengju G. Luo ; Fushen Lu ; Xin Wang ; Haifang Wang ; Mohammed J. Meziani ; Yuanfang Liu ; Gang Qi ; Ya-Ping Sun
• 刊名：Journal of the American Chemical Society
• 出版年：2009
• 出版时间：August 19, 2009
• 年：2009
• 卷：131
• 期：32
• 页码：11308-11309
• 全文大小：179K
• 年卷期：v.131,no.32(August 19, 2009)
• ISSN：1520-5126

文摘

It was found and recently reported that small carbon nanoparticles can be surface-passivated by organic or biomolecules to become strongly fluorescent. These fluorescent carbon nanoparticles, dubbed “carbon dots”, can be successfully used for in vitro cell imaging with both one- and two-photon excitations, as already demonstrated in the literature. Here we report the first study using carbon dots for optical imaging in live mice. The results suggest that the carbon dots remain strongly fluorescent in vivo, which, coupled with their biocompatibility and nontoxic characteristics, might offer great potential for imaging and related biomedical applications.